撰文丨王聪 编辑丨王多鱼 排版丨水成文 咖啡 ，是世界上最受欢迎的饮料 （之一） ，80% 的成年人每天至少饮用一种含 咖啡因 的饮料。据估 计，全球每天消费 30 亿杯咖啡，对于很多人来说，一杯 咖啡 是开启一天的"续命神器"。 在过去几十年， 人们对咖啡的认知已经从可能有害转变为了可能有益。 已有多项研究表明，常喝咖啡可以 带来多种健康益处， 包括降低全因死亡率及心血管疾病死亡率，降低 2 型糖尿病、非酒精性脂肪性肝病、 癌症以及其他疾病的风险。 近日， 伦敦国王学院和挪威奥斯陆大学等机构的学者合作，在《英国医学杂志》子刊 BMJ Mental Health 上 发表了题为： Coffee intake is associated with telomere length in severe mental disorders 的研究 论文。 这项对患有严重精神疾病的人群的研究发现， 每天饮用不超过 4 杯咖啡与更长的端粒有关，相当于减缓了 生物学衰老速度五年 。而每天饮用 5 杯及以上咖啡则没有益处，甚至可能造成细胞损伤。 这项研究发现了什么？——神奇的"倒J型"曲线 什么是端粒？为什么它如此重要？ 要理 ...

Core Viewpoint - The study published in Nature Aging indicates that inflammaging, or age-related chronic inflammation, is not universal across different human populations, suggesting that it may be a byproduct of industrialized lifestyles rather than a universal aging process [1][8]. Group 1: Research Findings - The research compared industrialized populations (from Italy and Singapore) with non-industrialized populations (Tsimane from Bolivia and Orang Asli from Malaysia) to assess the universality of the inflammaging phenomenon [1][5]. - In industrialized populations, inflammation increases with age and is associated with age-related chronic diseases such as stroke, cardiovascular diseases, and cancer [7]. - In contrast, the non-industrialized populations exhibited high baseline inflammation levels due to common infections, but this inflammation did not increase with age and was not linked to chronic diseases [6][7]. Group 2: Implications - The findings challenge the existing paradigm surrounding inflammaging and highlight the importance of considering cultural, environmental, and lifestyle factors in aging research [8]. - Further exploration of how specific environmental conditions modulate inflammaging and its health outcomes could lead to targeted strategies for preventing age-related diseases in diverse global populations [8].