12:30午饭后，不立刻坐回去，在医院内快走8分钟；回来用弹力带做外展、深蹲，各15次×2组；再顺手 提踵几组，小腿发酸就停——练的是万一跌倒时的"刹车"。 作为医生，我也过着典型的"办公室生活"：门诊、查房和开会，一坐就是半天。于是从去年开始，我在 抽屉里放了一条弹力带，并把运动写进体锻日志。 7:40准备进办公室，电梯到12楼，最后两层走楼梯；到工位先不碰电脑，靠墙静蹲30秒×2组。默念一句 提醒：今天也得让骨头"受点力"。 盛辉 "盛医生，我也没摔过啊，怎么一查就骨质疏松？""我每天上班坐着，回家也累得不想动。可体检说肌 肉少、脂肪多，这到底算病吗？" 这类问题，我在上海市第十人民医院骨质疏松与肌少症诊治中心的门诊几乎每天都会听到。很多患者以 为骨质疏松、肌少症是"退休后的事"，等到腰酸背痛、身高变矮、爬楼发怵甚至探出身子晾个衣服就骨 折，才发现自己早已错过了"性价比"最佳的干预窗口。 门诊的时候我常跟患者打比方：骨头和肌肉像一张存折。年轻时存得多，老了才经得起花；但如果在最 能存钱的年纪长期"躺平"，等退休后再想补救，当然更费劲。 我通常会把答案拆成两句话：骨量和肌肉不是凭空突然掉下去的。它们是从你开 ...

Core Viewpoint - The National Health Commission of China has released a draft for public consultation on dietary guidelines aimed at addressing three major chronic diseases: stroke, osteoporosis, and sarcopenia, with the goal of improving national nutrition and health levels [1] Group 1: Stroke Management - Poor lifestyle choices are significant factors contributing to the incidence of stroke, and nutritional management plays a crucial role in recovery [1] - The dietary guidelines are primarily intended for adult patients in the recovery phase or with sequelae of stroke, who are stable, conscious, and do not have severe swallowing difficulties [1] Group 2: Osteoporosis Guidance - Approximately 90 million people in China suffer from osteoporosis, with around 70 million being women [1] - The dietary guidelines target adult osteoporosis patients and grassroots health workers, providing nutritional guidance for prevention and improvement, but are not a substitute for medical treatment [1] Group 3: Sarcopenia Focus - Sarcopenia is an increasingly prominent public health issue in an aging society [1] - The dietary guidelines are based on modern nutritional theories and evidence, combined with traditional Chinese medicine concepts, proposing basic principles and plans for dietary management of sarcopenia [1]

Core Viewpoint - The National Health Commission has released a draft for public consultation aimed at addressing three major chronic diseases: stroke, osteoporosis, and sarcopenia, with the goal of enhancing national nutrition and health levels [1][2]. Group 1: Stroke Management - Poor lifestyle choices are significant factors contributing to stroke, and nutritional management plays a crucial role in recovery [1]. - The dietary guidelines are primarily intended for adult patients in the recovery phase or with sequelae of stroke, who are stable and can eat orally [1]. - For patients in acute phases or with severe swallowing difficulties requiring tube feeding or parenteral nutrition, individualized nutritional treatment should be guided by clinical physicians and nutritionists [1]. Group 2: Osteoporosis Guidance - Osteoporosis is recognized by the World Health Organization as the third most common disease among middle-aged and elderly individuals, following hypertension and hyperlipidemia [1]. - Approximately 90 million people in China suffer from osteoporosis, with around 70 million being women [1]. - The dietary guidelines target adult osteoporosis patients and grassroots health workers, providing nutritional guidance for prevention and improvement, but do not replace pharmacological treatment [1]. - Patients with comorbidities should refer to the guidelines for dietary planning while consulting healthcare professionals for personalized plans [1]. Group 3: Sarcopenia Focus - Sarcopenia is an increasingly prominent public health issue in aging societies, characterized by progressive loss of muscle mass and strength [2]. - The dietary guidelines for sarcopenia are based on modern nutritional science and traditional Chinese medicine, outlining basic principles and plans for dietary management [2]. - The deadline for public consultation on the draft is set for January 30, 2026 [2].

Core Viewpoint - The article emphasizes the importance of muscle health, particularly in individuals over 50, highlighting that muscle loss, or sarcopenia, is a significant health concern that can lead to decreased strength and increased risk of falls and fractures [1] Group 1: Muscle Health Awareness - Muscle is described as a "strategic reserve" for overall health, functioning as a metabolic factory and endocrine organ that regulates blood sugar and supports various bodily systems [1] - Sarcopenia is characterized not just by muscle loss in quantity but also in quality, with a notable decline starting after the age of 25 and accelerating after 50 [1] - Many individuals mistakenly believe muscle loss is only a concern for those in their 70s or 80s, often realizing the issue too late when they experience mobility problems [1] Group 2: Self-Assessment for Muscle Loss - A self-check list is provided to identify potential muscle loss, including unintentional weight loss, increased fatigue during routine tasks, and specific measurements of calf circumference [2][3] - If two or more criteria are met, it suggests the possibility of muscle loss, prompting the need for a comprehensive evaluation [3] Group 3: Diagnostic Procedures - Initial screening involves medical history inquiries and physical assessments, including calf circumference measurement and SARC-F scale evaluation [3] - Muscle strength is measured using a dynamometer, with specific thresholds indicating the need for further examination [4] - Muscle mass is assessed through DXA or bioelectrical impedance analysis, with a diagnosis of sarcopenia confirmed by low muscle strength and low muscle mass [5] Group 4: Interventions for Muscle Health - Recommended interventions include resistance training exercises that can be performed at home, which are crucial for stimulating muscle growth [5] - Nutritional strategies emphasize the importance of adequate protein intake, suggesting a daily consumption of at least 1.6g of protein per kg of body weight to support muscle repair and growth [7] - Lifestyle modifications are advised, such as avoiding smoking and excessive alcohol, minimizing sedentary behavior, and managing chronic conditions like diabetes and kidney disease to prevent further muscle loss [8]

Core Viewpoint - The study reveals the metabolic heterogeneity of sarcopenia and identifies N-methylglycine as a potential risk factor for sarcopenia, suggesting its supplementation could be a new strategy for intervention [3][6][8]. Group 1: Research Findings - The research team conducted a comprehensive plasma metabolomics and lipidomics analysis on two cohorts comprising 1,013 individuals, highlighting a significant decrease in plasma N-methylglycine levels in elderly and sarcopenic patients [6][8]. - In mouse experiments, exogenous supplementation of N-methylglycine was shown to promote anti-inflammatory macrophage polarization, effectively reducing fat accumulation during aging while maintaining skeletal muscle quality at a higher level [3][6]. - The study demonstrated that N-methylglycine activates the GCN2 signaling pathway, enhancing anti-inflammatory macrophage polarization, promoting thermogenesis in adipose tissue, and facilitating muscle regeneration [6][8]. Group 2: Clinical Implications - The research provides scientific evidence for the potential clinical translation of N-methylglycine supplementation as a strategy to prevent sarcopenia in the elderly [3][8]. - The findings suggest that N-methylglycine supplementation can significantly increase fat thermogenesis, reduce white fat, and enhance lean body mass, emphasizing its role in muscle damage repair [8].

Core Viewpoint - The issue of muscle atrophy, previously associated mainly with the elderly, is increasingly affecting younger populations, particularly young women, due to lifestyle choices and societal beauty standards [1][10][12]. Summary by Sections Muscle Atrophy Trends - Muscle atrophy, or sarcopenia, is a progressive loss of skeletal muscle quality and strength, traditionally seen in older adults, but is now emerging in younger women, starting as early as age 35 [10][22]. - The World Health Organization (WHO) reports that approximately one-third of adults globally, around 1.8 billion, are insufficiently active, with a higher proportion of women [1][7]. Factors Contributing to Muscle Loss - Many individuals begin to lose 3% to 5% of lean muscle mass every decade after age 30, with women experiencing this loss earlier and more significantly due to lower baseline muscle mass compared to men [3][10]. - Young women often engage in low-frequency exercise, such as yoga and Pilates, which may not provide sufficient stimulus for muscle growth, leading to rapid declines in muscle strength and endurance when exercise is halted [6][19]. Societal Influences and Beauty Standards - The prevailing beauty standards that favor thinness contribute to a lack of focus on muscle health among young women, who may prioritize weight loss over muscle maintenance [12][15]. - The marketing of health products often emphasizes weight loss rather than muscle gain, further perpetuating the issue [12][13]. Symptoms and Health Implications - Symptoms of muscle loss in young women may be subtle, including mild muscle weakness and increased fatigue, while older women exhibit more pronounced symptoms such as significant muscle weakness and mobility issues [25][22]. - The lack of resistance training and poor nutritional habits, such as insufficient protein intake, exacerbate the risk of developing sarcopenia [19][29]. Recommendations for Prevention - To combat muscle loss, it is recommended that young women engage in resistance training 2-3 times a week, alongside a balanced diet rich in protein and essential nutrients [28][29]. - Incorporating simple exercises and ensuring adequate nutritional intake can help maintain muscle mass and overall health [29][30].