Core Viewpoint - Wantaibio, once thriving with its domestic HPV vaccine, is now facing significant performance decline, reporting its first half-year loss since its IPO in 2020, with a net loss of 144 million yuan in the first half of 2025, a stark contrast to a profit of 264 million yuan in the same period last year [2][3] Financial Performance - In the first half of 2025, Wantaibio's revenue was only 844 million yuan, a year-on-year decrease of 38.25% [3] - The net profit attributable to shareholders was -144 million yuan, a decline of 155.30% year-on-year [3] - Excluding non-recurring gains and losses, the net profit dropped to -243 million yuan, a staggering decline of 481.93% [3] - Basic earnings per share were -0.11 yuan, down 152.38% year-on-year [3] - In Q2 2025, total revenue was 443 million yuan, a decrease of 27.81% year-on-year, with a net profit of -91.26 million yuan, down 167.72% [3] Market Dynamics - The significant decline in Wantaibio's performance is attributed to both external environmental changes and internal factors, with external changes being more pronounced [5] - Competition from international giants like Merck has intensified, impacting market share due to their brand influence and established marketing systems [5] - The implementation of centralized procurement policies has led to a decrease in product prices, significantly affecting revenue and profit [5] - Wantaibio's business model heavily relies on its bivalent HPV vaccine, making it vulnerable to market fluctuations and competitive pressures [5][6] HPV Vaccine Market Trends - The overall competition in China's HPV vaccine market is becoming increasingly fierce, with rising public health awareness leading to growing demand for HPV vaccines [6] - The bivalent HPV vaccine, once a market leader, is now facing challenges from the expanding supply and age range of the nine-valent vaccine, which offers broader protection [6][7] - The price war has intensified, with prices for the bivalent vaccine dropping significantly, impacting revenue [8] - Wantaibio's bivalent vaccine revenue contribution has plummeted from over 70% in 2021-2022 to less than 30% in 2024, with a 67.3% year-on-year decline in the first half of 2025 [7][9] Future Outlook - The future competition in the nine-valent HPV vaccine market will focus on pricing, effectiveness, production capacity, and sales channel optimization [10] - Wantaibio, despite being the first to report a nine-valent HPV vaccine, faces challenges from competitors and must improve in pricing, capacity, and sales channels to maintain a competitive edge [10] - The company's ability to commercialize the nine-valent vaccine and diversify its product matrix will be crucial for reversing its current performance decline [10]

Core Insights - Wantaibio (603392) reported a significant decline in revenue and net profit for 2024, with revenue at 2.245 billion yuan, down 59.25% year-on-year, and net profit at 106 million yuan, down 91.49% year-on-year, marking the lowest figures since the company went public five years ago [1][2] Revenue Breakdown - The company's revenue is primarily derived from two sectors: in vitro diagnostics and vaccines. The vaccine segment has seen a drastic decline due to market adjustments, government procurement policies, and the expansion of the target population for the nine-valent HPV vaccine [2][3] - In 2024, the vaccine segment generated revenue of 606 million yuan, a decrease of 84.69% year-on-year, with a gross margin reduction of 21.17% [2] - Vaccine production volume in 2024 was 10.5932 million doses, down 64.66% year-on-year, while sales volume was 9.0492 million doses, down 42.40% year-on-year [2] Historical Performance - Wantaibio's revenue from 2020 to 2023 was as follows: 2.354 billion yuan, 5.750 billion yuan, 11.19 billion yuan, and 5.511 billion yuan, respectively. Net profits for the same years were 1.118 billion yuan, 2.021 billion yuan, 4.736 billion yuan, and 1.248 billion yuan [2][3] - The vaccine segment was a major revenue driver, contributing significantly to the company's peak performance in 2022, where total revenue reached 11.185 billion yuan and net profit was 4.736 billion yuan, with vaccines accounting for 75.93% of total revenue [3] Competitive Landscape - The nine-valent HPV vaccine faces intense competition, with market demand slowing and other companies advancing their research rapidly. The domestic market for HPV vaccines is experiencing price wars due to government procurement policies [4][5] - Wantaibio's nine-valent HPV vaccine application was accepted on August 26, 2024, making it the first domestic nine-valent HPV vaccine to apply for market approval [4][6] - Other companies, such as Watson Bio and others, are also developing nine-valent HPV vaccines, with some expected to submit their applications for approval in the coming years, posing a potential threat to Wantaibio's market position [5][6]