撰文丨王聪 编辑丨王多鱼 排版丨水成文 癌症患者常伴有抑郁症状 ，这通常是由于他们承受的巨大痛苦所致，这促使研究人员思考 ： 某种特定的 抗抑郁药物是否能够同时有效治疗抑郁和癌症这两种疾病？ 2026 年 1 月 5 日，海军军医大学、江南大学附属医院、中国医科大学的研究人员合作，在 Cell 子刊 Cell Reports Medicine 上发表了题为： 5-HT reuptake blockade induces pyroptosis in BRAF V600E - mutated melanomas via remodeling histone serotonylation 的研究论文。 该研究表明，一种常用的 抗抑郁药物 —— 帕罗西汀 （paroxetine hydrochloride, PH） ，竟能有效对抗 恶性 黑色素瘤 ，尤其是那些携带 BRAF V600E 突变且对靶向治疗产生耐药性的棘手病例。 黑色素瘤 患者通常面临着 双重挑战—— 由于 原发性或获得性耐药导致的治疗选择有限，以及患者普遍存 在的心理困扰，因此，亟需创新的治疗策略。 更令人振奋的是，帕罗西汀对 BRAFi/MEKi 耐 ...

Core Viewpoint - The article discusses the condition of obsessive-compulsive disorder (OCD) through the case of an 18-year-old college student, highlighting its symptoms, treatment options, and the importance of family support in the recovery process [1][2][8]. Summary by Sections Definition and Symptoms - OCD is characterized by obsessive thoughts and compulsive behaviors that significantly impact daily life, work, and relationships [2]. - Obsessive thoughts are intrusive ideas that cause excessive anxiety, while compulsive behaviors are repetitive actions aimed at reducing this anxiety [2]. Treatment Options - First-line treatments for OCD include medication and psychological therapy. Common medications include fluvoxamine, sertraline, paroxetine, and fluoxetine, while cognitive behavioral therapy (CBT) is the most recommended psychological treatment [3]. - Medication typically takes 4 to 6 weeks to show effects, with some initial side effects like dry mouth and drowsiness, which usually subside [3]. - CBT, particularly the exposure and response prevention (ERP) technique, is effective in helping patients manage their anxiety and regain control over their symptoms [5]. Integrated Treatment Approach - The hospital employs an individualized and integrated treatment model that combines medication, psychological therapy, physical therapy, and traditional Chinese medicine to maximize treatment effectiveness [7]. - Patients are encouraged to participate in group therapy and individual sessions to learn coping strategies and become their own therapists [7]. Family Involvement - Family support is crucial in the treatment of OCD, as family members can inadvertently enable the disorder by accommodating the patient's compulsive behaviors [8]. - Education for family members is provided to help them respond appropriately to the patient's symptoms and reduce the risk of relapse after discharge [8]. Additional Treatment Methods - Other treatment methods include physical therapies such as transcranial magnetic stimulation, relaxation techniques, and acupuncture, which complement medication and psychological therapy [9][10]. Recovery Potential - With dedicated effort from both patients and healthcare providers, most individuals with OCD can return to normal life. Long-term commitment to therapy, such as mindfulness practices, can lead to successful outcomes [12].