Core Viewpoint - The article emphasizes the critical role of managing prediabetes and obesity in preventing the progression to diabetes and cardiovascular diseases, highlighting the effectiveness of the drug Semaglutide (weight loss version) in improving health outcomes for overweight and prediabetic patients [5][6][20]. Group 1: Prediabetes and Health Risks - Prediabetes is a significant health warning signal, with 5%-10% of patients progressing to diabetes annually, and it is associated with increased cardiovascular risks [5][8]. - Meta-analysis shows that prediabetic patients have higher all-cause mortality and cardiovascular event rates compared to those with normal blood sugar levels [8][26]. Group 2: Obesity as a Risk Factor - There is a strong positive correlation between obesity and the risk of prediabetes, with risk increasing significantly as BMI rises: 25% increase for BMI 25.0-29.9 kg/m² and 184% for BMI ≥40 kg/m² [9][11]. - The 2023 Expert Consensus on Diabetes Prediabetes Intervention emphasizes weight management as a core strategy to prevent the progression of prediabetes [9][11]. Group 3: Semaglutide's Impact - The SELECT study demonstrated that Semaglutide (weight loss version) significantly reduces the risk of major cardiovascular adverse events (MACE) by 20% compared to placebo [17][18]. - The drug also shows remarkable effects on blood sugar control, with nearly 70% of patients achieving normal blood sugar levels, far exceeding the placebo group [18][20]. Group 4: Future Outlook - There is optimism that more prediabetic patients will receive early intervention, leading to improved long-term outcomes for overweight and obese individuals [21][22]. - The treatment of metabolic diseases is expected to enter a new era of precision and individualization [22].

整理 | GLP1减重宝典内容团队 5月11日是"世界防治肥胖日"。近30年来，我国肥胖与超重人群迅速增长，已成为威胁居民健康的重大公共卫生问题。 肥胖不仅是独立 的疾病，也是多种慢性病的重要诱因 ，若不能有效控制，将持续推高相关慢病的发生率。 肥胖问题早已突破个人层面，演变为全球范围的代谢性挑战。世界卫生组织数据显示，2020年全球超重或肥胖人口已超20亿，预计到 2035年将增至33亿。截至2021年，中国25岁以上人群中，超重和肥胖者多达4.02亿，位居全球首位。根据预测， 到2030年，我国成人 和儿童的超重与肥胖率将分别达到70.5%和31.8%，肥胖已成为我国第六大致死致残危险因素。 为应对这一挑战， 国家卫健委于2024年6月联合16个部门共同启动"体重管理年"， 旨在提升公众健康意识，普及科学体重管理理念，从 政策层面强化控肥行动，这也是"健康中国"战略的重要组成部分。 在全球范围内，防控肥胖的措施也正持续推进。《柳叶刀·糖尿病与内分泌学》近日发布一份重要报告，建议在诊断肥胖时将体脂指标 （如腰围、腰臀比、腰高比或体脂含量）与体质指数（BMI）结合使用，以降低误判风险。这一新型诊断方法不仅提升 ...