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四招帮你切断慢性炎症
Xin Lang Cai Jing· 2025-09-01 06:14
Group 1 - Chronic inflammation is primarily caused by an imbalance between pro-inflammatory and anti-inflammatory factors in the body [2] - Factors contributing to increased pro-inflammatory factors include high-fat and high-sugar diets, stress, lack of sleep, gut microbiome imbalance, and insufficient or excessive exercise [2] Group 2 - Four methods to reduce or cut off chronic inflammation are proposed: adopting an anti-inflammatory diet, reducing stress, restoring gut microbiome with fermented foods, and engaging in moderate aerobic exercise while emphasizing muscle health [2]
Nature子刊:杨仕明团队揭示胆囊切除术加剧结直肠癌发生的新机制,并提出潜在干预方式
生物世界· 2025-08-20 08:45
Core Viewpoint - The incidence of gallbladder diseases, such as gallstones and gallbladder polyps, is increasing globally due to changes in dietary structure. Gallbladder removal surgery is the most common procedure in biliary surgery and is considered a standard treatment for patients with gallbladder diseases. However, emerging evidence indicates that post-cholecystectomy syndrome and the incidence of diseases related to metabolic syndrome have significantly increased. Notably, previous clinical studies have linked gallbladder removal surgery to an elevated risk of colorectal cancer, although the underlying mechanisms remain unclear [3][7]. Group 1 - A recent study published by a team led by Professor Yang Shiming from the Army Medical University in Nature Communications indicates that gallbladder removal surgery is associated with gut microbiota dysbiosis and impaired bile acid metabolism, which exacerbates colorectal tumorigenesis through disrupted FXR/β-catenin interactions. The FXR agonist obeticholic acid (OCA) has been shown to prevent colorectal tumors associated with gallbladder removal surgery [4][10]. - The study utilized mouse models to confirm that gallbladder removal surgery increases the occurrence of colorectal tumors. Metagenomic sequencing and targeted metabolomics revealed a reduction in Bifidobacterium breve and an increase in Ruminococcus gnavus, along with elevated levels of glycochenodeoxycholic acid (GUDCA) and tauroursodeoxycholic acid (TUDCA) in the body [8][10]. - Experiments involving fecal microbiota transplantation, single strain colonization, and bile acid supplementation demonstrated that dysbiosis related to gallbladder removal surgery promotes the production of TUDCA, thereby facilitating colorectal tumor development. Impaired bile acid metabolism inhibits FXR signaling, which ultimately exacerbates colorectal tumorigenesis [8][10].
肠道菌群失调为何会引发骨关节炎?
Ke Ji Ri Bao· 2025-05-26 01:12
Core Insights - The research reveals that metabolic factors, particularly gut health, play a significant role in the development of osteoarthritis, challenging the traditional view that it is primarily caused by local mechanical factors [1][2][3] - The study indicates a notable difference in gut microbiota composition and key metabolites between osteoarthritis patients and healthy individuals, suggesting a potential new direction for treatment [3][4] Group 1: Osteoarthritis Overview - Osteoarthritis is characterized by degeneration of joint cartilage and underlying bone, leading to pain, deformity, and functional impairment, significantly affecting patients' quality of life [2] - As of 2021, approximately 606 million people globally suffer from osteoarthritis, with around 152 million cases in China, reflecting a prevalence rate of 10.8% [2] Group 2: Research Findings - The research team conducted a large-scale study involving 4,080 community residents aged 50 and above, revealing a link between bile acid metabolism and osteoarthritis, influenced by gut microbiota [3][4] - A significant reduction in the abundance of specific gut bacteria (Bacteroides) was observed in osteoarthritis patients, correlating with abnormal bile acid metabolism [4][5] Group 3: Treatment Implications - The study suggests that supplementation with bile acids or GLP-1 analogs can significantly alleviate cartilage degeneration in osteoarthritis models, indicating a potential therapeutic pathway [5] - The findings highlight GLP-1 as a crucial mediator between gut health and joint protection, opening avenues for new treatment strategies [5] Group 4: Broader Implications of Gut Microbiota - Gut microbiota dysbiosis is linked to various diseases, including depression, diabetes, obesity, and cardiovascular diseases, emphasizing the importance of gut health in overall well-being [6][7] - The gut microbiome plays a critical role in immune regulation and systemic inflammation, with imbalances potentially leading to increased risks of autoimmune diseases and infections [7]