1月9日，苏州瑞博生物技术股份有限公司（以下简称：瑞博生物；股票代码：06938.HK）正式于香港 联合交易所挂牌上市。在近年来港股生物科技板块持续深化发展、监管环境不断优化的背景下，具备扎 实技术与清晰管线的创新药企愈发受到投资者关注，瑞博生物的上市为此再添例证。 瑞博生物此次全球发售共计3161.04万股，发行价为每股57.97港元，首日开盘报75港元，较发行价上涨 29.38%。本次招股公开发售部分获超100倍认购，国际发售部分达到16.7倍认购，募集资金总额超18亿 港元。 作为中国小核酸技术与制药领域的主要开拓者，瑞博生物此次上市吸引了多家国内外知名投资机构的参 与，包括华夏基金、大成基金、大成国际及泰康人寿等国内头部投资机构，以及Arc Avenue， Himension Fund、Erik Selin Fastigheter AB等国际资本，体现了全球投资者对小核酸赛道价值及公司实 力的高度认可。 行业前景广阔，管线瞄准巨大未满足临床需求 瑞博生物所专注的领域，正对应着广阔的市场前景与迫切的未满足临床需求。全球小核酸药物市场正处 于高速增长通道，根据弗若斯特沙利文报告，全球小核酸药物市场已从20 ...

在全球医药创新快速迈向"核酸时代"的背景下，小核酸药物凭借其能够从基因源头精准干预疾病机制的优势，正逐步 成为继小分子、抗体药之后又一颠覆性治疗范式，引领着新一轮生物医药的创新浪潮。 然而，真正具备小核酸药物全链条自主研发能力的企业在全球范围内仍寥寥无几。瑞博生物作为国内该领域的先行者 与平台型公司，已构建覆盖从靶点发现到临床开发的全流程技术体系，不仅实现了关键技术与核心平台的自主可控， 更展现出参与国际竞争、定义治疗新标准的潜力。 那么，瑞博生物此番上市有哪些看点？ 图表一：瑞博生物招股书 临近年末，中国创新药行业再迎重磅玩家登陆港交所。 中国小核酸领域的领军企业瑞博生物，于今日正式启动公开招股。公司发行价定为每股57.97港元，每手200股，入场 费11710.93港元，预计将于2026年1月9日在港交所主板挂牌上市。此次发行已吸引Arc Avenue、Bright Stone、华夏基 金、大成国际及大成基金、泰康人寿等多家知名机构作为基石投资者参与认购，市场关注度持续升温。 | c球發售的發售股份數目 | | : 27.487.400股H股(視乎發售量調整權 | | --- | --- | --- | ...

RBD4059为全球首款且临床开发进展最快的抗血栓siRNA药物。 本文为IPO早知道原创 作者｜罗宾 瑞博生物目前拥有 6 款自研管线处于临床试验阶段，涉及 7 种适应症，其中 4 款处于 2 期临床试验 中，一款已进入 III 期临床试验。公司还有 20 个计划推进到临床开发阶段的临床前项目。 来源：公司招股书 核心产品 RBD4059 （靶向 FXI 的 siRNA ）为全球首款、也是临床开发进展最快的用于治疗血栓性 疾病的 siRNA 药物 ，通过选择性抑制 FXI ， RBD4059 可在不显著增加出血风险（传统抗凝剂的常 见局限性）的情况下降低血栓形成的风险，同时以低频率的给药产生持久的疗效，提高患者的依从 性。 同时，公司还在推进两款关键产品 RBD5044 及 RBD1016 。 RBD5044 是全球第二个进入临床开发 的靶向 APOC3 的 siRNA 。 APOC3 是一种在脂质代谢中起关键作用的蛋白质。而 RBD1016 凭借 其对 HBsAg 的强效和持久作用，是未来实现 CHB 功能性治愈的联合方法的重要支柱疗法，及治疗 CHD 的领先 siRNA 候选药物。 公司经过近二十年的专 ...

Core Viewpoint - Suzhou Ribo BioTechnology Co., Ltd. has submitted its A1 listing application to the Hong Kong Stock Exchange, marking a significant step in its development as a pioneer in RNA interference (RNAi) technology and small nucleic acid drug commercialization [1] Group 1: Company Overview - Ribo Bio was established in 2007 and is one of the earliest pioneers in the field of RNAi technology [1] - The company has received strategic investments from several well-known institutions, including Junlian Capital and Guotou Innovation [1] Group 2: Market Potential - The global small nucleic acid drug market has grown from $2.7 billion in 2019 to $4.6 billion in 2023, with a compound annual growth rate (CAGR) of 14.3%, and is expected to reach $46.7 billion by 2033 [2] - siRNA drugs are seen as a disruptive innovation in the pharmaceutical industry, with clinical success rates improving from below 10% for traditional drugs to over 60% for siRNA [2] Group 3: Product Pipeline - Ribo Bio currently has six self-developed siRNA drugs in clinical trials, with four in Phase II trials and over 20 preclinical assets in development [4] - The key product RBD4059 is the first siRNA drug for thrombotic diseases and is progressing rapidly in clinical trials [6] - RBD5044 targets high triglycerides and is the second siRNA drug targeting APOC3 to enter clinical development [7] - RBD7022 is a promising candidate for treating high cholesterol, showing comparable LDL-C reduction to the approved drug Inclisiran [8] - RBD1016 is a key candidate for chronic hepatitis B treatment, showing good safety and efficacy in early trials [9] Group 4: Technological Advancements - Ribo Bio has developed the RiboGalSTAR™ liver-targeting delivery platform, which has shown strong efficacy and safety in clinical studies [12] - The company has established a comprehensive R&D network with nearly 300 researchers and has a production line compliant with EU GMP standards [11] Group 5: Strategic Collaborations - Ribo Bio has entered a significant collaboration with Boehringer Ingelheim, valued at over $2 billion, marking a notable recognition of its RNAi technology platform [13] - The company aims to leverage its innovative capabilities and global partnerships to enhance its position in the small nucleic acid drug market [13]