寒假来临，又到了不少学生集中治疗痤疮（俗称"痘痘"）的高峰期。近日，被誉为"战痘神药"的异维A酸，成了众多患者关注的焦点。 1月6日，国家药品监督管理局发布公告，对异维A酸软胶囊说明书内容进行统一修订。在南方医科大学中西医结合医院皮肤医学中心，门诊已迎来第一波 青少年痤疮就诊潮，其中就有不少家长带着孩子前来咨询是否适用异维A酸。 这款"痤疮神药"可能影响性功能 异维A酸俗称"EVA"，是最近几年在网上走红的所谓"治痘神药"。目前市面上可见的异维A酸产品，既有口服胶囊，也有外用乳膏制剂。很多年轻人把异 维A酸当作战"痘"的法宝，社交媒体也倾向于宣传它的神奇疗效，而忽视或者淡化它的副作用，导致这个药出现了滥用。 最新发布的《异维A酸软胶囊说明书修订要求》明确其不良反应项应包含内分泌、消化、精神、生殖等数十项副作用提示，并修改与新增了两条注意事 项： 若出现抑郁、躁动，以及罕见的自杀、自杀意念和自杀企图等情况，患者应立即停药； 已有异维A酸可能引起性功能障碍的个例报告，个别患者停用异维A酸后性功能障碍相关症状仍长期存在，可能需要专科治疗。 此外，不良反应项还补充了内分泌、消化、肌肉骨骼等数十项副作用提示。国家药监局 ...

中国 根据最新发布的《异维A酸软胶囊说明书修订要求》，其不良反应项应包含内分泌、消化、精神、生殖 等数十项副作用提示，修改与新增两条注意事项提示，若出现抑郁、躁动，以及罕见的自杀、自杀意念 和自杀企图等情况，患者应立即停药；已有异维A酸可能引起性功能障碍的个例报告，个别患者停用异 维A酸后性功能障碍相关症状仍长期存在，可能需要专科治疗。 事实上，关于异维A酸的副作用争议早已存在。记者在某社交平台看到，不少网友分享用药体验，有人 表示服用一个半月后明显感觉皮肤、嘴唇干燥，但痘痘好转，认为"利大于弊"；也有网友称"第一次吃 就抑郁到半夜流眼泪，还失眠、便秘，只能重新挂号评估是否要继续服药"。 "异维A酸主要用于治疗痤疮，因为它能同时阻断痤疮发病的4大环节，临床疗效优越。"东南大学附属 中大医院皮肤科副主任医师粟倩雅指出，异维A酸尤其适用于重度难治性结节性痤疮，具有"无可替 代"的地位。治疗策略是灵活的，一般从常规剂量开始，病情控制后逐渐减量，然后维持剂量或者停 药，这种方式有助于降低不良反应风险。整个治疗周期通常为数月。 粟倩雅提到，异维A酸的不良反应虽然听起来很多，但大部分是常见、轻微且可控的。她介绍，最常见 ...

Core Insights - The article highlights the successful consultation of Professor Tu Ping, a renowned dermatologist from Peking University First Hospital, who provided specialized treatment for difficult skin diseases in Jinan, attracting patients from various regions [1][2]. Group 1: Patient Case Study - A 23-year-old patient, Mr. Li, traveled from Guangdong to seek help for severe skin issues that had persisted for six months, significantly affecting his quality of life [1]. - Mr. Li experienced adverse effects from isotretinoin treatment, leading to symptoms such as nasal bleeding, facial redness, and persistent dryness, which worsened after stopping the medication [1][2]. - After a thorough examination, Professor Tu diagnosed Mr. Li with atopic dermatitis and created a personalized treatment plan that combined Western and traditional Chinese medicine [2]. Group 2: Consultation Outcomes - During the consultation, Professor Tu treated over 40 patients, successfully diagnosing and formulating individualized treatment plans for various rare skin conditions, including lymphocytic infiltration and mycosis fungoides [2]. - The detailed consultations and tailored treatment strategies provided hope to many families struggling with skin diseases [2]. Group 3: Future Engagements - Professor Tu is scheduled to return to Jinan for another consultation on January 27, 2026, allowing more patients to seek his expertise [3].

Core Viewpoint - The article highlights the widespread issue of acne among adolescents in China, emphasizing the psychological and social impacts it has on individuals, and the need for timely and effective treatment rather than the common misconception that it is a normal part of growing up [19][21]. Group 1: Prevalence and Impact of Acne - A study indicates that 95% of individuals experience some degree of acne, with 3% to 7% of patients developing scars [1]. - Many adolescents face self-esteem issues and social anxiety due to acne, which can affect their personal and professional lives [1][19]. Group 2: Treatment Challenges - Parents often resort to ineffective home remedies or delay seeking professional help, believing that acne will resolve on its own [19][21]. - The article discusses various treatment experiences, including the use of topical medications and oral antibiotics, which often come with side effects and limited effectiveness [20]. Group 3: Psychological Effects - Acne can lead to significant emotional distress, with many individuals feeling self-conscious and avoiding social interactions [19][21]. - The stigma associated with acne can exacerbate feelings of isolation and anxiety among affected adolescents [19]. Group 4: Need for Awareness and Education - There is a lack of understanding about acne among the general population, with 60.4% of people not fully aware of the condition [19]. - The article calls for increased awareness and education for both parents and adolescents regarding the importance of early intervention and proper treatment [21]. Group 5: Advances in Treatment - Recent guidelines and advancements in acne treatment are being introduced, aiming to provide safer and more effective options for patients [20]. - The introduction of new technologies and treatment methods is seen as a positive step towards addressing the acne epidemic among youth [20].

Group 1 - The article discusses the significant physiological changes women experience during pregnancy and postpartum, highlighting the risks associated with cosmetic treatments during these periods [1] - It emphasizes that many women seek aesthetic improvements after childbirth, but medical professionals caution against premature cosmetic procedures due to potential adverse effects [1] - The article provides expert answers to common questions regarding cosmetic treatments during pregnancy and postpartum, focusing on safety and timing [2][3][4][5] Group 2 - Acne during pregnancy is linked to hormonal fluctuations, and while mild cases can be managed with gentle skincare, more aggressive treatments should wait until after breastfeeding [2] - Postpartum aesthetic procedures, such as facial fillers, should ideally be postponed until after breastfeeding or at least one year postpartum due to safety concerns [3] - The article notes that 70% of melasma during pregnancy may resolve within a year postpartum, suggesting minimal intervention during this time [4] Group 3 - The increase in skin tags and other benign growths during pregnancy is a common physiological response, and most can be monitored until after breastfeeding [5] - The article reassures that accidental cosmetic treatments like Botox or laser procedures are unlikely to harm the fetus, but emphasizes the lack of safety data during pregnancy and breastfeeding [7] - Recommendations for managing surgical scars post-C-section include specialized suturing techniques and extended healing time to minimize scarring [8] Group 4 - The article advises that postpartum body changes are normal and should be addressed through diet and exercise before considering cosmetic procedures [9] - It discusses the prevention and treatment of stretch marks, recommending weight control and skin hydration during pregnancy, with limited treatment options available postpartum [10] - Postpartum hair loss is typically temporary, with most women recovering within 6-12 months, but treatments can be considered if the issue persists beyond this period [11]