可能损伤胃和肾 疼痛发作时，布洛芬是很多人救急的首选药物。在我国，布洛芬已占据抗炎镇痛药市场的近1/4。 然而，很多人也许不知道，长期或过量服用布洛芬，可能会引发胃、肾损伤。 布洛芬吃多了 布洛芬属于非甾体抗炎药，与阿司匹林、对乙酰氨基酚同属于解热镇痛药，它的作用机制是精准抑制环氧化酶（COX）活性，减少前列腺素合 成，从而削弱疼痛信号传递，实现解热、镇痛、抗炎效果。 具体来说，布洛芬可用于3种病症： 虽然布洛芬本身无成瘾性，但长期或过量服用仍可能引发两种风险： 1 胃肠道不适 包括胃痛、胃溃疡、出血等症状。布洛芬在抑制炎症相关前列腺素合成的同时，也会影响胃黏膜正常前列腺素的生成，削弱胃黏膜保护屏障。 因此，既往有胃肠道疾病史、长期大剂量用药、高龄、同时服用其他非甾体抗炎药或激素类药物，以及饮酒的人群，需警惕此类风险。 缓解疼痛（如头痛、牙痛、运动后损伤性疼痛）和治疗发热； 原发性痛经； 骨关节疾病引起的关节肿痛。 2 肾功能损伤 已有肾脏疾病者、老年人、脱水或血容量不足者、长期大剂量用药者、联用其他肾毒性药物者、心力衰竭及高血压患者，出现肾功能损伤的风险 更高。 布洛芬导致上述不良反应的比例因人群和用药条件 ...

四川在线记者 魏冯 近日，国家药品监督管理局决定对孟鲁司特制剂（包括孟鲁司特钠片、孟鲁司特钠咀嚼片、孟鲁司特钠 颗粒和孟鲁司特钠口溶膜）说明书内容进行统一修订。警示语方面，说明书修订建议应包含以下内容： 在服用孟鲁司特的各年龄段患者中均报告了神经精神不良反应，其中包括个别严重反应如抑郁和自杀倾 向等。 用药期间需密切看护患者，应详细告知医生既往神经或精神系统相关病史 应对国家药品监督管理局要求增加的相关警示语，重点在于用药过程中的监测与观察。赵艳分析，本次 公告提示的精神系统紊乱包括攻击性行为或敌对性的兴奋、焦虑、抑郁、方向知觉丧失、注意力不集 中、夜梦异常、口吃（结巴）、幻觉、失眠、记忆损伤、精神运动过激（包括易激惹、烦躁不安和震 颤）、梦游、自杀的想法和行为（自杀）、抽搐；神经系统紊乱包括：眩晕、嗜睡、感觉异常触觉减退 及罕见的癫痫发作。 用药期间，家属或家长需密切看护，时刻关注患者的情绪和行为变化，注意有无上述异常情况出现，以 及异常情况的出现与服药有无时间关系。一旦出现疑似神经精神相关不良反应，应及时告知医生并评估 停药，必要时调整治疗方案。 赵艳还提醒，儿童使用孟鲁司特前，家长应详细告知医生既往是否 ...

Core Points - A 63-year-old woman experienced severe abdominal pain, nausea, and vomiting for a month, initially attributing it to stress, but was later diagnosed with gastric bezoars after a gastroscopy revealed a large stone in her stomach [3][10][14] - The patient had lost 18 kilograms over the past year due to the use of semaglutide, a GLP-1 receptor agonist, which is known for its weight loss and diabetes management effects [3][15] - The treatment for the gastric stone involved consuming 3 liters of sugar-free cola within 12 hours, which successfully dissolved the stone, highlighting an unconventional yet effective method for treating gastric bezoars [10][14] Summary by Sections Patient Background - The patient had a history of multiple health issues, including type 2 diabetes, hypertension, and chronic kidney disease, and was on 16 different medications [3][14] - Weight loss was significant, dropping from 93 kg to 75 kg, with an accelerated rate of loss in the last month [3][14] Diagnosis - The abdominal pain was attributed to either a peptic ulcer or gastric stones, with the latter confirmed through gastroscopy [3][8] - Gastric stones are formed from undigested materials and can cause symptoms like abdominal pain and nausea [8][10] Treatment - The unconventional treatment involved the patient drinking sugar-free cola, which was effective in dissolving the gastric stone [10][14] - The patient was advised to continue with pain management using opioids while discontinuing semaglutide during her hospital stay [14] Implications for Semaglutide - Semaglutide, while effective for weight loss and diabetes management, can lead to adverse effects such as nausea and delayed gastric emptying, potentially resulting in gastric stones [15][16] - The discussion around the use of semaglutide raises questions about its safety and efficacy, especially when used for weight loss without medical supervision [15][17]