暴露于 高海拔 （ High Altitude， HA） 环境与男性 精子生成受损 及 微生物失衡 有关；然而，两者之间 的关联及潜在机制尚不明确。 2026 年 1 月 2 日，陆军军医大学第二附属医院（新桥医院） 杨仕明 、 唐波 、 孙碧韶 等在 Cell 子刊 Cell Host & Microbe 上 发表了题为： Gut-derived succinic acid potentiates high-altitude-related spermatogenesis dysfunction 的研究论文。 撰文丨王聪 编辑丨王多鱼 排版丨水成文 具体而言，研究团队观察到 ， 在高海拔地区的人群以及处于模拟高海拔环境中的小鼠体 内，肠道细菌 共 生梭菌 （ C. symbiosum ） 的定植量有所增加。此外 ， C. symbiosum 通过产生 琥珀酸 （ succinic acid ） 导致精子质量下降。 从机制上来说， 琥珀酸 通过作用于 G 蛋白偶联受体 GPR91 来激活睾丸巨噬细胞 （TM） 中的 TRPV4/Ca 2+ 信号通路，促使它们极化为炎症性的 CD68 + CD163 - 亚群， ...

Core Viewpoint - Obesity is a global health crisis affecting over 600 million people, linked to serious complications such as type 2 diabetes, cardiovascular diseases, and cancer. Current strategies focus on direct metabolic regulation, but modulating gut microbiota to limit nutrient availability presents a promising alternative [1][2]. Group 1: Research Findings - The study published by researchers from the RIKEN Institute indicates that acetylated cellulose (AceCel) suppresses body mass gain by enabling gut commensals to consume host-accessible carbohydrates, highlighting its potential as a prebiotic [2][10]. - Gut microbiota plays a significant role in metabolizing nutrients and influencing diseases, with gut microbiota accounting for 2.5%-5% of total energy supply in humans and about 8% in mice [4]. - The research demonstrates that AceCel significantly alters gut bacterial composition and function, reducing weight gain in both wild-type and obese mice by limiting carbohydrate oxidation in the liver and promoting fatty acid oxidation [8][11]. Group 2: Mechanism of Action - AceCel enhances the fermentation of carbohydrates by gut symbionts, specifically Bacteroides thetaiotaomicron, leading to a reduction in host-accessible monosaccharides and energy intake [8][11]. - The study emphasizes the importance of acetate, a short-chain fatty acid, in modulating the interaction between gut bacteria and host metabolism, suggesting that acetate's delivery to the distal colon can improve various metabolic indicators [5][6]. Group 3: Implications for Obesity Treatment - The findings underscore the potential of AceCel as a prebiotic that can regulate carbohydrate metabolism in both bacteria and hosts, offering new hope for obesity prevention and treatment strategies [10][11].