Core Viewpoint - Scientific weight loss should be based on personalized assessments, as many individuals overlook personal differences and blindly follow others' weight loss plans, leading to poor results or health risks [1][3]. Group 1: Obesity Statistics and Health Impact - The overweight rate among Chinese adults has reached 34.3%, with an obesity rate of 16.4%, making obesity a significant public health threat [1]. - Overweight and obesity are major contributing factors to various chronic diseases, prompting the launch of a three-year "Weight Management Year" initiative by the National Health Commission and 16 other departments [1]. Group 2: Weight Management Encyclopedia - The "National Weight Management Encyclopedia" is the first comprehensive weight management resource aimed at the general public, focusing on the "medical, dietary, exercise, and behavioral" health system [2]. - The encyclopedia consists of three volumes: "Medical," "Diet," and "Management," addressing key issues in weight management with scientific backing and practical knowledge [2]. Group 3: Personalized Weight Management Approach - Effective weight management requires a multi-dimensional improvement in lifestyle habits, including medical evaluations to rule out secondary obesity factors and tailored plans based on age, underlying conditions, and lifestyle [3]. - The event included interactive sessions and body composition testing to help the public transition from understanding science to applying it in daily life [3]. - Obesity prevention and treatment is a systemic project that necessitates community involvement and the establishment of a multidisciplinary treatment model for comprehensive intervention [3].

Core Viewpoint - The conference emphasized that obesity is a complex chronic disease involving multiple factors such as metabolism, genetics, behavior, and diet, requiring long-term scientific management and multidisciplinary collaboration for effective prevention and treatment [1] Group 1: Medical Nutrition Treatment - Medical nutrition therapy is fundamental in treating obesity, serving as a core measure for prevention and control of obesity and related complications [2] - The "14th Five-Year Plan" highlights the importance of comprehensive prevention and control of chronic diseases, while the "Healthy China 2030" plan emphasizes individual responsibility for health and the "three reductions" (reducing oil, salt, and sugar) [2] - The concept of "medical weight management" was promoted, focusing on safe and effective weight management under medical supervision to improve metabolic conditions [2] Group 2: Multidisciplinary Collaboration - Obesity requires a multidisciplinary approach, with different specialties focusing on various aspects of patient care, including endocrinology, nutrition, and exercise medicine [2] - After diagnosing obesity, collaboration among various departments is essential to create scientific treatment plans that not only focus on weight loss but also on improving related health conditions [2] Group 3: Development of Weight Management Products - The development of medical nutrition weight loss products should be based on nutritional intervention principles, balancing nutritional needs with individual requirements [3] - The emerging health weight management centers provide personalized and scientific weight management solutions through evidence-based medicine and multidisciplinary collaboration [3] Group 4: National Initiatives and Guidelines - In 2024, a joint implementation plan for "Weight Management Year" encourages healthcare institutions to establish weight management clinics or obesity prevention centers [4] - The latest "Obesity Diagnosis and Treatment Guidelines (2024 Edition)" provides systematic norms from etiology and diagnostic assessment to multidisciplinary collaborative treatment [4] - The establishment of a comprehensive weight management service system across the country is supported by various industry standards and guidelines, facilitating clinical practice [4]

以下文章来源于肥胖世界ObesityWorld ，作者欢迎订阅 肥胖世界ObesityWorld . 《肥胖世界》Obesity World - 同步传真肥胖及代谢国际新学术进展，为医学减重临床、教研人员搭建一座与国际接轨的桥梁，「每医健」旗下内容平台。 3. 科学机制揭秘：基于动物和受试者的数据，研究揭示抗性淀粉可通过改变肠道菌群，进而影响胆汁酸代谢、减少炎症、修复肠道屏障和抑制 脂质吸收等多重通路起效，这一系列发现为未来肥胖防治方案的研发提供了全新理论基础。 上海交通大学贾伟平团队近日在《Nature Metabolism》杂志发表了一项最新研究。团队通过"肠道微生物组+代谢组学"的多维分析，证实补充 抗性淀粉（RS）能够显著帮助超重或肥胖人群减轻体重。以下是研究亮点解析： 1. 多组学综合评估：本项研究整合了微生物组和代谢组学数据，系统考察了抗性淀粉对肠道菌群结构以及人体代谢的全方位影响。 2. 临床试验创新：研究采用随机、安慰剂对照的交叉试验设计，有效降低了混杂变量，提升了结果的可靠性，是目前食品干预体重管理领域较 为创新的研究思路。 研究背景： 本项研究聚焦于全球范围内日益严重的肥胖难题，探讨了抗性 ...

Core Viewpoint - The article discusses a recent study published in *Nature Metabolism* by a team from Shanghai Jiao Tong University, which demonstrates that resistant starch (RS) can significantly aid overweight or obese individuals in weight loss and improving metabolic health through modulation of gut microbiota and metabolic pathways [6][8]. Group 1: Research Highlights - The study integrates microbiome and metabolomics data to comprehensively assess the impact of resistant starch on gut microbiota structure and human metabolism [6]. - It employs a randomized, placebo-controlled crossover trial design, enhancing the reliability of results by minimizing confounding variables [6]. - The research reveals that resistant starch affects bile acid metabolism, reduces inflammation, repairs gut barriers, and inhibits lipid absorption, providing a new theoretical basis for obesity prevention and treatment [6][8]. Group 2: Study Methodology - The study included participants aged 18 to 55 years, classified as overweight or obese (BMI ≥ 24 kg/m²), and excluded those with acute diseases or recent antibiotic use [9]. - A randomized controlled crossover design was used to evaluate the effects of resistant starch on weight control and insulin resistance, combined with metagenomic and metabolomic techniques to analyze gut microbiota changes [10]. Group 3: Key Findings - The intervention with resistant starch resulted in significant weight loss, reduced fat mass, and improved insulin sensitivity among 37 overweight or obese participants over an 8-week period [11]. - Resistant starch increased the abundance of beneficial bacteria such as *Bifidobacterium*, enhancing gut barrier function and reducing inflammation [11][13]. - In animal models, the transplantation of gut microbiota from resistant starch-fed humans led to lower body weight and fat mass, indicating the effectiveness of RS-modulated gut microbiota in weight management [16]. Group 4: Mechanisms of Action - The study found that resistant starch-induced gut microbiota changes lowered systemic inflammation markers and improved gut barrier integrity, which is crucial for managing obesity-related chronic inflammation [18][19]. - The increase in *Bifidobacterium adolescentis* was closely linked to the alleviation of abdominal obesity, suggesting its potential role in metabolic health [21].

Core Viewpoint - The article emphasizes the increasing prevalence of obesity and related chronic diseases in China, highlighting the government's initiative to implement a "Weight Management Year" program starting in 2024 to promote healthy lifestyles and weight management awareness among the population [2][5][21]. Group 1: Government Initiatives - The National Health Commission and 16 other departments have developed a plan to establish a supportive environment for weight management, aiming for significant improvements in public awareness and skills related to weight management over the next three years [2][3]. - During the National People's Congress, the director of the National Health Commission reiterated the commitment to promote weight management and healthy lifestyle habits across society [2][3]. Group 2: Public Health Concerns - Obesity is identified as a major public health issue, with projections indicating that by 2030, the overweight and obesity rate among adults in China could reach 65.3%, leading to medical costs of approximately 418 billion yuan, which accounts for 21.5% of the total national medical expenses [5][21]. - The article stresses the urgent need for a multi-departmental and interdisciplinary approach to effectively address the obesity epidemic and its economic burden [5][21]. Group 3: Collaborative Efforts - The establishment of the China Obesity Alliance, initiated by leading experts, aims to enhance public health through various activities, including the China Obesity Conference and the "Scientific Weight Loss" campaign [6][7]. - The Southern Finance Media Group has actively engaged in social mobilization to promote healthy living and weight management, contributing to the "Healthy China 2030" initiative [3][5][21]. Group 4: Educational and Community Engagement - The article highlights various community events and initiatives, such as the "Weight Down, Health Up" campaign, aimed at encouraging public participation in weight management and healthy lifestyle practices [9][10]. - The Southern Finance Media Group has organized health education activities, including expert consultations and public health campaigns, to raise awareness about obesity and its management [13][19]. Group 5: Standardization and Professional Development - The article discusses the importance of establishing standardized weight management centers and multidisciplinary weight loss clinics to provide comprehensive care for obesity patients [22][24]. - Efforts are being made to enhance the professional skills of healthcare providers and to utilize digital tools for effective weight management [24][26].