Core Viewpoint - The article emphasizes the importance of aligning meal times with the body's biological clock to effectively manage weight and reduce obesity risk, highlighting recent research on time-restricted feeding (TRF) and its effects on metabolism and energy expenditure [6][18][20]. Summary by Sections Obesity and Eating Habits - With rising living standards, the pursuit of delicious food has increased, leading to a rise in obesity rates, making weight loss a focal point of social concern and medical research [6]. Time-Restricted Feeding Research - A study published in the journal "Science" explores the biological mechanisms of time-restricted feeding in mice, indicating that eating during inactive periods (daytime) leads to significant weight gain compared to active periods (nighttime) [7][9]. - The research shows that energy consumption decreases when mice eat during inactive periods, contributing to weight gain despite similar food intake and digestion efficiency [9]. Metabolic Implications - Active period eating enhances energy expenditure by increasing glycolysis and the tricarboxylic acid cycle in fat tissues, which helps in weight management [11]. - Disruption of the biological clock due to high-fat diets affects the expression of clock genes in fat tissues, indicating that inappropriate eating times can disturb fat metabolism and increase obesity risk [13]. Genetic Factors and Thermogenesis - The study identifies key genes related to thermogenesis in fat tissues, showing that enhancing fat cell thermogenesis can help control weight gain during inactive periods [15][17]. - The absence of the ZFP423 gene promotes fat thermogenesis and improves energy metabolism, suggesting that proper meal timing can maximize fat tissue thermogenesis and minimize weight gain [17]. Practical Recommendations - To achieve effective weight loss, meal times should align with the body's biological rhythms, advocating for eating during the day when the biological clock is active and reducing or avoiding food intake at night [18][19].

Core Insights - Metoday's "Day and Night Whitening Kit" has successfully passed rigorous testing by the prominent evaluation platform "Dad Evaluation," establishing itself as the only orally ingested whitening product to achieve this certification [1][2]. Group 1: Product Testing and Validation - The oral beauty market is expanding, yet consumer concerns regarding product safety and efficacy persist. Metoday proactively submitted its product for scientific validation to build market trust [2]. - The testing process adhered to newly established industry standards, which were released on March 22, 2024, after Metoday initiated the testing on March 6, 2024. A "three-tier verification system" was implemented, including a 28-day washout period, double-blind trials, and independent third-party laboratory screening [2][3]. - The 28-day washout period required participants to refrain from using any whitening products to eliminate residual effects from previous skincare routines [2]. Group 2: Testing Methodology - A total of 70 volunteers participated in the double-blind experiment, divided into a test group using the Metoday kit and a control group using a placebo. Both groups underwent a four-week and eight-week trial, followed by a ten-day data analysis period [3]. - The independent third-party laboratory conducted extensive safety tests covering 50 hormone tests, 4 heavy metals, 3 preservatives, 7 artificial colorants, and 6 microbiological indicators, all of which met the required safety standards [3]. Group 3: Research and Development Philosophy - The development of the "Day and Night Whitening Kit" is based on the Nobel Prize-winning theory of "circadian rhythms," which was awarded in 2017. Metoday has researched the relationship between skin metabolism and whitening pathways, leading to the creation of the "Morning Protection + Night Recovery" model [4]. - The kit consists of two products: the daytime small white bottle focusing on protection and the nighttime small purple bottle focusing on recovery, providing a targeted whitening solution [4][5][7]. Group 4: Key Ingredients - The daytime small white bottle targets melanin production through five key pathways, featuring star ingredients such as patented white tomato extract, root skin extract, cherry extract, and niacinamide [5][6]. - The nighttime small purple bottle emphasizes cellular repair and regeneration, containing key ingredients like GABA, high-concentration hyaluronic acid, rice bran extract, patented PQQ, and wheat germ extract [7]. Group 5: Market Implications - Metoday's founder, Michael Kerr, emphasizes the importance of combining natural gifts with scientific rigor in health products. The rigorous testing process and adherence to the latest standards provide a practical example of validating the safety and efficacy of oral beauty products [11]. - As the oral beauty market continues to grow, consumer demand for efficacy and safety is increasing. Brands like Metoday that prioritize scientific development may inject more scientific momentum into the future health consumption market [11].

Core Insights - Metoday's "Day and Night Whitening Kit" has successfully passed rigorous testing by the prominent evaluation platform "Old Dad Evaluation," establishing itself as the only oral whitening product to achieve this certification [1][2]. Group 1: Product Testing and Validation - The oral beauty market is expanding, but consumer concerns about product safety and efficacy persist. Metoday chose to submit its product for scientific validation to build market trust [2]. - The testing process utilized a three-tier verification system: a 28-day washout period, a double-blind experiment, and independent third-party laboratory screening [2][3]. - The entire testing process took 182 days and incurred a total cost of approximately 305,093.2 yuan (about 30 million) [3]. Group 2: Research and Development Philosophy - The development of the "Day and Night Whitening Kit" is based on the "Circadian Rhythm" theory, which won the Nobel Prize in Physiology or Medicine in 2017. Metoday has integrated this theory into its product development [4]. - The kit includes two products: a daytime protection serum and a nighttime recovery serum, each targeting specific skin needs [4]. Group 3: Key Ingredients and Formulations - The daytime serum focuses on protection against melanin production, featuring key ingredients such as patented white tomato extract, root skin extract, cherry extract, and niacinamide [5][6]. - The nighttime serum emphasizes deep cellular repair and regeneration, containing ingredients like GABA, high-concentration hyaluronic acid, rice bran extract, patented PQQ, and wheat germ extract [7]. Group 4: Market Implications - Metoday's founder, Michael Kerr, emphasizes the importance of combining natural ingredients with scientific rigor in health products. The successful testing of the oral beauty product may enhance consumer confidence in the growing market [11].

Core Findings - A recent study from New Zealand indicates that human immune function is more active and efficient during the day due to a biological clock mechanism that responds to light [1][2] - The research supports previous scientific views that circadian rhythm disruptions, such as night shifts and jet lag, may increase infection risks [1] - Neutrophils, a key immune cell type, are controlled by circadian rhythms and are more effective at responding to infections during the day [1] Research Methodology - Researchers used zebrafish as a model organism due to their high genetic similarity to humans and transparent bodies, which allow for real-time tracking of cell behavior [1] - The study involved capturing images of neutrophils killing bacteria at different times of the day, revealing higher efficiency during daylight hours [1] - Gene editing was employed to disable the biological clock of neutrophils, demonstrating that these immune cells possess a light-regulated internal circadian rhythm that enhances their bacterial killing ability [1] Implications for Treatment - The discovery of this biological clock mechanism in neutrophils not only aids in understanding immune system operations but also opens new avenues for treating various inflammatory diseases [2] - Future research will focus on how light signals regulate the rhythms of these immune cells at the molecular level, potentially leading to the development of new therapies to enhance immunity [2]

Core Viewpoint - The article emphasizes the importance of understanding individual sleep types, which are largely determined by genetics, and the need for people to align their sleep schedules with their natural preferences to avoid health risks [1][3]. Group 1: Understanding Sleep Types - Sleep types refer to an individual's preferred sleep and activity periods, influenced by genetics for about 40% to 50% [3]. - There is a significant societal bias favoring early risers, often leading to misconceptions about night owls being lazy or needing less sleep [1][2]. - The concept of "competitive sleep deprivation" is prevalent, where individuals boast about needing little sleep, despite the fact that most people require 7 to 9 hours of rest per night [1]. Group 2: Effects of Misaligned Sleep - Night owls forced to wake early may not actually need less sleep; they are simply sleeping at the wrong times [2]. - Research indicates that night owls face a 30% higher risk of diabetes, nearly double the likelihood of mental health issues like depression, and a 10% higher mortality rate compared to early risers [5]. - Increased caffeine consumption is common among those who struggle to align their sleep with societal expectations [5]. Group 3: Recommendations for Night Owls - To mitigate the risks associated with misaligned sleep, night owls should maintain consistent sleep-wake times within a 25-minute variance [5]. - Utilizing morning light exposure can help adjust the biological clock, and low-dose melatonin may assist in falling asleep earlier [5]. - Optimizing the sleep environment and carefully managing caffeine intake are also recommended strategies [5][6].