Group 1 - The Hang Seng Hong Kong Stock Connect Innovative Drug Index rose by 4.4%, with a year-to-date increase of over 100% [1] - The CSI Hong Kong Stock Connect Pharmaceutical and Health Comprehensive Index increased by 4.0%, while the CSI Innovative Drug Industry Index rose by 3.0% [1] - The CSI Biotechnology Theme Index and the CSI 300 Pharmaceutical and Health Index saw increases of 2.6% and 2.5%, respectively [1] Group 2 - The Hang Seng Innovative Drug ETF (159316) has seen continuous inflows for 10 trading days, reaching a record size of over 800 million yuan [1] - The CSI Biotechnology Theme Index, which focuses on A-share biotechnology leaders, has a rolling price-to-earnings ratio of 59.8 times and has increased by 2.6% [4] - The CSI 300 Pharmaceutical and Health Index, which covers leading companies in the pharmaceutical and health industry, has a rolling price-to-earnings ratio of 31.4 times and has increased by 2.5% [4]

Market Performance - The S&P 500 index declined approximately 2.3% this week, while the Dow Jones Industrial Average fell about 2.5% [1] - The Nasdaq index dropped around 2.4%, and the Nasdaq 100 index also saw a decline of about 2.4% [1] - The semiconductor index experienced a significant drop of 4.4%, and the banking index fell approximately 4.2% [1] - The index tracking the seven major U.S. tech stocks decreased by about 2.8%, and the "Trump Tariff Losers Index" fell by 5% [1] - Small-cap stocks declined by 3.3%, while the biotechnology index saw a slight increase of 0.4% [1] Daily Performance - On Friday, the S&P 500 index initially closed down by 0.6%, with the technology sector dropping 1.2% [1] - Other sectors such as telecommunications, consumer discretionary, and financials saw declines of up to 0.9%, while the utilities sector rose by 1.2% [1] - The Nasdaq 100 index initially closed down by 0.9%, with notable declines in stocks like Workday (down 12.4%), Copart (down 11.6%), and Ross Stores (down 9.9%) [1] - Conversely, stocks such as CrowdStrike (up 2.9%), Grail (up 3.6%), and Intuit (up 8.2%) experienced gains [1]

Group 1 - The core index, the CESHKB, closed flat with a trading volume of 0.0 billion, reflecting a recent decline of 6.54% over the past month, but an increase of 26.60% over the last three months and a year-to-date rise of 21.09% [1] - The CESHKB index is compiled by China Securities Index Co., Ltd. under the commission of China Securities Trading Service Co., Ltd., aiming to reflect the overall performance of biotechnology companies listed in Hong Kong [1] - The base date for the index is December 12, 2014, with a base point of 2000.0 [1] Group 2 - The top ten holdings of the CESHKB index include: CanSino Biologics (11.12%), Innovent Biologics (10.75%), BeiGene (10.09%), WuXi Biologics (9.6%), China National Pharmaceutical Group (9.38%), Zai Lab (5.61%), 3SBio (5.2%), WuXi AppTec (4.56%), Kelun-Biotech (4.25%), and Genscript Biotech (3.54%) [1] - The index's holdings are entirely composed of companies listed on the Hong Kong Stock Exchange, with the biotechnology sector representing 60.67%, pharmaceutical and biotechnology services at 22.64%, chemical drugs at 13.14%, and medical devices at 3.55% [2]