Core Viewpoint - The article emphasizes the detrimental effects of a sedentary lifestyle, highlighting that just ten days without exercise can lead to significant metabolic and cognitive decline, including insulin resistance and memory impairment [6][12]. Group 1: Impact of Sedentary Lifestyle - A study led by Dr. Nathan Kerr from the University of Missouri reveals that ten days of inactivity can accelerate insulin resistance and negatively affect memory function [6]. - The research involved a hindlimb immobilization experiment on four-month-old female Wistar rats, demonstrating that lack of exercise triggers a "degenerative storm" in both the body and brain [6][8]. Group 2: Cognitive Decline Mechanisms - The hippocampus shows signs of insulin resistance after just ten days of inactivity, disrupting glucose metabolism and leading to mitochondrial dysfunction and increased reactive oxygen species (ROS) [8][9]. - Abnormal levels of amyloid precursor protein (APP) and tau protein, markers for Alzheimer's disease, were observed, indicating a potential risk for cognitive decline [9]. Group 3: Iron Metabolism Imbalance - The study found that muscle inactivity leads to abnormal iron accumulation in muscles while causing a significant decrease in iron levels in the brain, creating a negative correlation that exacerbates oxidative stress and insulin resistance in the hippocampus [11]. Group 4: Modern Lifestyle Concerns - The article notes that modern individuals sit for over eight hours daily, contributing to a surge in type 2 diabetes rates and a decrease in healthy life expectancy post-65 years [12]. - Insulin resistance from lack of exercise is linked to both physical and cognitive health deterioration, potentially triggering early onset of Alzheimer's disease [12]. Group 5: Recommendations for Physical Activity - The article suggests that exercise is essential for maintaining cognitive function, proposing simple methods to incorporate more movement into daily life, such as taking stairs, walking, and outdoor activities [16]. - It emphasizes that immediate action yields the greatest health benefits, particularly in middle age to prevent cognitive decline [16][14].