针对药品领域垄断行为的特点与难点，市场监管总局今年专门制定并出台了《关于药品领域的反垄断指 南》。该指南明确了药品联合涨价、滥用支配地位推高药价、限定交易等典型垄断行为的认定规则，为 医药企业划清了竞争红线，提供了明晰的合规指引。通过"查处一个案件、规范一个行业"，发挥重大典 型案件的警示教育和示范作用，推动全行业反垄断合规意识提升，实现系统治理、源头防范。 打击药品垄断非一部门之事。市场监管总局加强与卫生健康、公安、医保、药监等部门的协同联动，在 线索发现、调查取证、信息共享、联合惩戒等方面形成合力。执法的最终成效体现在终端药价的变化 上。据介绍，通过查办相关垄断案件，有效推动了相关药品价格的大幅下降。 新京报讯(记者陈琳)近年来，部分领域药品垄断行为多发，推高药价、扰乱市场，直接加重了群众用药 负担。12月17日，在市场监管总局召开的民生领域反垄断执法专项行动新闻发布会上，市场监管总局反 垄断一司副司长刘健介绍，近三年来，总局已累计查处药品领域垄断协议、滥用市场支配地位案件12 件，罚没款总额超过24亿元人民币。 对药品领域垄断行为坚持"露头就打"，执法重点始终聚焦于短缺药、急抢救药、常用药等关键品种，守 ...

Core Viewpoint - The article highlights the issue of pharmaceutical companies engaging in price-fixing and monopolistic practices, leading to significant price increases for essential medications, particularly the drug "新斯的明" (Neostigmine), which has seen price hikes of 11 to 21 times due to collusion among three companies [2][3][19]. Group 1: Price Manipulation and Regulatory Actions - Xianju Pharmaceutical was fined 195 million yuan for its involvement in a monopoly case related to dexamethasone phosphate raw materials [1]. - The price of Neostigmine injection surged from 2-3 yuan to over 30 yuan per unit, representing an increase of over 10 times [6][10]. - The sales revenue of Neostigmine in public medical institutions exceeded 3 billion yuan in 2020, with a year-on-year growth of 446.81% [10]. Group 2: Impact on Patients and Market Dynamics - Neostigmine is critical for treating myasthenia gravis and has no alternative medications, making its price increase particularly harmful to patients [4][14][16]. - The drug was included in the National Shortage Drug List, which pharmaceutical companies used as a pretext for price hikes [11][13]. - By the end of 2024, Neostigmine was included in the tenth batch of centralized procurement, with prices dropping to below 1 yuan per unit, exposing the previous price inflation as unjustified [17][18]. Group 3: Monopolistic Practices and Legal Framework - The collusion among the three companies involved not only price increases but also market division to maintain their market shares [19][20]. - The penalties for monopolistic behavior have historically been light, with the revised Anti-Monopoly Law in 2022 introducing personal liability for executives, marking a shift in enforcement [5][29][35]. - The fines imposed on companies often do not reflect the substantial illegal profits gained from monopolistic practices, leading to calls for stricter enforcement and higher penalties [27][30].

Core Viewpoint - The case involving the price manipulation of the anesthetic drug, Xinsiming Injection, reveals a significant increase in its price due to collusion among major sales companies, leading to penalties exceeding 200 million yuan for the involved parties [1][2][10]. Group 1: Price Manipulation and Market Impact - Xinsiming Injection's price surged by 11-21 times due to a collusion agreement among Shanghai Xinyi United Pharmaceutical Co., Ltd., Henan Runhong Pharmaceutical Co., Ltd., and Chengdu Huixin Pharmaceutical Co., Ltd. [1][10] - The drug, which is essential for surgeries and other medical treatments, was previously priced between 3.56-6.8 yuan per unit before the collusion, and later reached prices of 71.5 yuan, 36 yuan, and 35.8 yuan in different markets [6][7]. - The total procurement amount for Xinsiming Injection in hospitals was reported at 776 million yuan in 2021, with sales revenue for the drug reaching 511 million yuan for the same year [8]. Group 2: Regulatory Actions and Penalties - The Shanghai Municipal Market Supervision Administration imposed a total fine of 222 million yuan on the three companies involved, with Xinyi United facing the heaviest penalty of 165 million yuan [9][11]. - The case marked the first instance of individual accountability under the revised Anti-Monopoly Law, with personal fines imposed on individuals responsible for the collusion [12]. - Following the investigation, Xinsiming Injection was included in the national centralized procurement list, resulting in a significant price drop to between 0.56 yuan and 0.91 yuan per unit [14]. Group 3: Company Background and Previous Violations - Shanghai Xinyi United and its parent company, Shanghai Pharmaceuticals Holding Co., Ltd., have a history of regulatory violations, including previous penalties for accounting irregularities and price manipulation [15][17]. - The recent penalties are not expected to have a significant impact on Shanghai Pharmaceuticals' overall operations, as the affected business unit contributes less than 1% to the company's total revenue [15].