Core Viewpoint - The study published in Nature Aging indicates that inflammaging, or age-related chronic inflammation, is not universal across different human populations, suggesting that it may be a byproduct of industrialized lifestyles rather than a universal aging process [1][8]. Group 1: Research Findings - The research compared industrialized populations (from Italy and Singapore) with non-industrialized populations (Tsimane from Bolivia and Orang Asli from Malaysia) to assess the universality of the inflammaging phenomenon [1][5]. - In industrialized populations, inflammation increases with age and is associated with age-related chronic diseases such as stroke, cardiovascular diseases, and cancer [7]. - In contrast, the non-industrialized populations exhibited high baseline inflammation levels due to common infections, but this inflammation did not increase with age and was not linked to chronic diseases [6][7]. Group 2: Implications - The findings challenge the existing paradigm surrounding inflammaging and highlight the importance of considering cultural, environmental, and lifestyle factors in aging research [8]. - Further exploration of how specific environmental conditions modulate inflammaging and its health outcomes could lead to targeted strategies for preventing age-related diseases in diverse global populations [8].