Core Viewpoint - Cancer immunotherapy has transformed cancer treatment, but many patients do not respond. Activating innate immunity presents a promising method to enhance treatment efficacy, yet the specific signal kinases involved remain largely unknown [3]. Group 1: Research Findings - A recent study published in Nature Cancer identified CDK10 as a key driver of immune evasion in cancer cells, which suppresses antitumor immunity by limiting the production of immunostimulatory nucleic acids [3][4]. - The research utilized in vivo CRISPR screening to establish CDK10 as a critical inhibitory factor in tumor immune surveillance [4]. - CDK10 reduces the accumulation of double-stranded RNA and R-loops by phosphorylating DNMT1 and RAP80, thereby dampening the activation of innate immune pathways mediated by MDA5 and cGAS [4]. Group 2: Clinical Implications - The study confirmed that lower expression levels of CDK10 in tumors correlate with better responses to immunotherapy in cancer patients [5]. - These findings position CDK10 as a significant regulatory factor in tumor immunity and a potential therapeutic target [6]. Group 3: Related Commentary - A commentary published alongside the study in Nature Cancer highlighted that the activation of cytoplasmic nucleic acid sensors in tumor cells is a crucial early step in initiating antitumor immunity, although the mechanisms controlling their activity are not fully understood [6].

Core Viewpoint - The article highlights the achievements of prominent scientists awarded the Tengchong Science Prize, emphasizing their contributions to various fields of science and technology, particularly in quantum physics, biomedicine, and genetic research [3][7][10][12][15][17]. Group 1: Tengchong Science Prize - The Tengchong Science Prize was awarded for the first time in 2023, with recipients including Professors Lu Yuming and Zhang Feng [8]. - In 2024, the awardees were Professors Xue Qikun and Xie Xiaoliang [8]. - The prize is notable for being the first science and technology award initiated in mainland China with a single prize amount of 10 million RMB, focusing on significant breakthroughs in various scientific fields [17]. Group 2: Notable Awardees - Academician Pan Jianwei received the Tengchong Science Prize for his pioneering work in quantum optics and quantum information, making global secure quantum communication a feasible reality [3]. - Academician Xue Qikun's team discovered the quantum anomalous Hall effect, marking a significant experimental observation in physics [10]. - Academician Xie Xiaoliang is recognized for his foundational work in single-molecule biophysical chemistry and advancements in genome amplification technology, benefiting thousands of families with genetic disorders [12]. - Professor Lu Yuming is acknowledged as a pioneer in non-invasive prenatal testing, revolutionizing prenatal diagnostics and benefiting millions of pregnant women globally [15]. - Professor Zhang Feng is a leading figure in CRISPR-Cas gene editing technology, significantly impacting life sciences and molecular diagnostics [17]. Group 3: Tengchong Young Scientist Award - The Tengchong Young Scientist Award was established this year, covering ten subfields including mathematics, physics, materials science, and ecology [7]. - Notable recipients include Professor Wang Jianwei from Peking University and Professor Qian Xiaoshi from Shanghai Jiao Tong University, among others [7].