1940-1970年代，中国表观遗传学处于探索奠基阶段。1942年，英国生物学家Conrad Waddington首次提 出"表观遗传学"概念，但中国受苏联李森科主义影响，遗传学发展受阻。1950年代，摩尔根学派被压 制，表观遗传学研究停滞。1952年高校院系调整削弱了清华大学、浙江大学等高校的遗传学专业。1956 年"青岛会议"后遗传学短暂发展，但"文化大革命"期间研究再次受冲击。1978年中国遗传学会成立，遗 传学研究恢复发展，为表观遗传学奠定基础。 1980-1990年代，中国表观遗传学进入初步发展阶段。改革开放后，中国引进国际先进遗传学理论，表 观遗传学逐渐被引入。1980年代，DNA甲基化、组蛋白修饰等机制开始被研究。1990年代，中国科学 家参与国际研究，如1996年C. David Allis发现组蛋白乙酰转移酶。1990年代，中国启动"863计划""973 计划"等，支持遗传学与表观遗传学研究。 内容概况：近年来，中国表观遗传学行业取得了显著进展，逐渐成为生命科学领域的研究热点。2024 年，中国表观遗传学行业市场规模约为43.96亿元，同比增长62.27%。这不仅反映了技术的不断进步， 也体 ...

Core Viewpoint - Shanxi Agricultural University has announced multiple government procurement intentions for laboratory instruments, with a total budget of 0.98 billion yuan, indicating a significant investment in research and development capabilities [2][3]. Summary by Sections Procurement Intentions - The university plans to procure four types of laboratory instruments, including ion exchange chromatography, terahertz spectroscopy detection systems, atomic force microscopes for engineering materials, flow cytometers, and real-time fluorescent quantitative PCR instruments, with the expected procurement period from April to August 2025 [3][4]. Instrument Descriptions - **Terahertz Spectroscopy Detection System**: An advanced analytical technology based on terahertz electromagnetic radiation, applicable in materials science, biomedical fields, safety inspections, drug testing, and agricultural quality control, with a frequency range of 0.1 THz to 10 THz [4]. - **Ion Exchange Chromatography**: A liquid chromatography technique based on electrostatic interactions, widely used in biochemistry, pharmaceuticals, environmental analysis, and food science for the separation and purification of ionic or ionizable molecules [5]. - **Real-time Fluorescent Quantitative PCR Instrument**: A precision instrument for real-time monitoring of DNA/RNA amplification during PCR, essential in molecular biology, medical diagnostics, biotechnology, food safety, and environmental monitoring [6]. Research and Development Capacity - Shanxi Agricultural University, established in 1907, is a prominent agricultural institution with a strong focus on agricultural science, integrating multiple disciplines such as biology, environment, and materials science, aimed at promoting agricultural technology innovation and rural revitalization [8][9]. - The university hosts national and provincial key laboratories and engineering research centers, undertaking numerous significant research projects with internationally influential outcomes [9][10]. - The university's research teams focus on solving critical agricultural issues, translating laboratory results into practical applications to ensure national food security and promote sustainable development [10].

Core Viewpoint - The customs system has announced procurement intentions for 31 items of laboratory reagents and consumables, with a total budget of 102 million yuan, scheduled for procurement between June and October 2025 [1]. Group 1: Procurement Overview - The total budget for the procurement of laboratory reagents and consumables is 102 million yuan [1]. - The procurement includes high-performance liquid chromatography triple quadrupole mass spectrometers, high-efficiency liquid chromatographs, and other advanced laboratory instruments [1]. Group 2: Specific Procurement Projects - Qingdao Customs Technology Center plans to procure chemical reagents and consumables with a budget of 10 million yuan in August 2025 [3]. - Wuhan Customs Technology Center will procure various reagents and consumables for laboratory testing, with a budget of 2.68 million yuan in August 2026 [3]. - The Quanzhou Customs Comprehensive Technology Service Center intends to purchase one ultra-high-performance liquid chromatography triple quadrupole mass spectrometer for 2.6 million yuan and five high-efficiency liquid chromatographs for a total of 2.45 million yuan in June 2025 [3]. Group 3: Instrument Updates and Enhancements - The Weifang Customs Comprehensive Technology Service Center plans to update 22 laboratory instruments, including various chromatography and digestion instruments, in October 2025 [4]. - The Jiangmen Customs Technology Center will procure five laboratory instruments, including a liquid combustion test instrument and a high-pressure sterilizer, in July 2025 [4]. - The Jinan Customs Technology Center aims to enhance its laboratory capabilities by procuring 32 instruments to improve inspection efficiency and accuracy in July 2025 [4]. Group 4: Additional Procurement Initiatives - The Shenyang Customs Technology Center will procure various reagents and consumables, including chemical and biological reagents, with a budget of 1.85 million yuan in September 2025 [5]. - The Shanghai Customs International Travel Health Center plans to update outdated laboratory instruments to enhance testing capabilities with a budget of 3.05 million yuan in August 2025 [7].

Investment Rating - The report does not explicitly state an investment rating for the PCR industry Core Insights - The PCR instrument industry is driven by technological innovation and is expected to grow significantly due to increasing demand for infectious disease diagnostics and the rise of digital PCR instruments [3][34] - The industry is characterized by a high degree of integration within the supply chain, with the reagent market complementing the instrument market [10] - Strict regulatory oversight ensures product quality and safety, which is crucial for the industry's development [11] Summary by Sections Industry Overview - The PCR instrument industry relies on polymerase chain reaction technology, widely used in biomedical fields, and is experiencing continuous performance upgrades [3][4] - The market is expected to expand significantly due to advancements in technology and the broadening of application areas [3] Technology and Product Categories - PCR instruments are categorized into traditional PCR, real-time quantitative PCR, and digital PCR based on quantitative precision [5][6][7] - The industry is witnessing a shift towards integration and intelligence, with innovations such as microfluidics and AI enhancing efficiency and reducing human error [9] Industry Characteristics - The industry is driven by technological innovation, tightly integrated supply chains, and stringent regulatory oversight [8][10][11] - The evolution of PCR technology has progressed through several phases, from manual methods to automated systems, significantly improving efficiency and accuracy [12][13][14] Supply Chain Analysis - The upstream supply chain, including raw material suppliers, plays a critical role in the manufacturing cost and performance of PCR instruments [15][16] - The domestic market is transitioning from reliance on imported equipment to local alternatives, with domestic brands gaining significant market share [17][25] Market Dynamics - The fluorescence quantitative PCR market has reached maturity, with domestic brands capturing a substantial share, increasing from 8% in 2019 to 63% in 2023 [17][26] - The digital PCR market remains dominated by international brands, but domestic companies are making significant inroads in clinical applications [27][28] End-User Demand - The demand for PCR instruments is shifting from hospitals to research institutions, with a notable increase in the need for high-performance, cost-effective solutions [29][30] - The clinical diagnostic laboratories hold the largest market share, driven by the widespread application of digital PCR technology [31] Market Growth Factors - The market for PCR instruments is expected to grow significantly due to advancements in technology and the increasing prevalence of infectious diseases [32][34] - Digital PCR is projected to rise rapidly, complementing fluorescence quantitative PCR in driving market expansion [35]