骨关节炎并非简单的"关节磨损"或"长骨刺"，它是一种常见的全身性关节疾病，以关节软骨的退行 性变和继发性骨质增生为特征。随着我国人口老龄化加剧，它已成为导致中老年人群关节疼痛、功能障 碍甚至致残的主要原因之一，严重影响生活质量。很多人对骨关节炎存在认知误区，要么过度焦虑认为 只能"换关节"，要么忽视早期症状延误治疗。 10月11日15:00，北京大学人民医院风湿免疫科教授李茹做客"人民好医生"科普直播间，从骨关节 炎的基础生活管理到手术干预等核心话题进行系统讲解，为您带来权威、实用的关节健康指南，助您迈 出健康每一步。 嘉宾简介： 李茹，北京大学人民医院风湿免疫科主任医师、教授、博士研究生导师。同时担任中国免疫学会自 身免疫分会常委兼秘书长、中国女医师协会风湿免疫专委会常委兼副秘书长、《Rheumatology & Autoimmunity》执行主编等学术职务。 如何收看直播： 一、下载人民好医生App，点击"名医直播"进入栏目进行收看。 更多贴心易懂的健康科普，三甲名医直播互动，请关注人民好医生APP 二、关注人民健康公众微信号（微信号：rmwjkpd），右下角点击健康互动 "下载人民好医生 App"，下载 ...

Core Insights - The article discusses the potential of circular RNA (circRNA) as a next-generation RNA therapy platform, highlighting its advantages over traditional mRNA therapies, particularly in stability, immunogenicity, and safety [2][4]. Group 1: CircRNA Advantages - CircRNA exhibits superior stability, immunogenicity, and safety compared to chemically modified mRNA and viral vector-based therapies [2]. - CircRNA can utilize internal ribosome entry site (IRES) sequences, eliminating the need for expensive 5' cap modifications and resulting in lower immunogenicity without chemical modifications [2]. Group 2: Research Findings - A study published in Nature Communications demonstrates that circRNA-based protein replacement therapy can alleviate osteoarthritis in male mice [3][4]. - Osteoarthritis (OA) is characterized by cartilage degradation and bone spur formation, with recent research indicating that the expression of Na v 1.7 in chondrocytes leads to cartilage degeneration and pain [6]. Group 3: Mechanism and Treatment Strategy - The study identifies that the downregulation of the RNA-binding protein Musashi2 (MSI2) in chondrocytes is a key factor in the pathogenesis of osteoarthritis [7]. - A local delivery strategy was developed to achieve high and sustained protein expression in chondrocytes, demonstrating that injecting ivcRNA encoding MSI2 effectively slows the progression of osteoarthritis in a mouse model [7][9].

Core Insights - The research reveals that metabolic factors, particularly gut health, play a significant role in the development of osteoarthritis, challenging the traditional view that it is primarily caused by local mechanical factors [1][2][3] - The study indicates a notable difference in gut microbiota composition and key metabolites between osteoarthritis patients and healthy individuals, suggesting a potential new direction for treatment [3][4] Group 1: Osteoarthritis Overview - Osteoarthritis is characterized by degeneration of joint cartilage and underlying bone, leading to pain, deformity, and functional impairment, significantly affecting patients' quality of life [2] - As of 2021, approximately 606 million people globally suffer from osteoarthritis, with around 152 million cases in China, reflecting a prevalence rate of 10.8% [2] Group 2: Research Findings - The research team conducted a large-scale study involving 4,080 community residents aged 50 and above, revealing a link between bile acid metabolism and osteoarthritis, influenced by gut microbiota [3][4] - A significant reduction in the abundance of specific gut bacteria (Bacteroides) was observed in osteoarthritis patients, correlating with abnormal bile acid metabolism [4][5] Group 3: Treatment Implications - The study suggests that supplementation with bile acids or GLP-1 analogs can significantly alleviate cartilage degeneration in osteoarthritis models, indicating a potential therapeutic pathway [5] - The findings highlight GLP-1 as a crucial mediator between gut health and joint protection, opening avenues for new treatment strategies [5] Group 4: Broader Implications of Gut Microbiota - Gut microbiota dysbiosis is linked to various diseases, including depression, diabetes, obesity, and cardiovascular diseases, emphasizing the importance of gut health in overall well-being [6][7] - The gut microbiome plays a critical role in immune regulation and systemic inflammation, with imbalances potentially leading to increased risks of autoimmune diseases and infections [7]