中国 根据最新发布的《异维A酸软胶囊说明书修订要求》，其不良反应项应包含内分泌、消化、精神、生殖 等数十项副作用提示，修改与新增两条注意事项提示，若出现抑郁、躁动，以及罕见的自杀、自杀意念 和自杀企图等情况，患者应立即停药；已有异维A酸可能引起性功能障碍的个例报告，个别患者停用异 维A酸后性功能障碍相关症状仍长期存在，可能需要专科治疗。 事实上，关于异维A酸的副作用争议早已存在。记者在某社交平台看到，不少网友分享用药体验，有人 表示服用一个半月后明显感觉皮肤、嘴唇干燥，但痘痘好转，认为"利大于弊"；也有网友称"第一次吃 就抑郁到半夜流眼泪，还失眠、便秘，只能重新挂号评估是否要继续服药"。 "异维A酸主要用于治疗痤疮，因为它能同时阻断痤疮发病的4大环节，临床疗效优越。"东南大学附属 中大医院皮肤科副主任医师粟倩雅指出，异维A酸尤其适用于重度难治性结节性痤疮，具有"无可替 代"的地位。治疗策略是灵活的，一般从常规剂量开始，病情控制后逐渐减量，然后维持剂量或者停 药，这种方式有助于降低不良反应风险。整个治疗周期通常为数月。 粟倩雅提到，异维A酸的不良反应虽然听起来很多，但大部分是常见、轻微且可控的。她介绍，最常见 ...

【#执业药师回应吃完药狂买彩票停药不买#，属药物副作用发生率极低】1月30日（报道），有网友近 日分享，称吃完一款药后就疯狂买彩票，刮奖彩票购买量达到"按斤称"的程度。导致这一行为的原因被 他归咎为一款名为"甲磺酸溴隐亭片"的处方药。网友描述，当他停药后，这种狂买彩票的行为完全消 失。翻查药品说明书，才发现该药物在精神异常副作用中明确列出"病理性赌博"的字样。据执业药师介 绍，甲磺酸溴隐亭片确实可能这种异常行为，服用后会导致冲动控制障碍，使患者对高风险高回报行为 产生异常渴求，但这属于罕见副作用，发生率极低，低于1/10000。（闪电新闻） （来源：猛犸新闻） ...

Core Viewpoint - The Danish pharmaceutical company Novo Nordisk's semaglutide drugs, Ozempic and Wegovy, are reported to potentially cause severe vision impairment, specifically a rare side effect known as NAION, leading to compensation claims from affected patients [2][5]. Group 1: Patient Compensation Claims - A total of 43 patients have filed compensation claims with the Danish Patient Compensation Association after experiencing NAION following the use of Ozempic or Wegovy [2]. - The association has ruled on the first five cases, granting compensation in four instances, while one case was dismissed [2]. - The total compensation amount for the four patients is approximately 800,000 Danish kroner (around 878,000 RMB), with potential increases if patients suffer income loss due to NAION [5]. Group 2: Nature of NAION - NAION is described as a serious condition affecting the front part of the optic nerve, potentially leading to permanent vision loss and field defects [1][5]. - The occurrence rate of NAION due to semaglutide is reported to be less than 0.01% [5]. Group 3: Regulatory Actions and Research - The Danish Medicines Agency issued a warning to the European Medicines Agency based on two large Danish studies indicating a link between semaglutide and NAION [5]. - The European Medicines Agency confirmed that NAION is a rare side effect of Wegovy, Ozempic, and Rybelsus [5]. Group 4: Patient Population and Side Effects - It is estimated that by the end of 2025, over 50 million people globally will have used semaglutide, with around 22-25 million for diabetes treatment and 16-18 million for weight loss [6]. - Common side effects of semaglutide include gastrointestinal reactions, while severe side effects can include acute pancreatitis and gallbladder disease [6].

Core Viewpoint - Novo Nordisk's weight loss drug semaglutide has been linked to severe vision damage, with 43 patients filing for compensation in Denmark due to a rare side effect known as NAION [1][4][5] Group 1: Patient Compensation and Legal Proceedings - The Danish Patient Compensation Association reported that 43 patients experienced severe eye disease NAION after using Ozempic or Wegovy, with initial rulings on five cases resulting in four compensations [1][2] - The total compensation for the four patients is approximately 800,000 Danish kroner (about 878,000 RMB), with potential increases if patients suffer income loss due to NAION [4] Group 2: Medical and Regulatory Insights - NAION is a serious condition affecting the optic nerve, potentially leading to vision loss and is considered a rare side effect of semaglutide-containing drugs [4][5] - The Danish Medicines Agency issued a warning based on two large studies indicating a link between NAION and semaglutide, with the European Medicines Agency confirming this association in June 2025 [4][5] Group 3: Market and Usage Statistics - Despite the low incidence rate of NAION (less than 0.01%), the large patient population using semaglutide raises concerns about other complications and side effects [5] - By the end of 2025, it is estimated that over 50 million people globally will have used semaglutide, with approximately 22-25 million for diabetes treatment and 16-18 million for weight loss [5]