香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部分內容而產生或因倚 賴該等內容而引致的任何損失承擔任何責任。 和鉑醫藥控股有限公司 HBM Holdings Limited （於開曼群島註冊成立的有限公司） （股份代號：02142） 授出股份獎勵 授出獎勵（「授出獎勵」）的詳情如下： 所授出獎勵行使價： 零 股份於授出日期 的市價： 每股股份13.10港元 1 授出日期： 2026年3月31日 所授出獎勵數目： 103,000股股份 承授人數目： 一名本集團非關連僱員（不包括高級管理層）（「獎勵承授 人」） 歸屬期及績效目標： (i) 獎勵的25%於2027年12月31日歸屬； (ii) 獎勵的25%於2028年12月31日歸屬；及 本公告乃根據香港聯合交易所有限公司（「聯交所」）證券上市規則（「上市規則」） 第17.06A條刊發。 和鉑醫藥控股有限公司（「本公司」，連同其附屬公司統稱為「本集團」）董事會 （「董事會」）謹此宣佈，於2026年3月31日，根據股東於2020年11月23日採納的 股份獎勵計劃（「股 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因倚賴 該等內容而引致的任何損失承擔任何責任。 和鉑醫藥控股有限公司 HBM Holdings Limited （於開曼群島註冊成立的有限公司） （股份代號：02142） 截至二零二五年十二月三十一日止年度的 年度業績公告 和鉑醫藥控股有限公司（「本公司」，連同其子公司統稱「本集團」）董事（「董事」） 會（「董事會」）欣然公佈本集團截至二零二五年十二月三十一日止年度（「報告期」） 的經審核綜合年度業績。該等年度業績已由本公司的審核委員會（「審核委員會」） 審閱。 於本公告內，「我們」指本公司，惟倘文義另有所指，則指本集團。 | 財務摘要 | | | | --- | --- | --- | | | 於十二月三十一日╱ | | | | 截至十二月三十一日止年度 | | | | 二零二五年 | 二零二四年 | | | 千美元 | 千美元 | | 收入 | 157,975 | 38,100 | | 銷售成本 | (8,731) | (4,486) | | 其他 ...

Group 1 - Harbour BioMed is a global biopharmaceutical company focused on the discovery and development of novel antibodies [1] - The company is listed on the Hong Kong Stock Exchange under the ticker 02142 [1]

摩·咨询 查数据·找摩熵 摩炳咨询 医药行业观察周报 2026.03.09-2026.03.15 摩熵·咨询 摩咨询一医药行业观察周报 查数据·找摩 目录 | 本周国内创新药/改良型新药申请临床/获批临床/申请上市/获批上市数据分析。 | | | --- | --- | | 1.1总体概况 | | | 1.2本周获批临床创新药/改良型新药信息速览(不含补充申请) | | | 1.3本周获批上市创新药信息速览 | 10 | | 、本周国内仿制药/生物类似物申报/审批数据分析。 | 10 | | 2.1总体概况， | 10 | | 2.2本周通过/视同通过一致性评价全局分析. | 11 | | 2.3本周首次过评/视同过评、过评/视同过评达7 家品种盘点 | 12 | | 三、本周国内医药大健康行业政策法规汇总 | 13 | | 3.1本周国内医药大健康行业政策法规速览 | .13 | | 3.2本周重点行业政策详细说明， | .14 | | 》国家药监局综合司关于学习宣传贯彻《中华人民共和国药品管理法实施条例》的通知 | .14 | | 四、本周全球创新药研发概览 | .14 | | 4.1本周全球TOP10创 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部分內容而產生或因倚 賴該等內容而引致的任何損失承擔任何責任。 和鉑醫藥控股有限公司 HBM Holdings Limited （於開曼群島註冊成立的有限公司） （股份代號：02142） 董事會會議召開日期 主席兼執行董事 王勁松博士 香港，2026年3月18日 於本公告日期，董事會包括執行董事王勁松博士及戎一平博士；獨立非執行董事 Robert Irwin Kamen博士、葉小平博士、Albert R. Collinson博士及陳維維女士。 和鉑醫藥控股有限公司（「本公司」，連同其附屬公司統稱「本集團」）董事會（「董 事會」）茲通告謹定於2026年3月30日（星期一）舉行董事會會議，以考慮及通過本 集團截至2025年12月31日止年度的全年業績，以及處理其他事項。 承董事會命 和鉑醫藥控股有限公司 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示，概不就因本公告全部或任何部分內容而產生或因倚 賴該等內容而引致的任何損失承擔任何責任。 本公告由和鉑醫藥控股有限公司（「本公司」，連同其附屬公司統稱「本集團」）自願 作出，以告知本公司股東及潛在投資者有關本集團的最新業務更新。 本公司董事會（「董事會」）欣然宣佈，用於治療特應性皮炎的靶向胸腺基質淋巴 細胞生成素（「TSLP」）及一個未公開靶點的長效雙特異性抗體HBM7575（亦稱 SKB575）的新藥臨床試驗（「IND」）申請已獲中國國家藥品監督管理局（「NMPA」） 批准。 關於HBM7575/SKB575 HBM7575/SKB575是一款靶向TSLP及一個未公開靶點的長效雙特異性抗體，具 有雙重作用機制。一方面，通過阻斷TSLP與其受體的相互作用，其可抑制TSLP 介導的信號通路以及Th2免疫細胞的啟動；另一方面，其針對另一未公開靶點 的結合與阻斷可產生協同效應，克服TSLP單靶點抗體的耐藥問題。HBM7575/ SKB575經過工程化設計，具有延長的半衰期以及良好的可開發性，可實現 ...

股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2026年2月28日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 和鉑醫藥控股有限公司 呈交日期: 2026年3月5日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 不適用 | | | 於香港聯交所上市 (註1) | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 02142 | 說明 | | | | | | | | | 法定/註冊股份數目 | | 面值 | | 法定/註冊股本 | | | 上月底結存 | | 20,000,000,000 | USD | | 0.000025 USD | | 500,000 | | 增加 / 減少 (-) | | | 0 | | USD | | 0 | | 本月底結存 | | 20,000,000,000 | USD | | 0.000025 USD | | 500,000 | 本月底法定/註冊股本總額： USD 500,000 FF301 II. 已發 ...

Core Insights - The domestic innovative pharmaceutical industry is experiencing a surge in overseas business development (BD) collaborations, with companies like Xianweida, Frontier Biotech, and HAPO Pharmaceuticals announcing significant overseas licensing agreements, indicating a shift from single product licensing to technology transfer and global collaboration [1][4] Group 1: Recent Collaborations - Xianweida and Pfizer China have entered a commercialization strategic cooperation agreement for the GLP-1 receptor agonist Enogratide, with potential payments totaling up to $495 million [2] - Frontier Biotech has signed an exclusive licensing agreement with GlaxoSmithKline (GSK) for two small RNA products, receiving an upfront payment of $40 million and potential milestone payments totaling up to $950 million [2] - HAPO Pharmaceuticals has partnered with Solstice Oncology for the exclusive development and commercialization rights of HBM4003 outside Greater China, with an upfront payment of over $105 million and potential milestone payments of up to $1.1 billion [3] Group 2: Market Trends and Growth - The overseas BD transactions for Chinese innovative drugs are projected to grow significantly, with total transaction amounts increasing from $2.562 billion in 2017 to $140.274 billion by 2025, indicating a robust growth trajectory [5] - In January 2026, several companies, including Rongchang Biotech and Shiyao Group, have already established overseas licensing agreements, showcasing the ongoing momentum in international collaborations [4] Group 3: Financial Performance and Projections - Companies like Frontier Biotech and HAPO Pharmaceuticals are expected to see improved cash flow and financial structures due to their recent collaborations, which will support core pipeline development and technology platform upgrades [5] - HAPO Pharmaceuticals anticipates a net profit between $88 million and $95 million for 2025, driven by recurring revenue from international collaborations [6] - Three Life Health reported a revenue of 4.199 billion yuan for 2025, a 251.81% increase year-on-year, largely attributed to its collaboration with Pfizer [7] Group 4: Future Trends and Strategic Focus - The internationalization of Chinese innovative drugs is driven by both demand from multinational pharmaceutical companies facing patent cliffs and the recognition of the quality of Chinese drug research and development [8] - The BD landscape in 2026 is expected to focus on unmet clinical needs, technological differentiation, and global value, particularly in oncology and metabolic disease sectors [8] - Analysts suggest that the BD transactions will evolve towards technology output combined with product licensing, platform collaborations, and global innovation, emphasizing the importance of evaluating companies' platform capabilities and clinical milestone achievements [8]

Group 1: Company Performance - BeiGene reported a total revenue of 38.205 billion yuan for 2025, a 40.4% increase from 27.214 billion yuan in the previous year, with a net profit of 1.422 billion yuan compared to a loss of 4.978 billion yuan in the prior year [1] - United Imaging achieved a total revenue of 13.821 billion yuan in 2025, reflecting a year-on-year growth of 34.18%, with a net profit of 1.888 billion yuan, up 49.6% [2] - Innovent Biologics expects a profit increase of 80%-94% to between 1.3 billion and 1.4 billion yuan for 2025, with total revenue projected at approximately 7.7-7.8 billion yuan, a growth of 16.0%-17.6% [3] - Zai Lab reported a total revenue of $460 million for 2025, a 15% increase, with significant growth in product sales driven by the performance of its drugs [4] Group 2: Product and Market Developments - BeiGene's global sales of its product, Baiyueze®, reached 28.067 billion yuan, marking a 48.8% year-on-year increase, establishing its leadership in the BTK inhibitor market [1] - United Imaging's growth was attributed to the continuous launch of innovative products and enhanced market recognition of high-end products [2] - Zai Lab's revenue growth was primarily due to increased sales of its products, including significant gains in the fourth quarter [4] - Innovent Biologics noted that revenue growth was driven by increased income from innovative drugs and licensing agreements [3] Group 3: Strategic Moves and Collaborations - Hengrui Medicine signed an exclusive licensing and equity cooperation agreement with Solstice Oncology, with a total transaction value exceeding $1.2 billion [6] - Aibo Medical plans to acquire a 68.31% stake in Demei Medical for 683 million yuan, aiming to expand into the sports medicine sector [7] - The target company in the acquisition has 276 patented technologies and is recognized as a leading enterprise in the domestic sports medicine field [8]

Core Viewpoint - Zhongtai Securities maintains a "Buy" rating for HBM Pharmaceuticals (02142), projecting significant revenue and profit growth from the licensing agreement and milestone payments related to HBM7020 and HBM4003 [1] Group 1: Financial Projections - The company is expected to achieve total revenue of 1.4 billion, 1.594 billion, and 1.485 billion yuan for the years 2025 to 2027, an increase from previous estimates of 1.342 billion, 974 million, and 1.026 billion yuan [1] - Projected net profit attributable to the parent company is estimated at 665 million, 768 million, and 740 million yuan for the same period, up from previous estimates of 621 million, 307 million, and 432 million yuan [1] Group 2: Licensing Agreement - On February 23, 2026, HBM Pharmaceuticals announced a licensing and equity cooperation agreement with Solstice Oncology, granting exclusive development and commercialization rights for HBM4003 outside Greater China [1] - The agreement includes upfront payments totaling over 105 million USD, comprising a 50 million USD cash upfront payment, a 5 million USD near-term payment, and equity valued at over 50 million USD [1] - HBM Pharmaceuticals may also receive up to approximately 1.1 billion USD in milestone payments based on future specific events and tiered royalties based on net sales outside Greater China [1] Group 3: Product Characteristics - HBM4003 is the world's first fully human only heavy chain antibody entering clinical stages, targeting the CTLA-4 pathway, which has regained focus in immuno-oncology [2] - The product demonstrates enhanced antibody-dependent cellular cytotoxicity (ADCC) and high specificity in eliminating Treg cells expressing high levels of CTLA-4 in the tumor microenvironment [2] - Its unique mechanism of action shows potential for improved therapeutic efficacy while significantly reducing drug toxicity [2] Group 4: Clinical Trial Results - HBM4003 has shown good safety and strong efficacy in Phase I monotherapy trials, with potential indications including melanoma, non-small cell lung cancer, hepatocellular carcinoma, and neuroendocrine tumors [3] - Recent Phase II clinical data indicated positive efficacy in MSS colorectal cancer when combined with another treatment, achieving an overall response rate of 34.8% and a median progression-free survival of 4.2 months [3] - This performance is superior to existing CTLA-4 antibodies combined with PD-1 antibodies in treating advanced colorectal cancer, which typically shows progression-free survival of 2 to 3 months [3] Group 5: Cash Flow Impact - The upfront payment of over 105 million USD will directly enhance the company's cash flow [4] - This transaction, combined with the company's previous profit forecast for 2025 (estimated at 88 million to 95 million USD), will further solidify its robust cash flow [4] - The cumulative effects of multiple business development activities are expected to enhance the company's growth prospects in the medium term [4]