Core Insights - The study results presented at the ESMO Asia Congress 2025 indicate that the combination therapy of osemitamab with nivolumab and CAPOX shows promising clinical benefits for patients with advanced gastric or gastroesophageal junction adenocarcinoma [1][2] Group 1: Clinical Efficacy - The updated efficacy analysis from the TranStar102 trial shows a median progression-free survival (mPFS) of 16.6 months and an objective response rate (ORR) of 68% among 26 patients with CLDN18.2 expression ≥40% and known PD-L1 CPS [1] - The median duration of response (mDoR) is reported to be 18 months, indicating sustained efficacy of the treatment [1] - Higher CLDN18.2 expression correlates with better PFS outcomes regardless of PD-L1 expression levels, suggesting consistent therapeutic benefits across different patient subgroups [1] Group 2: Safety and Tolerability - The safety profile of the combination therapy remains consistent with previously reported data, indicating good tolerability and safety [1][2] - The treatment is expected to provide significant clinical benefits to patients who urgently need more effective treatment options for advanced gastric or gastroesophageal junction adenocarcinoma [2]

新分析结果进一步印证了osemitamab三联疗法所展现的令人鼓舞的临床获益。经过25.8个月的中位随访 观察，在26例CLDN18.2表达≥40%、≥2 + 且PD-L1 CPS 已知的患者中，中位无进展生存期(mPFS)达到 16.6个月，客观缓解率(ORR)为68%，中位缓解持续时间(mDoR)为18个月。值得关注的是，在PD-L1 CPS<1和≥1两个亚组中，CLDN18.2较高表达患者的PFS均优于较低表达患者，这表明 osemitamab的潜 在治疗获益不受PD-L1表达水平影响，具有一致性。 "探索性疗效分析持续表明，osemitamab联合标准治疗方案具有良好的临床获益，" 北京大学肿瘤医院消 化肿瘤内科及I期临床试验病区主任，本次研究的主要研究者沈琳教授表示，"不同PD-L1亚组患者的获 益一致性尤为值得关注，这表明该治疗方案有望为广大晚期胃或胃食管结合部腺癌患者带来具有临床意 义的获益改善。" 智通财经APP讯，创胜集团-B(06628)发布公告，公司董事会欣然宣布，osemitamab联合纳武利尤单抗与 CAPOX作为胃或胃食管结合部腺癌(TranStar102)一线治疗的I/II期临床 ...