Core Insights - The research team led by Professor Xiao Yibei from China Pharmaceutical University has revealed a new immune mechanism by which bacteria resist phage infections, providing insights for the development of related drugs [1][2] Group 1: Immune Mechanism Discovery - Bacteria can suppress phage infection and propagation, challenging the previous belief that only higher organisms possess immune systems [1] - The study is based on the CRISPR-Cas system, which is a gene-editing technology that can cut genetic material at specific locations [1][2] Group 2: ATP Metabolism and Phage Resistance - The new mechanism involves depleting ATP, the energy factor within bacteria, which slows down the phage's ability to replicate [2] - Bacteria convert ATP into toxic ITP, which hinders phage replication due to insufficient energy [2] - A hydrolytic enzyme within bacteria further degrades ITP, allowing bacteria to detoxify and eventually recover after clearing phages during a 'dormant' state [2] Group 3: Implications for Future Research - The discovery highlights the intrinsic link between bacterial immunity and metabolic processes, enhancing the scientific community's understanding of gene-editing technologies [2] - This research provides important insights for the future development of anti-infection drugs [2]

Core Viewpoint - The article announces the launch of the open-access journal "Immunity & Inflammation," focusing on significant scientific issues and advancements in the fields of immunology and inflammation [2][4]. Group 1: Journal Overview - "Immunity & Inflammation" is co-edited by prominent figures in immunology, including Nobel laureates and leading researchers from various countries [2][5]. - The journal aims to bridge foundational insights with medical innovations, publishing high-quality original research, reviews, and highlights across basic, translational, and clinical research [6]. Group 2: Research Focus - The journal particularly welcomes studies exploring the dual nature of inflammation, inflammation-driven diseases, novel anti-inflammatory interventions, and groundbreaking findings in immune regulation [6]. - It encourages interdisciplinary research, including the use of artificial intelligence and digital health technologies, and aims to establish new standards in relevant research and practice areas [6]. Group 3: Editorial Commitment - The journal is committed to maintaining the highest standards of scientific ethics, integrity, transparency, and reproducibility [6][7]. - It invites global scientific communities to collaborate and contribute to making "Immunity & Inflammation" a vibrant and impactful academic platform [7].