撰文丨王聪 编辑丨王多鱼 排版丨水成文 造血干细胞 （ Hematopoietic Stem Cell， HSC） 通常以静息状态存在于骨髓中，但在炎症、细胞因子刺激、神经活动或缺氧条件下可被动员至血液。 慢性炎 症 作为 衰老 的标志性特征，通过促进髓系分化偏倚和降低自我更新能力加速 HSC 衰老，然而机械刺激在调控这些过程中的作用尚不明确。 2026 年 1 月 2 日，浙江大学医学院第一附属医院 陆新江 、 浙江大学医学院附属儿童医院 方马荣 、浙江大学医学院附属邵逸夫医院 冯晔 、 浙江大学医学院附 属第四医院 杨巍 等 在 Nature 子刊 Nature Aging 上发表了题为： Shear stress governs hematopoietic stem cell fate t o promote inflammation-induced aging 的研究论文。 该研究首次发现， PIEZO1 能够感知血流中的 剪切应力 （ shear stress ） ，诱导 造血干细胞 （HSC） 增殖和髓系分化，而 PIEZO1 拮抗剂可通过抑制 HSC 活化来减轻炎症诱导的衰老。 该研究首次发现， ...

Core Viewpoint - The study published in Nature Aging indicates that inflammaging, or age-related chronic inflammation, is not universal across different human populations, suggesting that it may be a byproduct of industrialized lifestyles rather than a universal aging process [1][8]. Group 1: Research Findings - The research compared industrialized populations (from Italy and Singapore) with non-industrialized populations (Tsimane from Bolivia and Orang Asli from Malaysia) to assess the universality of the inflammaging phenomenon [1][5]. - In industrialized populations, inflammation increases with age and is associated with age-related chronic diseases such as stroke, cardiovascular diseases, and cancer [7]. - In contrast, the non-industrialized populations exhibited high baseline inflammation levels due to common infections, but this inflammation did not increase with age and was not linked to chronic diseases [6][7]. Group 2: Implications - The findings challenge the existing paradigm surrounding inflammaging and highlight the importance of considering cultural, environmental, and lifestyle factors in aging research [8]. - Further exploration of how specific environmental conditions modulate inflammaging and its health outcomes could lead to targeted strategies for preventing age-related diseases in diverse global populations [8].

Group 1 - Chronic inflammation is identified as a significant factor accelerating aging, linked to the dysfunction of calcium signaling in macrophage mitochondria [1][2][4] - The process is described as "mitochondrial calcium signaling dysfunction → chronic immune activation → inflammatory aging" [3] - Chronic inflammation negatively impacts various body systems, including the brain, muscles, and metabolic health, increasing risks for diseases like Alzheimer's and type 2 diabetes [5][6] Group 2 - Lifestyle adjustments can effectively regulate inflammation levels and promote healthier aging [6] - A multi-dimensional strategy is recommended, including dietary changes, regular exercise, adequate sleep, stress management, and maintaining a healthy weight [7][32] Group 3 - Anti-inflammatory foods include colorful fruits and vegetables, omega-3 fatty acids, whole grains, and spices like turmeric [9][10][11][12] - It is advised to avoid pro-inflammatory foods such as sugar, unhealthy fats, and processed meats [14][15][16] Group 4 - Regular exercise is emphasized as a powerful tool against inflammation, with both aerobic and strength training recommended [20][23] - Sleep quality is crucial, with a target of 7-9 hours per night to reduce inflammation markers [27][28] Group 5 - Chronic psychological stress is linked to increased inflammation, and stress management techniques like mindfulness and yoga are suggested [29][31] - Environmental factors, such as pollution and chemical exposure, should be minimized to reduce inflammation [34]