新华财经上海7月28日电（谷青竹） 第二届湖区生命健康科学家大会日前在江苏省昆山市的淀山湖畔举 行。来自海内外逾200位顶尖科学家、临床专家、企业家及投资人汇聚一堂，为人类健康探寻"未来方 案"。 生物医药是苏州的"一号产业"。以此为发力点，昆山加速产业创新集群建设。据昆山发布的数据，截至 2023年5月，昆山市已有生物医药产业相关企业数超230家。作为昆山的南部门户、对接上海的桥头堡， 淀山湖镇深度把握长三角一体化战略机遇，着重发挥距离虹桥枢纽仅30分钟车程的同城化区位优势，及 拥有14公里黄金湖岸线的生态资源优势。"我们全力拓展'环淀山湖创新绿核'与'虹桥商务区动力核'的双 核效应。"淀山湖镇相关负责人表示，淀山湖镇正聚焦生命科学前沿技术领域，加快构建科创湖区新格 局。 湖区生命健康科学家大会由此而生。本次会议上，多位顶尖专家带来前沿学术研究报告：欧洲科学院院 士时玉舫教授系统阐述了炎症微环境与组织再生修复的关系；复旦大学王守岩教授展望了脑机接口从前 沿探索到未来产业的广阔前景；吴飞珍教授和应天雷教授分别展示了人工智能在新药筛选和新型抗体药 物研发中的颠覆性应用；器官移植专家陈忠华教授则聚焦于异种移植的生 ...

Core Viewpoint - The research highlights the role of RNA-binding protein RRP1 in regulating inflammation through its interaction with RNA, specifically in the context of one-carbon metabolism, providing new therapeutic targets for diseases like rheumatoid arthritis [3][10]. Group 1: Role of RBP in Inflammation - RNA-binding proteins (RBP) are crucial in the initiation and resolution of inflammation, and understanding their interaction with RNA and metabolism may offer new targets for controlling inflammation [5]. - RBP's interaction with RNA is dynamic and essential for maintaining cellular homeostasis, with dysregulation potentially leading to disease [3]. Group 2: Research Findings - The study published by the team led by Academician Cao Xuetao identified RRP1 as a suppressor of macrophage inflammation by regulating thymidylate synthase (Tyms) mRNA, affecting its transport and translation efficiency [3][10]. - RRP1 was found to inhibit one-carbon metabolism, thereby suppressing inflammatory responses in macrophages, which could provide a new strategy for treating autoimmune diseases [10]. Group 3: Mechanistic Insights - Mechanistically, RRP1 binds to the Tyms transcript and post-transcriptionally reduces TYMS protein levels, leading to the inhibition of folate metabolism and one-carbon metabolism-driven inflammation [7][10]. - Myeloid-specific RRP1-deficient mice exhibited severe experimental arthritis, with increased pro-inflammatory cytokines and immune damage, indicating the importance of RRP1 in inflammation regulation [8]. Group 4: Clinical Relevance - In rheumatoid arthritis patients, the expression of RRP1 in peripheral blood mononuclear cells was negatively correlated with TYMS expression and serum IL-1β levels, suggesting a potential biomarker role for RRP1 in inflammatory diseases [8].

Core Viewpoint - The article highlights significant research published in the journal Cell, with a focus on groundbreaking studies from Chinese scholars in various fields, including Alzheimer's disease treatment, cartilage regeneration, and innovative RNA-protein interaction technologies [2]. Group 1: Alzheimer's Disease Research - A study by researchers from Gladstone Institutes and UCSF identified two FDA-approved cancer drugs, letrozole and irinotecan, that can reverse gene expression changes associated with Alzheimer's disease, significantly improving memory and reducing pathological features in a mouse model [4][7]. Group 2: Cartilage Regeneration - Research from Tongji University and Hainan Medical University discovered Procr+ chondroprogenitors that are sensitive to mechanical stimuli, crucial for maintaining cartilage homeostasis and promoting regeneration after joint injury, indicating potential for treating knee diseases like osteoarthritis [9][12]. Group 3: Prime Editing for Neurological Disorders - The Broad Institute's study demonstrated the use of prime editing technology in mice to correct common ATP1A3 gene mutations associated with alternating hemiplegia of childhood, leading to significant improvements in clinical symptoms and lifespan [14][17]. Group 4: RNA-Protein Interaction Technology - A new RNA-binding protein identification technique called SPIDR was developed, allowing for the analysis of multiple RNA-binding proteins' binding sites, which could enhance understanding of RNA biology and mechanisms of translational suppression under cell stress [19][21]. Group 5: Post-Stroke Brain Inflammation - Research from Johns Hopkins University revealed that the mast cell receptor Mrgprb2/MRGPRX2 mediates brain inflammation after a stroke, and inhibiting this receptor can reduce inflammation and improve neurological outcomes in mice [23][25]. Group 6: Aging Proteome Atlas - A comprehensive study by the Chinese Academy of Sciences constructed a proteome aging atlas across a 50-year lifespan, identifying aging trajectories and key proteins like GAS6 that drive vascular and systemic aging [27].

Core Viewpoint - The article discusses the role of mast cell receptor Mrgprb2 in mediating post-stroke brain inflammation, highlighting its potential as a therapeutic target to improve neurological outcomes after stroke [4][10]. Group 1: Research Findings - The study published in Cell reveals that the mast cell-specific receptor Mrgprb2 mediates brain inflammation after stroke through a dural-brain signaling axis [5][10]. - Inhibition of Mrgprb2 reduces post-stroke brain inflammation in mice, leading to improved neurological function and increased survival rates [5][10]. - Mrgprb2 acts as a key "gatekeeper" for the migration of immune cells from the skull bone marrow to the brain [13][14]. Group 2: Mechanisms of Action - Mrgprb2 activation leads to degranulation of mast cells in the meninges, releasing immune mediators that recruit neutrophils to the dura mater and promote their migration into brain tissue [8][14]. - The study indicates that mast cell proteases can cleave semaphorin proteins, facilitating neutrophil infiltration into the brain [14]. Group 3: Related Research - Another study published on the same day in Cell by Jonathan Kipnis's team discusses how mast cells regulate the brain-dura interface and cerebrospinal fluid (CSF) dynamics [15][19]. - The findings suggest that mast cells are crucial regulators of CSF flow and meningeal immunity, with potential implications for enhancing CNS clearance and defense mechanisms against infections [19].

Core Viewpoint - The article emphasizes the potential health benefits of mango consumption, particularly its role in improving insulin sensitivity and metabolic health in overweight or obese individuals with chronic low-grade inflammation [3][10]. Summary by Sections Blood Sugar Regulation - Blood sugar is a crucial health indicator, with normal fasting levels between 3.9-6.1 mmol/L and postprandial levels not exceeding 7.8 mmol/L. Dietary choices significantly impact blood sugar control, where a balanced diet stabilizes blood sugar, while poor eating habits can lead to spikes [3]. Mango's Nutritional Benefits - Mango is highlighted for its high dietary fiber content and various vitamins and minerals. Previous studies have shown that moderate mango intake may positively affect blood sugar regulation and inflammation [3][10]. Clinical Study Overview - A recent randomized, placebo-controlled trial involved 48 participants with specific metabolic characteristics, including a BMI of ≥25 kg/m² and fasting blood glucose levels between 100-126 mg/dL. Participants were divided into two groups: one consuming fresh mango (approximately 230 grams daily) and the other receiving a mango-flavored placebo drink [6][7]. Study Findings - After four weeks, the study assessed blood sugar control using the oral glucose tolerance test (OGTT) and measured various metabolic parameters. Results indicated that regular mango consumption significantly improved insulin sensitivity, evidenced by decreased fasting insulin levels and improved HOMA-IR index [7][9]. Inflammation Markers - No significant statistical differences were found in inflammation markers between the mango and control groups, suggesting that mango's effect on insulin sensitivity may not directly involve inflammation pathways. The study primarily focused on IL-6, TNF-α, and hs-CRP, leaving out other relevant inflammatory markers [8]. Nrf-2 Gene Expression - An interesting finding was the approximately twofold increase in Nrf-2 gene expression in the mango group, although not statistically significant. Nrf-2 is crucial for activating antioxidant genes, which may enhance cellular antioxidant defenses and alleviate oxidative stress, potentially explaining the improvement in insulin sensitivity [9][10]. Conclusion and Future Research - The study concludes that mango, rich in active polyphenols and antioxidants, may serve as a dietary intervention for improving insulin resistance. Further research is recommended to explore the mechanisms and broader health benefits of mango consumption [10][11].

十年里，生命科学领域共有14位未来科学大奖获奖者。其中， 邵峰、柴继杰、周俭民、李文辉4位获奖者的主要科学发现是 在北生所完成的。为什么北生所会出现这么多顶尖科学家、涌 现这么多原始创新成果？经济观察报曾分别专访这4位获奖 者，他们讲述了他们所知道的北生所。 作者：张铃 封图：图虫创意 北生所筹建于2003年，作为"中国科技体制改革试验田"，这里无行政级别，无事业编制，科学家 能自主确定研究方向，也可以不为经费发愁。此后几年，一批优秀的年轻学者闻声而来，其中就包 括2004年加入的柴继杰和周俭民（后分别于2010年和2012年离开北生所）、2005年加入的邵峰、 2007年加入的李文辉。 为什么北生所会出现这么多顶尖科学家、涌现这么多原始创新成果？ 经济观察报曾分别专访这4位 获奖者，他们讲述了他们所知道的北生所。 自主革自己的命 二十年前，决定回国并加入北生所时，邵峰并没有多数人的纠结。他设想了最坏的局面：给我三年 时间，如果做不出东西来，我就认了，大不了卷铺盖走人。 2025年7月，未来科学大奖举办十周年特别活动。这个由杨振宁发起的、被认为是中国本土最重要 的科学奖项，走到了第十个年头。 十年里，生命科学 ...

撰文丨王聪 编辑丨王多鱼 排版丨水成文 炎症 对于维持体内平衡以及保护组织和器官的完整性至关重要。然而，过度的炎症反应可能会导致严重的组织损伤。炎症反应的强度、持续时间和影响必须根据 炎症诱因的存在以及病理结果的程度进行调节。我们对于炎症的保护作用和病理作用的诸多认识，都与炎症反应如何影响器官功能有关。相比之下，我们对于特 定组织的状态如何影响炎症反应，仍知之甚少。 维持稳定的 pH 值 是组织内环境稳定的普遍特征。不同的组织和器官维持着不同的间质 pH 值环境，这些环境在炎症期间常常会受到干扰。例如，血液的 pH 值 被严格控制在 7.35-7.45 之间，而脓毒症中的严重酸中毒与不良预后相关；淋巴结副皮质区的 pH 值在 6.3-7.1 之间，在感染期间会变得更酸； 实体瘤通常表现 出酸性环境。这些都表明了 组织微环境偏离正常生理 pH 值 的酸化与炎症密切相关。 2025 年 7 月 17 日，波士顿儿童医院/哈佛大学医学院 周旭 教授团队与耶鲁大学 R uslan Medzhitov 教授 团队合作 （博士后 吴中洋 为论文第一作者） ，在国 际顶尖学术期刊 Cell 上发表了题为： Regulati ...

2025 年 7 月 15 日，西湖大学 何丹阳 课题组与 徐和平 课题组合作 （ 王琰 为第一作者 ） ， 在 Immunity 期刊 发表题为： Cognate interaction-dependent pathogenicity of meningeal B cells drives neuroinflammation relapse 的研究论文。 该研究表明， 脑膜内自身反应性 B 细胞与抗原特异性 T 细胞相互作用，促进神经系统自身免疫性炎症的 复发 ，首次证实了中枢神经系统局部 B 细胞是神经炎症复发的关键开关，也为多发性硬化症 （MS） 的"中枢炎症驱动"理论提供了直接证据。 撰文丨王聪 编辑丨王多鱼 排版丨水成文 B 细胞 是中枢神经系统 （CNS） 自身免疫疾病 的核心驱动因素，例如 多发性硬化症 （ Multiple Sclerosis， MS） 。尽管 脑膜 通常维持着严格不发生自身免疫反应的 B 细胞谱系，但这种局部免疫耐受 的破坏如何导致病理变化，目前仍不清楚。 在这项最新研究中，研究团队证明了位于大脑边缘的自身反应性 B 细胞通过直接与致脑炎性 T 细胞结合而 加速了神经炎症。 ...

编辑丨王多鱼 排版丨水成文 有 结核分枝杆菌 （ Mycobacterium tuberculosis ） 感染史的患者，往往会出现不可逆且进行性的 肺损 伤 ，但其潜在机制尚不完全清楚。 2025 年 7 月 14 日，中国科学院动物研究所 刘光慧 研究员联合天津大学海河医院 陈怀永 教授、首都医 科大学宣武医院 王思 教授及中国科学院动物研究所 曲静 研究员团队，在 Nature Microbiology 期刊 发表了 题为： A single-cell transcriptomic atlas reveals senescence and inflammation in the post-tuberculosis human lung 的研究论文。 该研究构建了首个 结核杆菌 感染后肺组织的高精度细胞分子网络，并运用多维度分析策略系统阐明： 细胞 衰老与炎症是结核感染后肺损伤的关键病理特征，而内皮细胞衰老及血管炎症则是这一过程中的核心事件 。并进一步首次阐明了 FOXO3 表达下调协同凝血酶-炎症信号通路驱动结核杆菌感染导致的慢性肺损伤的 分子机制，为该疾病提供了潜在干预靶点。 在这项最新研究中，研究团 ...

撰文丨王聪 编辑丨王多鱼 排版丨水成文 炎症性衰老 （ inflammaging ） ，即与年龄相关的慢性炎症增加，被认为是 衰老 的一个标志。然而，目前对于基于循环细胞因子来衡量炎症性衰老还没有达成 一致的方法。 近日 ，加拿大 舍布鲁克大学和美国哥伦比亚大学的研究人员合作，在 Nature 子刊 Nature Aging 上发表了题为 ： Nonuniversality of inflammaging across human populations 的研究论文。 该研究通过比较工业化人群 （来自 意大利和新加坡的人群 ） 和非工业化人群 （来自 玻利维亚和马来西亚的原住民 ） ，发现 炎症性衰老 （ inflammaging ） 在不同群体中并不具有普遍性， 生活方式工业化程度较低的人群可能不会经历炎症性衰老。因此， 炎症性衰老可能只是工业化生活方式的副产物，因此在全球不 同人群中存在着显著差异。 短期炎症对于治愈感染至关重要，但长期炎症暴露 （炎症性衰老） 已知会增加生物学衰老和出现年龄相关性疾病的风险。不过，之前并不确定炎症性衰老对所有 人群的影响是否一致。 在这项新研究中，研究团队评估了在意大利的 ...