撰文丨王聪 编辑丨王多鱼 排版丨水成文 炎症性衰老 （ inflammaging ） ，即与年龄相关的慢性炎症增加，被认为是 衰老 的一个标志。然而，目前对于基于循环细胞因子来衡量炎症性衰老还没有达成 一致的方法。 近日 ，加拿大 舍布鲁克大学和美国哥伦比亚大学的研究人员合作，在 Nature 子刊 Nature Aging 上发表了题为 ： Nonuniversality of inflammaging across human populations 的研究论文。 该研究通过比较工业化人群 （来自 意大利和新加坡的人群 ） 和非工业化人群 （来自 玻利维亚和马来西亚的原住民 ） ，发现 炎症性衰老 （ inflammaging ） 在不同群体中并不具有普遍性， 生活方式工业化程度较低的人群可能不会经历炎症性衰老。因此， 炎症性衰老可能只是工业化生活方式的副产物，因此在全球不 同人群中存在着显著差异。 短期炎症对于治愈感染至关重要，但长期炎症暴露 （炎症性衰老） 已知会增加生物学衰老和出现年龄相关性疾病的风险。不过，之前并不确定炎症性衰老对所有 人群的影响是否一致。 在这项新研究中，研究团队评估了在意大利的 ...

Group 1 - Chronic inflammation is identified as a significant factor accelerating aging, linked to the dysfunction of calcium signaling in macrophage mitochondria [1][2][4] - The process is described as "mitochondrial calcium signaling dysfunction → chronic immune activation → inflammatory aging" [3] - Chronic inflammation negatively impacts various body systems, including the brain, muscles, and metabolic health, increasing risks for diseases like Alzheimer's and type 2 diabetes [5][6] Group 2 - Lifestyle adjustments can effectively regulate inflammation levels and promote healthier aging [6] - A multi-dimensional strategy is recommended, including dietary changes, regular exercise, adequate sleep, stress management, and maintaining a healthy weight [7][32] Group 3 - Anti-inflammatory foods include colorful fruits and vegetables, omega-3 fatty acids, whole grains, and spices like turmeric [9][10][11][12] - It is advised to avoid pro-inflammatory foods such as sugar, unhealthy fats, and processed meats [14][15][16] Group 4 - Regular exercise is emphasized as a powerful tool against inflammation, with both aerobic and strength training recommended [20][23] - Sleep quality is crucial, with a target of 7-9 hours per night to reduce inflammation markers [27][28] Group 5 - Chronic psychological stress is linked to increased inflammation, and stress management techniques like mindfulness and yoga are suggested [29][31] - Environmental factors, such as pollution and chemical exposure, should be minimized to reduce inflammation [34]