以下文章来源于肥胖世界ObesityWorld ，作者欢迎订阅 肥胖世界ObesityWorld . 《肥胖世界》Obesity World - 同步传真肥胖及代谢国际新学术进展，为医学减重临床、教研人员搭建一座与国际接轨的桥梁，「每医健」旗下内容平台。 这种记忆的形成，源于肥胖经历引发的表观基因组变化。这些化学标记能够在细胞的DNA和蛋白质上增减，从而调控基因的活跃程度。对于 脂肪细胞而言，这些基因表达的变化会让它们难以恢复正常功能。 《Nature》杂志今日刊登的最新研究显示，这种损伤和基因活性的异常，即使体重已经恢复到健康范围，也会在很长时间内持续存在。 这项研究的共同作者、瑞士苏黎世联邦理工学院生物学家Laura Hinte指出，研究结果显示，想要减肥的人常常需要长期的支持和管理，才能 避免体重反弹。"这意味着你可能需要更多的帮助，"她说，"这绝不是你的错。" 印第安纳大学医学院新陈代谢和表观基因组学专家Hyun Cheol Roh补充道，虽然我们早已知道体重下降后容易反弹，但"到底是怎么发生的、 为何会发生，几乎像个谜团。"他认为，这项新研究"揭示了分子层面上的具体机制，非常令人兴奋。" 为了解释减 ...

Core Viewpoint - The study of Maria Branyas Morera, the world's oldest verified living person, provides insights into aging and longevity, highlighting the potential for distinguishing molecular changes due to aging from those related to health conditions [2][4][6]. Group 1: Research Findings - The research team conducted a high-throughput multi-omics study on Maria Branyas Morera, analyzing her genome, transcriptome, metabolome, proteome, microbiome, and epigenome, with results to be published in Cell Reports Medicine [2][11]. - One major finding is the ability to differentiate molecular changes due to aging from those caused by poor health, as evidenced by her unusually short telomeres without associated age-related diseases [6][11]. - Genetic analysis revealed she possesses mutations that are known to prevent cardiovascular diseases, cognitive decline, and diabetes, while lacking mutations linked to increased risks of certain diseases like Alzheimer's [6][11]. Group 2: Health and Lifestyle Factors - Maria Branyas Morera's blood tests showed low levels of "bad" cholesterol and high levels of "good" cholesterol, indicating efficient lipid metabolism and a strong immune system with low inflammation markers [7]. - Her gut microbiome was found to be similar to that of much younger individuals, with a high abundance of beneficial bacteria, potentially linked to her diet of three servings of yogurt daily [7][8]. - Lifestyle factors such as adherence to a Mediterranean diet and regular exercise may also contribute to her longevity [8].