Core Points - A 63-year-old woman experienced severe abdominal pain, nausea, and vomiting for a month, initially attributing it to stress, but was later diagnosed with gastric bezoars after a gastroscopy revealed a large stone in her stomach [3][10][14] - The patient had lost 18 kilograms over the past year due to the use of semaglutide, a GLP-1 receptor agonist, which is known for its weight loss and diabetes management effects [3][15] - The treatment for the gastric stone involved consuming 3 liters of sugar-free cola within 12 hours, which successfully dissolved the stone, highlighting an unconventional yet effective method for treating gastric bezoars [10][14] Summary by Sections Patient Background - The patient had a history of multiple health issues, including type 2 diabetes, hypertension, and chronic kidney disease, and was on 16 different medications [3][14] - Weight loss was significant, dropping from 93 kg to 75 kg, with an accelerated rate of loss in the last month [3][14] Diagnosis - The abdominal pain was attributed to either a peptic ulcer or gastric stones, with the latter confirmed through gastroscopy [3][8] - Gastric stones are formed from undigested materials and can cause symptoms like abdominal pain and nausea [8][10] Treatment - The unconventional treatment involved the patient drinking sugar-free cola, which was effective in dissolving the gastric stone [10][14] - The patient was advised to continue with pain management using opioids while discontinuing semaglutide during her hospital stay [14] Implications for Semaglutide - Semaglutide, while effective for weight loss and diabetes management, can lead to adverse effects such as nausea and delayed gastric emptying, potentially resulting in gastric stones [15][16] - The discussion around the use of semaglutide raises questions about its safety and efficacy, especially when used for weight loss without medical supervision [15][17]