不过，这一消息发布后，石药集团1月30日股价大跌，收跌10.2%，收盘价报9.6港元/股。旗下A股公司 新诺威收跌15.72%，收盘价为38.87元/股。 北京商报讯（记者 丁宁）1月30日，石药集团（01093.HK）发布公告称，已与阿斯利康签订战略研发合 作与授权协议，以利用石药集团专有的缓释给药技术平台及多肽药物AI发现平台，开发创新长效多肽 药物。 公告显示，本次合作潜在总金额高达185亿美元，其中石药集团将获得12亿美元预付款，还将有权获得 最高35亿美元的潜在研发里程碑付款和最高138亿美元的潜在销售里程碑付款，以及基于相关授权产品 年净销售额的最高双位数比例销售提成。 ...

根据协议，合作将利用石药集团专有的缓释给药技术平台及多肽药物AI发现平台，开发创新长效多肽 药物。石药集团的长效技术可实现多肽药物的缓释，使给药间隔达到每月一次或更长。基于以上两个平 台开发的产品为即用型，使用简便，支持患者自行给药，能有效提升长期用药人群的治疗依从性，同时 可以针对药物靶点快速设计及筛选候选分子，并可在药效、选择性与信号偏向性等维度进行系统优化。 （文章来源：新华财经） 新华财经石家庄1月30日电（记者刘桃熊）记者从石药集团了解到，该集团已与全球生物制药领导者阿 斯利康签订战略研发合作与授权协议。石药集团将获得12亿美元的预付款，并有权获得最高35亿美元的 潜在研发里程碑付款、最高138亿美元的潜在销售里程碑付款，以及基于相关产品年净销售额的最高达 双位数比例的销售提成，潜在交易总额最高达185亿美元。 ...

Core Insights - AstraZeneca has entered into a strategic research and licensing agreement with CSPC Pharmaceutical Group, involving an upfront payment of $1.2 billion and a potential total deal value exceeding $18.5 billion [1][3]. Group 1: Partnership Details - The collaboration allows AstraZeneca to utilize CSPC's proprietary sustained-release drug delivery technology and AI drug discovery platform for developing innovative long-acting peptide drugs [1]. - CSPC's long-acting technology enables sustained release of peptide drugs, allowing for administration intervals of once a month or longer, enhancing patient compliance for long-term treatment [1][3]. - The partnership includes the overseas rights for a weight management product portfolio, including a clinical-ready project SYH2082 (long-acting GLP-1R/GIPR agonist) and three preclinical projects targeting obesity and weight-related issues [3]. Group 2: Financial Aspects - CSPC will receive an upfront payment of $1.2 billion, with potential milestone payments of up to $3.5 billion for research and up to $13.8 billion for sales, along with a double-digit percentage royalty based on annual net sales of the licensed products [3]. - AstraZeneca plans to invest over 100 billion RMB (approximately $15 billion) in China by 2030 to expand its pharmaceutical production and R&D footprint [4]. Group 3: Industry Context - GLP-1 has emerged as a revolutionary target in the diabetes and weight loss sectors, with the global GLP-1 development race entering its "second half," focusing on next-generation innovative weight loss therapies [3]. - The collaboration is not the first between CSPC and AstraZeneca, as they previously established a strategic partnership in June 2025, with a potential value exceeding $5 billion, focusing on AI-driven oral small molecule drug development for chronic and immune diseases [3].