Group 1 - The core point of the article is that Yisi Biopharmaceutical (Shanghai) Co., Ltd. is considering an IPO in Hong Kong and is currently collaborating with advisors to prepare for the listing, with details regarding the scale and timing still under discussion [1] - Yisi Biopharmaceutical was established in 2020 and is headquartered in Shanghai, focusing on biopharmaceuticals for brain diseases, specifically targeting central nervous system disorders such as epilepsy, insomnia, and Parkinson's disease [1] - The company aims to translate cutting-edge science into innovative solutions that benefit patients [1] Group 2 - Yisi Biopharmaceutical has received investments from various notable entities, including Tonghe Yucheng, Ruentex Group, KB Investment, WTT Investment, Mubadala Investment Company, HBM Healthcare Investments, Goldman Sachs, and 6 Dimensions Capital [1]

Core Insights - The article discusses the groundbreaking achievements in the "Whole Brain Mesoscopic Neural Connectivity Atlas" project initiated by the Chinese Academy of Sciences, which has produced significant research results published in prestigious journals like "Cell" and "Neuron" [3][4][5] Group 1: Mesoscopic Brain Atlas - The mesoscopic brain atlas is defined as a representation that lies between macro and micro scales, detailing components of the brain such as individual neurons, neural networks, brain regions, and functional areas at the resolution of single neurons [3][4] - Over 300 scientists utilized domestically developed high-precision optical brain imaging technologies over five years to create multiple mesoscopic brain maps covering key species including reptiles, birds, rodents, non-human primates, and humans [3][5] Group 2: Technological Innovations - The most significant breakthrough in the published results is the innovation in the technical system, particularly the development of single-cell resolution spatial transcriptomics technology, which allows for the simultaneous acquisition of cellular spatial location and gene expression information [6] - This technology enables researchers to create detailed maps of brain regions, such as the hippocampus, identifying specific cell types and their roles in diseases like Alzheimer's, thus providing new biomarkers for early diagnosis and differential diagnosis [6][8] Group 3: Future Applications - The research aims to advance from small animals to non-human primates, with the ultimate goal of mapping the human brain at the mesoscopic level, which could lead to significant advancements in understanding brain diseases and developing predictive models for brain health [8][9] - The potential applications of the mesoscopic brain atlas extend beyond academic research, envisioning scenarios where brain diseases could be predicted like weather forecasts, and artificial intelligence could mimic human thought processes [8][9]