Core Insights - Eli Lilly and Company reported a strong financial performance in Q1 2025, with a 45% year-over-year revenue growth driven by robust sales of Mounjaro and Zepbound [2][3][7] - The company is investing in manufacturing to meet global demand for its new medicines, including plans to build four new facilities [2][19] - The pipeline continues to show promise with recent product approvals in oncology and immunology, and positive Phase 3 trial results for orforglipron in diabetes and obesity [2][19] Financial Results - Total revenue for Q1 2025 was $12.73 billion, a 45% increase from $8.77 billion in Q1 2024, primarily due to a 53% increase in volume [3][7] - Net income for Q1 2025 was $2.76 billion, up 23% from $2.24 billion in Q1 2024, with reported earnings per share (EPS) increasing to $3.06 from $2.48 [11][36] - Non-GAAP net income was $3.00 billion, a 29% increase from $2.34 billion in Q1 2024, with non-GAAP EPS rising to $3.34 from $2.58 [13][36] Revenue Breakdown - U.S. revenue increased by 49% to $8.49 billion, driven by a 57% increase in volume, mainly from Zepbound and Mounjaro [4][7] - Revenue outside the U.S. rose 38% to $4.24 billion, with a 46% increase in volume, primarily from Mounjaro and Jardiance [5][7] - Mounjaro revenue surged 113% to $3.84 billion, while Zepbound revenue reached $2.31 billion, up from $517.4 million in Q1 2024 [16][17] Cost and Margin Analysis - Gross margin increased 48% to $10.50 billion, with a gross margin percentage of 82.5%, up 1.6 percentage points from the previous year [6][11] - Research and development expenses rose 8% to $2.73 billion, representing 21.5% of revenue, while marketing, selling, and administrative expenses increased 26% to $2.47 billion [8][11] Guidance and Future Outlook - The company reaffirmed its 2025 revenue guidance of $58.0 billion to $61.0 billion, with an expected performance margin of 40.5% to 42.5% on a reported basis [20][22] - The effective tax rate for 2025 is projected to be around 17%, up from approximately 16% [21][22] - EPS guidance for 2025 has been adjusted to a range of $20.17 to $21.67 on a reported basis, reflecting the impact of acquired IPR&D charges [22][23]

Merck (MRK) reported its first-quarter 2025 results last week, beating estimates for both earnings and sales. Adjusted earnings of $2.22 per share rose 12% year over year, excluding foreign exchange impact. Revenues of $15.53 billion rose 1% year over year as higher sales of blockbuster cancer drug, Keytruda, new products like Welireg, Winrevair and Capvaxive and strong performance of the Animal Health segment were partially offset by lower sales of the HPV vaccine Gardasil in China. Keytruda, the biggest p ...