生物医药研发是一场九死一生的长征。 来源丨 投中网 在攀登产业珠峰的征途上，创业者是孤独的勇士，亦是需要灯塔的航船。 一种声音，一份力量。「登峰前沿·大家说」系列专题，汇聚由浦东科创集团与投中信息联合发起的"浦 东科创-海望登峰（二期）CEO特训营"创业者的真实表达。聆听他们的创业独白，见证他们的成长突 破，一同亲历新一代产业领袖的思考与蜕变。 将投中网设为"星标⭐"，第一时间收获最新推送 从CRO到创业者 许杰的职业生涯始于国内最大的CRO公司。在那里，他参与了早期平台搭建、质量体系建设和客户拓 展等全方位工作。"后来有机会参与公司新赛道的开拓工作，在这个过程中，我发现整个市场对于疾病 模型的需求非常多样。" 生物医药研发是一场九死一生的长征。据统计，一款新药从研发到上市平均需要10-15年时间，耗资数 十亿美元，而成功率不足10%。其中，临床前研究阶段的疾病模型是否精准，直接关系到药物后续研 发的成败。 以数百种疾病模型，构建新药研发的基石。从大小鼠到食蟹猴，许杰与他创立的精诚智研，已为上百家 药企提供专业服务。这家立足上海张江、布局海南的"模型工厂"，正将他的蓝图变为现实。 浦东i42J SPINNOT ...

Core Insights - A significant breakthrough in synthetic kidney development has been achieved by an international research team, creating a new type of kidney tissue called "composite" that integrates key structures of the kidney [1][2] - The research indicates that these composite kidney organoids are more mature and complex than previous models, offering new hope for disease research and organ transplantation [1][3] Research and Development - The team, which includes institutions like the University of Southern California and Tongji University in China, optimized growth conditions for mouse and human kidney composites in the lab and successfully transplanted them into live mice [1][2] - The transplanted composites matured further in a natural biological environment, developing connective tissue and vascular networks [1] Functional Capabilities - The composite organoids exhibited multiple functions similar to real kidneys, including blood filtration, protein absorption, hormone secretion, and early signs of urine generation [1] - Unlike previous kidney organoids that only reached embryonic stages, these composites achieved maturity comparable to that of newborn mouse kidneys [1] Disease Modeling Potential - The research demonstrated the potential of composites as disease models, particularly for autosomal dominant polycystic kidney disease, by developing large human-like kidney cysts in mice [2] - This advancement provides a powerful new tool for studying complex kidney diseases and lays a solid foundation for designing functional synthetic kidneys for transplantation [2] Implications for Regenerative Medicine - The study signifies a substantial step towards addressing the organ shortage crisis in regenerative medicine by creating more mature and structurally complete synthetic kidney tissues [3] - The technology could lead to personalized drug testing platforms, reducing reliance on animal experiments, and ultimately developing transplantable bioartificial kidneys, transforming treatment approaches for end-stage kidney disease patients [3]