Core Insights - Ribo Life Science has been invited to present at the RNA Leaders Europe Conference, highlighting its advancements in ex-hepatic delivery technologies [1] - The company has achieved significant success with its RiboGalSTAR™ platform, which targets liver-specific genes and has secured collaborations and licensing deals valued over USD 6 billion [1] - Ribo is now focusing on expanding its proprietary RiboPepSTAR™ delivery technology to enable targeted siRNA delivery to organs beyond the liver, including the kidneys, heart, adipose tissue, muscle, and central nervous system [1] Group 1 - Ribo Life Science will present data on ex-hepatic delivery at the RNA Leaders Europe Conference in Vienna on March 19, 2026 [1] - The company has seven clinical programs and two major global collaborations, indicating a strong pipeline and strategic partnerships [1] - The RiboPepSTAR™ platform has demonstrated effective kidney delivery with preclinical data showing specific uptake and mRNA knockdown across species [1] Group 2 - Ribo is developing additional targeted drug candidates to extend therapeutic applications to various diseases beyond liver conditions [1] - The company aims to advance its ex-liver product offerings to provide innovative siRNA therapeutics to patients globally [1]

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The Stock Exchange of Hong Kong Limited and the Securities and Futures Commission take no responsibility for the contents of this Application Proof, make no representation as to its accuracy or completeness and expressly disclaim any liability whatsoever for any loss howsoever arising from or in reliance upon the whole or any part of the contents of this Application Proof. Application Proof of Suzhou Ribo Life Science Co., Ltd. 蘇州瑞博生物技術股份有限公司 (the "Company") (A joint stock company incorporated in the People ...

Core Viewpoint - Alnylam Pharmaceuticals reported strong second-quarter earnings and raised its 2025 sales guidance, indicating positive momentum in its product launches and overall financial performance [1][3]. Financial Performance - The company reported adjusted earnings of 32 cents for Q2 2025, a decrease from 56 cents year-over-year, but significantly better than analysts' expectations of a loss of 79 cents [1]. - Quarterly sales reached $773.69 million, reflecting a 17% year-over-year increase and surpassing the consensus estimate of $638.55 million [1]. Product Revenue - Global net product revenues for Amvuttra and Onpattro were $492 million and $53 million, respectively, while Givlaari and Oxlumo generated $81 million and $47 million in revenue for the same quarter [2]. - The launch of Amvuttra for ATTR-CM has been particularly successful, with approximately 1,400 patients treated by June 30, 2025, contributing to an estimated $150 million increase in revenue [4]. Guidance and Analyst Outlook - Alnylam raised its fiscal 2025 sales guidance from $2.7 billion-$3 billion to $3.3 billion-$3.55 billion, exceeding the consensus of $2.89 billion [3]. - Analysts from Chardan Research and William Blair expressed positive outlooks, with Chardan highlighting the strong start of Amvuttra's launch [3][6]. Analyst Ratings and Price Forecasts - Various analysts have upgraded their price forecasts for Alnylam, with Chardan raising its target from $325 to $400, and UBS increasing its forecast from $403 to $550 [5][8]. - Morgan Stanley maintained an Equal-Weight rating while increasing its price forecast from $312 to $405, and Piper Sandler raised its target from $304 to $449 [7].