华谊信资本 | SPAC | De-SPAC | SPAC IPO | 资本市场 | 纳斯达克 | PIPE融资 2025年开年至今，全美SPAC IPO市场表现强劲：62家SPAC完成上市（超2024全年57 家，同比增8.8%），募资额更猛——108亿美元，是去年同期的近6 倍。单家平均募资1.8亿、中位数冲至2亿，对比去年同期的数据，几乎是"量级跃升"。更关键的是，资本动作不止于上市：23家已敲定并购，27家正推进合 并。 本文华谊信资本统计了美股De-SPAC的相关数据，并结合其最新数据和财务披露要求做了详细分析，希望对拟De-SPAC形式登陆美股市场的企业有所帮助。 一、2025年上半年美股De-SPAC上市情况 2025 年上半年，23家SPAC完成并购交易（总价值约225亿美元），截至6月底，另有 21家正寻求新的并购对象。 今年第一季度，有10家SPAC完成并购交易；第二季度有13家SPAC完成并购交易。这也从侧面反映了美股SPAC市场不仅只注重数量，更追求质量。 这也从侧面反映了美股SPAC市场并购节奏持续提速，全链条活跃度显著回升——从IPO募资的放量，到并购交易的季度环比增长（Q2较Q1 ...

Talphera (TLPH) Q1 2025 Earnings Call May 14, 2025 04:30 PM ET Company Participants Raffi Asadorian - CFOVincent Angotti - CEOShakil Aslam - Chief Medical Officer Conference Call Participants None - Analyst Operator Welcome to the TULFERA First Quarter twenty twenty five Financial Results Conference Call. This call is being webcast live via the Events page of the Investors section of TULFERA's website at www.tolpera.com. You may listen to a replay of this webcast by going to the Investors section of TULFERA ...

Financial Data and Key Metrics Changes - The cash operating expenses for Q1 2025 totaled $2.9 million, a decrease from $4.2 million in Q1 2024, indicating a reduction in personnel and general administrative expenses [17][18] - The company has adjusted its 2025 expected cash operating expense guidance to a range of $17 million to $19 million [17] Business Line Data and Key Metrics Changes - The nephro CRRT trial has seen a reduction in study size from 166 patients to 70 patients, which is expected to shorten the study completion time [4][5] - The company has added three new clinical study sites that are actively screening patients, with five more expected by mid-year [6][12] Market Data and Key Metrics Changes - There is an ongoing inquiry from healthcare providers regarding the availability of Nefamostat due to shortages of citrate and potential supply chain issues with heparin [7] Company Strategy and Development Direction - The company is focused on completing the nephro study by the end of 2025 and believes that the new site engagement will significantly contribute to study enrollment [11][15] - The company is exploring a compassionate use IDE for Nefamostat, responding to requests from institutions for patients who do not respond well to current anticoagulants [13] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the low clinical, regulatory, and commercial risks associated with the nephro program, citing a strong track record of nafamostat's efficacy and safety [15] - The company anticipates that the expanded enrollment criteria will lead to increased activity at both legacy and new sites, although immediate results from legacy sites have not yet materialized [24][30] Other Important Information - The company completed a PIPE financing structured in three tranches, with the first tranche received and the remaining tranches contingent on patient enrollment milestones [19] Q&A Session Summary Question: Has the broader enrollment criteria started to translate into increased enrollment? - Management noted that while there has been increased activity at the sites due to broader criteria, it has not yet translated into new patients from legacy sites [24][25] Question: What are the challenges faced by legacy sites in enrolling patients? - The legacy sites are primarily dependent on surgical ICUs or cardiothoracic ICUs, which limits their patient pool despite the expanded criteria [29]