Core Viewpoint - The article discusses the potential drug interactions of Semaglutide, emphasizing the importance of understanding how it may interact with other commonly used medications, which could affect its efficacy or increase the risk of side effects [2][4]. Group 1: Severe Drug Interactions - Semaglutide has significant interactions with several classes of medications, particularly insulin and other diabetes drugs, which may lead to hypoglycemia if used together [5]. - Patients using anticoagulants and antiplatelet drugs, such as Warfarin and Aspirin, should be cautious as these can increase the risk of gastrointestinal bleeding and may alter the absorption and metabolism of Semaglutide [6][7]. - Opioid medications may have moderate interaction risks with Semaglutide, potentially affecting the absorption and elimination of these pain relievers due to delayed gastric emptying [8]. Group 2: Moderate Drug Interactions - Statins, such as Atorvastatin and Simvastatin, may have moderate interaction potential with Semaglutide, possibly affecting their absorption in the intestine [12]. - Hormonal contraceptives may be less effective when used with Semaglutide, increasing the risk of unintended pregnancy [15][16]. - Thyroid medications and certain antiepileptic drugs may require monitoring and potential dosage adjustments when used alongside Semaglutide due to absorption changes [17][18]. Group 3: Over-the-Counter Drug Interactions - Common over-the-counter medications, including NSAIDs and laxatives, may exacerbate gastrointestinal side effects associated with Semaglutide, such as diarrhea and nausea [20][21].