Core Viewpoint - The article emphasizes the importance of aligning meal times with the body's biological clock to effectively manage weight and reduce obesity risk, highlighting recent research on time-restricted feeding (TRF) and its effects on metabolism and energy expenditure [6][18][20]. Summary by Sections Obesity and Eating Habits - With rising living standards, the pursuit of delicious food has increased, leading to a rise in obesity rates, making weight loss a focal point of social concern and medical research [6]. Time-Restricted Feeding Research - A study published in the journal "Science" explores the biological mechanisms of time-restricted feeding in mice, indicating that eating during inactive periods (daytime) leads to significant weight gain compared to active periods (nighttime) [7][9]. - The research shows that energy consumption decreases when mice eat during inactive periods, contributing to weight gain despite similar food intake and digestion efficiency [9]. Metabolic Implications - Active period eating enhances energy expenditure by increasing glycolysis and the tricarboxylic acid cycle in fat tissues, which helps in weight management [11]. - Disruption of the biological clock due to high-fat diets affects the expression of clock genes in fat tissues, indicating that inappropriate eating times can disturb fat metabolism and increase obesity risk [13]. Genetic Factors and Thermogenesis - The study identifies key genes related to thermogenesis in fat tissues, showing that enhancing fat cell thermogenesis can help control weight gain during inactive periods [15][17]. - The absence of the ZFP423 gene promotes fat thermogenesis and improves energy metabolism, suggesting that proper meal timing can maximize fat tissue thermogenesis and minimize weight gain [17]. Practical Recommendations - To achieve effective weight loss, meal times should align with the body's biological rhythms, advocating for eating during the day when the biological clock is active and reducing or avoiding food intake at night [18][19].