Core Viewpoint - Shanghai Baoji Pharmaceutical Co., Ltd. is preparing for an IPO on the Hong Kong Stock Exchange, with funds primarily allocated for the development and commercialization of core products and expansion of production capacity [1][2]. Group 1: IPO Details - The company has submitted its hearing materials and is expected to list soon, with CITIC Securities and Cathay Securities acting as joint sponsors [1]. - The funds raised will support clinical trials and regulatory filings for core products KJ017, KJ103, and SJ02 in various regions [1]. Group 2: Product Development - The company focuses on four strategic areas: large-volume subcutaneous delivery, antibody-mediated autoimmune diseases, assisted reproduction, and recombinant biopharmaceuticals [2]. - It has developed 12 research products, including three core products, with SJ02 already approved by the National Medical Products Administration (NMPA) [2]. - KJ017 is in the NDA stage, while KJ103 is in Phase III clinical trials [2]. Group 3: Technology and Production - The company aims to optimize its proprietary synthetic biology technology platform to develop new drug candidates [1]. - Plans include enhancing and expanding production capacity, including the construction of a new production base in Shanghai and upgrading existing facilities [1].

Core Viewpoint - Sanwei Biotech is actively advancing the industrialization and market expansion of diversified products, including allulose, tagatose, mannitol, and others, to enhance its product structure and overall business resilience [2]. Product Development - Allulose: The company has launched a production capacity of 10,000 tons, with an additional 10,000 tons under construction. Sales from January to September have shown significant year-on-year growth, meeting the needs of domestic clients like Nayuki Tea and steadily increasing overseas demand [2]. - Tagatose: Approved as a new food ingredient in China since 2014 and recognized in multiple countries, the company is optimizing production processes to reduce costs and enhance market potential. Tagatose and allulose both possess health benefits related to blood sugar control and gut microbiota regulation, with ongoing efficacy research in collaboration with Binzhou Medical University [2]. - Mannose: The company has small-scale production capabilities and is in the process of applying for domestic and overseas certifications. Mannose is gaining attention for its applications in medical research and health nutrition [2]. - Mannitol: The company has developed a cost advantage through new production processes and plans to gradually introduce it to the market [2]. - Reb M: The market acceptance of Reb M is increasing through continuous promotion, and the company has also developed sweet tea glycosides from regular steviol glycosides, with mature processing technology [2]. - Cosmetic Ingredients: The company leverages its synthetic biology technology to develop glycerol glycosides, ascorbic acid glucosides, and alpha arbutin, expanding its product applications in the daily chemical sector [2]. Strategic Goals - The gradual advancement of these products will help the company maintain its core competitiveness in erythritol while enhancing product diversity and improving overall business stability and risk resistance [2].

近日，工业和信息化部、国家发展改革委联合公示全国首批生物制造中试能力建设平台名单，全国共有 43家单位入选。其中，由传化集团与国有资本合作建设运营的"杭州合成生物产业中试（验证）中心"入 选，成为浙江省代表性平台之一。 此次全国首批中试平台能力培育名单的发布，旨在加快补齐我国生物制造中试环节短板，推动产业体系 完善与创新成果高效转化。 杭州合成生物产业中试（验证）中心位于萧山绿色制造产业园，中心专注于合成生物技术中试验证与放 大，覆盖生物制造化学品、酶制剂、食品及添加剂等多个领域，致力于打造集技术中试、成果验证、工 艺放大和产业转化于一体的综合性平台。 目前，该中试（验证）中心依托传化集团先进制造业体系与传化科技城创新平台已建和在建各类中试应 用场景与试验体系，配备从0.1升小试到1000升中试的多级发酵、催化与分离设备，可实现从菌种设 计、发酵放大、酶催化转化到产品纯化的全流程开发验证。 在上游环节，该中试（验证）中心建设了自主开发的高通量生物铸造平台，集成液质联用、PCR等先进 分析检测设备，具备菌种设计、高通量测试及工艺验证的核心能力。平台还积极推动AI技术在合成生 物学中的应用，为工艺优化和参数控制提 ...

Group 1 - The China Securities Regulatory Commission (CSRC) has requested Huaheng Biological (688639.SH) to provide supplementary information regarding its technology export business and compliance over the past three years [1] - Huaheng Biological has submitted a listing application to the Hong Kong Stock Exchange, with Huatai International as the sole sponsor [1] - The CSRC has outlined specific areas for Huaheng Biological to clarify, including the status of its technology export business, compliance with regulations, and the use of raised funds for overseas investments [1] Group 2 - Huaheng Biological is a pioneer in synthetic biology, focusing on the research, large-scale production, and commercialization of bio-based products [2] - The company is recognized as one of the most comprehensive enterprises globally in commercial applications of bio-based products through synthetic biology [2] - Huaheng Biological is the first company to industrialize the anaerobic fermentation of a series of amino acids, including L-Alanine and L-Valine, and holds the largest market share for these products globally as of 2024 [2]

Group 1 - The China Securities Regulatory Commission (CSRC) has requested Huaheng Biological (688639.SH) to provide supplementary information regarding its technology export business and compliance over the past three years [1] - Huaheng Biological has submitted its listing application to the Hong Kong Stock Exchange, with Huatai International as the sole sponsor [1] - The CSRC has outlined specific areas for Huaheng Biological to clarify, including the status of its technology export business, compliance with regulations, and the use of raised funds for overseas investments [1] Group 2 - Huaheng Biological is a pioneer in synthetic biology, focusing on the research, large-scale production, and commercialization of bio-based products [2] - The company is recognized as one of the most comprehensive enterprises globally for commercial applications of bio-based products through synthetic biology [2] - Huaheng Biological is the first company in the world to industrialize the anaerobic fermentation of a series of amino acids, including L-Alanine and L-Valine, and holds the largest market share for these products globally as of 2024 [2]

Group 1 - The China Securities Regulatory Commission (CSRC) has requested Huaheng Biological (688639.SH) to provide supplementary information regarding its technology export business and compliance over the past three years [1] - Huaheng Biological has submitted its listing application to the Hong Kong Stock Exchange, with Huatai International as the sole sponsor [1] - The CSRC has outlined specific areas for Huaheng Biological to clarify, including the status of its technology export business, compliance with regulations, and the use of raised funds for overseas investments [1] Group 2 - Huaheng Biological is a pioneer in synthetic biology, focusing on the research, large-scale production, and commercialization of bio-based products [2] - The company is recognized as one of the most comprehensive enterprises globally in commercial applications of bio-based products through synthetic biology [2] - Huaheng Biological is the first company to industrialize the anaerobic fermentation of a series of amino acids, including L-Alanine and L-Valine, and holds the largest market share for these products globally as of 2024 [2]

Core Viewpoint - The company, Langkun Technology (301305.SZ), has stated that it is currently not utilizing synthetic biology technology to produce D-Allulose sugar [1] Group 1 - The company is actively engaging with investors through an interactive platform [1] - There is a focus on synthetic biology technology within the industry, particularly regarding its applications in sugar production [1]

Core Viewpoint - The company has not utilized synthetic biology technology for the production of D-allulose sugar [1] Group 1 - The company is currently not engaged in the production of D-allulose sugar using synthetic biology technology [1]

Core Viewpoint - The company is actively exploring technological improvements in synthetic biology applications for pharmaceutical intermediates and active pharmaceutical ingredients to reduce production costs and environmental pollution [2] Group 1 - The company is focusing on technological exploration in synthetic biology [2] - The aim is to lower production costs [2] - The initiative also targets the reduction of environmental pollution [2]

Core Viewpoint - Rhein Biotech is a leading company in the global plant extract industry, focusing on natural health products and possessing advanced extraction technology and a full industry chain advantage [1] Group 1: Business Performance - In Q3 2025, Rhein Biotech reported revenue of 1.272 billion yuan, ranking 12th in the industry, with the industry leader, Meihua Biological, generating 18.215 billion yuan [2] - The net profit for the same period was 79.1918 million yuan, placing the company 17th in the industry, while the top performer, New Hope Liuhe, achieved a net profit of 5.354 billion yuan [2] Group 2: Financial Ratios - As of Q3 2025, Rhein Biotech's debt-to-asset ratio was 36.56%, higher than the industry average of 28.46%, indicating a relatively heavy debt burden [3] - The gross profit margin was 25.00%, lower than the industry average of 28.77%, suggesting a smaller profit space for the company's products [3] Group 3: Executive Compensation - The chairman and general manager, Xie Yongfu, received a salary of 938,000 yuan in 2024, an increase of 18,500 yuan from 2023 [4] Group 4: Shareholder Information - As of September 30, 2025, the number of A-share shareholders decreased by 1.66% to 46,000, while the average number of circulating A-shares held per account increased by 31.16% to 16,000 [5] Group 5: Strategic Developments - Rhein Biotech aims to integrate "natural extraction + synthetic biology" as a strategic goal, having obtained multiple patents and launched a synthetic biology workshop [5] - The company has achieved mass production capability for steviol glycosides and is expected to receive FDA GRAS certification for left-handed β-glucan in 2025 [5] - Revenue forecasts for 2025-2027 are projected at 2.081 billion, 2.480 billion, and 2.996 billion yuan, with corresponding net profits of 213 million, 288 million, and 396 million yuan [5] Group 6: Market Outlook - According to Huaxin Securities, Rhein Biotech's revenue is expected to grow steadily in Q1 2025, although net profit margins may decline due to rising costs [6] - The company’s synthetic biology products have made significant progress, with FDA GRAS certification achieved for a synthetic steviol glycoside product [6]