Core Viewpoint - Obesity is recognized as one of the most severe global public health crises of the 21st century, with the number of overweight individuals having nearly tripled over the past fifty years, according to the World Health Organization [3] Group 1: Traditional Views and New Research - The traditional view of obesity as a simple energy imbalance has dominated prevention strategies for decades, but recent research by Professor Barbara E. Corkey indicates that the causes of obesity are far more complex [4][6] - Corkey's groundbreaking research highlights the role of metabolic disruptors, such as food additives and environmental endocrine disruptors, which may be altering the body's metabolic regulation mechanisms [4][6] Group 2: The Mystery of "Eat Less, Move More" - The long-held belief that "eat less, move more" is the key to combating obesity is being challenged, as many individuals find it difficult to lose weight despite strict dietary control and exercise [6] - Corkey's research identifies environmental "obesogens" that interfere with metabolic regulation, changing fat storage methods and appetite signaling, thus complicating weight loss efforts [6][8] Group 3: Sources of Obesogens - Obesogens are found in various aspects of modern life, including ultra-processed foods, industrial pollutants in drinking water, and chemicals in everyday products, which can enter the body through multiple pathways [8][9] - The presence of these chemicals can disrupt the body's energy regulation, leading to incorrect hunger signals and excessive fat accumulation, even in individuals maintaining a healthy diet and exercise routine [8][9] Group 4: A New Paradigm in Obesity Research - The field of obesity research is undergoing a fundamental shift, moving from a focus on individual behavior to a broader understanding of environmental health factors, as proposed by Corkey's obesogen theory [10][11] - This new paradigm emphasizes the need for a systematic research framework to identify potential obesogens, understand their molecular mechanisms, and develop practical exposure-blocking strategies [10][11] Group 5: Comprehensive Strategies for Obesity Prevention - The emergence of the obesogen theory calls for a dual approach to obesity prevention, combining personal health management with societal environmental changes [12] - A comprehensive prevention model that integrates micro-level behavior interventions with macro-level environmental governance is essential to effectively combat the obesity epidemic and improve public health [12]

肥胖已成为21世纪最严峻的全球公共卫生危机之一，其蔓延速度令人震惊。据世界卫生组织最新统计，过去半个世纪全球超重人口激增 近三倍，这一数字仍在持续攀升。 传统观点将肥胖简单归结为能量失衡——即"摄入过多而消耗不足"，这种理论主导了数十年的肥胖防治策略。然而，国际知名代谢研究 专家Ba r ba r a E. Co r ke y教授的最新研究发现，肥胖的成因远比我们想象的复杂。她的突破性研究指出，现代饮食中普遍存在的食品添 加剂、环境内分泌干扰物等因素，可能正在悄然改变人体的代谢调控机制。 这些隐藏在日常生活背后的"代谢干扰因子"，正以我们尚未完全理解的方式，重塑着人类的能量代谢平衡系统。这一理论为理解全球肥 胖流行提供了全新视角，也解释了为何单纯依靠"少吃多动"往往难以取得理想效果。 随着研究的深入，科学家们逐渐意识到，对抗肥胖需要从更宏观的环境因素和更微观的分子机制双重维度着手。这场关乎人类健康的持 久战，正在揭开其复杂性的冰山一角。 这些被称为"肥胖诱导物"的化学分子广泛存在于日常生活的各个层面： 从充满添加剂的超加工食品到被工业污染的饮用水，从城市空 气中的汽车尾气到日常使用的塑料制品， 它们通过食物链 ...