以下文章来源于肥胖世界ObesityWorld ，作者肥胖世界 肥胖世界ObesityWorld . 《肥胖世界》Obesity World - 同步传真肥胖及代谢国际新学术进展，为医学减重临床、教研人员搭建一座与国际接轨的桥梁，「每医健」旗下内容平台。 你是否有这样的困惑：步入30或40岁后，腹部赘肉变得异常难缠？明明饮食比年轻时更加节制，运动也更为积极，腰围却依然不断扩张…… 别急着自责缺乏毅力！《Science》杂志最新研究揭示了中年发福、腹部脂肪难以消除的真相：我们内脏脂肪中存在一种特殊细胞，它们会随 着衰老过程变得异常活跃，大量促进脂肪生成。所以，中年腹部减肥困难，或许真不完全是你的错！ 中年发福的真相：不只是脂肪细胞变大那么简单 先抛出一个灵魂拷问：你的身材是如何逐渐"圆润"起来的？虽然炸鸡啤酒确实"功不可没"，但从生物学角度看，体重增加主要通过两种机制实 现： 脂肪细胞数量增加 单个脂肪细胞体积膨胀 究竟是谁在推动这场中年脂肪生成狂欢？借助单细胞测序技术，科学家们发现了惊人真相：随着衰老，无论小鼠还是人类，内脏脂肪组织中的 脂肪祖细胞(APCs)群体结构发生了显著变化。其中，一种名为CP-A(中 ...

Core Viewpoint - The article discusses the biological mechanisms behind weight gain in middle age, particularly focusing on the role of a specific type of fat precursor cell (CP-A) that becomes more active with aging, leading to increased visceral fat accumulation [7][24]. Group 1: Mechanisms of Weight Gain - Traditional views suggest that fat cell numbers remain constant after adulthood, with weight gain primarily due to existing fat cells enlarging. However, recent studies indicate that new fat cells are generated in significant numbers during middle age [9][10]. - A specific type of fat precursor cell, known as CP-A, becomes predominant in visceral fat tissue as individuals age, contributing to increased fat generation [12][15]. Group 2: Characteristics of CP-A Cells - CP-A cells exhibit enhanced proliferation and differentiation capabilities compared to younger fat precursor cells, leading to a higher rate of fat cell production [17][19]. - In middle-aged mice, CP-A cells account for approximately 34.23% of the visceral white fat tissue, indicating a significant shift in fat cell composition with aging [15]. Group 3: Potential Interventions - The LIFR signaling pathway has been identified as a potential target for controlling the proliferation and fat-generating activity of CP-A cells. Inhibition of LIFR significantly reduces fat generation in CP-A cells while having minimal effect on younger fat precursor cells [20][22]. - Targeting LIFR could provide a new strategy to combat stubborn fat accumulation in middle-aged individuals, offering a scientific solution to a common issue [25].