以下文章来源于肥胖世界ObesityWorld ，作者欢迎订阅 肥胖世界ObesityWorld . 《肥胖世界》Obesity World - 同步传真肥胖及代谢国际新学术进展，为医学减重临床、教研人员搭建一座与国际接轨的桥梁，「每医健」旗下内容平台。 3. 科学机制揭秘：基于动物和受试者的数据，研究揭示抗性淀粉可通过改变肠道菌群，进而影响胆汁酸代谢、减少炎症、修复肠道屏障和抑制 脂质吸收等多重通路起效，这一系列发现为未来肥胖防治方案的研发提供了全新理论基础。 上海交通大学贾伟平团队近日在《Nature Metabolism》杂志发表了一项最新研究。团队通过"肠道微生物组+代谢组学"的多维分析，证实补充 抗性淀粉（RS）能够显著帮助超重或肥胖人群减轻体重。以下是研究亮点解析： 1. 多组学综合评估：本项研究整合了微生物组和代谢组学数据，系统考察了抗性淀粉对肠道菌群结构以及人体代谢的全方位影响。 2. 临床试验创新：研究采用随机、安慰剂对照的交叉试验设计，有效降低了混杂变量，提升了结果的可靠性，是目前食品干预体重管理领域较 为创新的研究思路。 研究背景： 本项研究聚焦于全球范围内日益严重的肥胖难题，探讨了抗性 ...

Core Viewpoint - The article discusses a recent study published in *Nature Metabolism* by a team from Shanghai Jiao Tong University, which demonstrates that resistant starch (RS) can significantly aid overweight or obese individuals in weight loss and improving metabolic health through modulation of gut microbiota and metabolic pathways [6][8]. Group 1: Research Highlights - The study integrates microbiome and metabolomics data to comprehensively assess the impact of resistant starch on gut microbiota structure and human metabolism [6]. - It employs a randomized, placebo-controlled crossover trial design, enhancing the reliability of results by minimizing confounding variables [6]. - The research reveals that resistant starch affects bile acid metabolism, reduces inflammation, repairs gut barriers, and inhibits lipid absorption, providing a new theoretical basis for obesity prevention and treatment [6][8]. Group 2: Study Methodology - The study included participants aged 18 to 55 years, classified as overweight or obese (BMI ≥ 24 kg/m²), and excluded those with acute diseases or recent antibiotic use [9]. - A randomized controlled crossover design was used to evaluate the effects of resistant starch on weight control and insulin resistance, combined with metagenomic and metabolomic techniques to analyze gut microbiota changes [10]. Group 3: Key Findings - The intervention with resistant starch resulted in significant weight loss, reduced fat mass, and improved insulin sensitivity among 37 overweight or obese participants over an 8-week period [11]. - Resistant starch increased the abundance of beneficial bacteria such as *Bifidobacterium*, enhancing gut barrier function and reducing inflammation [11][13]. - In animal models, the transplantation of gut microbiota from resistant starch-fed humans led to lower body weight and fat mass, indicating the effectiveness of RS-modulated gut microbiota in weight management [16]. Group 4: Mechanisms of Action - The study found that resistant starch-induced gut microbiota changes lowered systemic inflammation markers and improved gut barrier integrity, which is crucial for managing obesity-related chronic inflammation [18][19]. - The increase in *Bifidobacterium adolescentis* was closely linked to the alleviation of abdominal obesity, suggesting its potential role in metabolic health [21].