Group 1 - The article discusses the recruitment of 7 postdoctoral researchers for projects related to "Basic and Interdisciplinary Breakthroughs (Synthetic Multi-cell Genomes)" and "National Major Instrument Development Projects (High-Precision Synthesis Systems for Long Fragments of DNA)" [3] - Candidates with backgrounds in epigenomics, strain construction, and enzyme catalysis are particularly encouraged to apply, especially those who have recently completed or are about to complete their PhD [3] - The age limit for applicants is generally set at 35 years, and candidates should possess strong academic qualifications and research capabilities [3] Group 2 - The hiring package includes competitive salary and performance rewards, support for applying to national postdoctoral programs, and benefits such as children's education and social insurance [4] - The institution offers assistance in applying for various research projects, including the National Natural Science Foundation and postdoctoral programs [4] - A good research platform and opportunities for international collaboration and exchange are provided [4] Group 3 - Application materials must be combined into a single PDF and sent to the specified email address, with a clear subject line indicating the position and applicant's name [5] - Required documents include a personal resume, a personal statement outlining research interests and development plans, and contact information for three referees along with recommendation letters [5] - The recruitment is ongoing until positions are filled, and self-recommendations are welcomed [5]

Core Insights - The research teams from the Chinese Academy of Sciences and Xiamen University discovered a metal isomerase that catalyzes the oxidative cleavage of hexoses, revealing a sophisticated strategy for microbial metabolic balance through "one enzyme, dual functions" [1] Group 1: Research Findings - The study published in the journal Nature-Catalysis highlights the importance of hexose carbon-carbon bond cleavage as a key step in metabolism [1] - The research focused on the natural product "cycloheximide," analyzing the structure and function of the key enzyme Art22, which has significant antibacterial activity [1] - Art22 features a typical TIM barrel structure and can catalyze both the isomerization of ketohexoses and the oxidative cleavage of hexoses into short-chain compounds, releasing carbon dioxide [1] Group 2: Enzyme Functionality - Art22 performs isomerization and oxidative cleavage sequentially at the same active site, playing dual roles of "synthesis" and "degradation" within the microbial cell [1] - This dual functionality helps promote the generation of antibacterial molecules while simultaneously inactivating toxic byproducts, maintaining a delicate balance within the cell [1] Group 3: Implications - The research provides a novel understanding of sugar oxidative cleavage mechanisms, expanding the knowledge of metal enzyme catalytic reactions [1] - It offers new insights into microbial metabolic regulation and serves as a theoretical basis for the development of natural product drugs and enzyme engineering applications [1]

Core Insights - The research team discovered a metal isomerase with a new function in catalyzing hexose oxidative cleavage, revealing a sophisticated strategy for microbial metabolic balance through "one enzyme, dual function" [1][2] Group 1: Research Findings - The study elucidates a novel mechanism for carbohydrate oxidative cleavage, expanding the understanding of metal enzyme catalytic reactions [2] - The enzyme Art22, derived from the natural product "circular enediyne," exhibits a typical TIM barrel structure and can catalyze both hexose isomerization and oxidative cleavage [1] - Art22 performs isomerization and oxidative cleavage sequentially at the same active site, playing dual roles in synthesizing antibacterial molecules and deactivating toxic byproducts within the microbial cell [1]