新京报讯(记者王卡拉)11月14日—16日，在由中国医促会临床营养健康学分会主办的"第八届华夏医学 营养论坛暨医学体重管理门诊的建设与规范化管理培训会议"上，减重相关多学科医学专家强调，肥胖 不是单纯的"体型问题"，而是涉及代谢、遗传、行为、饮食等多因素的复杂慢性疾病，其防治需要长期 科学管理，更离不开多学科团队的协同发力。随着更多医疗机构加入医学减重教学网络及各项指南规范 的深入落地，我国体重管理服务体系将不断完善。 医学营养治疗作为肥胖症治疗的基础，是贯穿肥胖自然病程、预防和控制肥胖及相关并发症的核心措 施，为科学减重提供了关键支撑。北京协和医院临床营养科陈伟教授指出，"十五五"规划建议中强调了 加强慢性病综合防控的重要性。《"健康中国2030"规划纲要》也提出，每个人是自己健康的第一责任 人，并强调了"三减"(减油、减盐、减糖)，实现健康口腔、健康体重、健康骨骼。"实际上这三个健康是 我们进行慢病防治的重要抓手。本次大会中特别倡导了'医学体重管理'这样一个名词，重点强调用医疗 的手段，即在医生的监督防控之下，让体重管理变得更安全、更有效，更加能够改善机体的代谢状况， 所以体重管理应该是慢病防治的桥头堡。 ...

以下文章来源于肥胖世界ObesityWorld ，作者欢迎订阅 肥胖世界ObesityWorld . 《肥胖世界》Obesity World - 同步传真肥胖及代谢国际新学术进展，为医学减重临床、教研人员搭建一座与国际接轨的桥梁，「每医健」旗下内容平台。 3. 科学机制揭秘：基于动物和受试者的数据，研究揭示抗性淀粉可通过改变肠道菌群，进而影响胆汁酸代谢、减少炎症、修复肠道屏障和抑制 脂质吸收等多重通路起效，这一系列发现为未来肥胖防治方案的研发提供了全新理论基础。 上海交通大学贾伟平团队近日在《Nature Metabolism》杂志发表了一项最新研究。团队通过"肠道微生物组+代谢组学"的多维分析，证实补充 抗性淀粉（RS）能够显著帮助超重或肥胖人群减轻体重。以下是研究亮点解析： 1. 多组学综合评估：本项研究整合了微生物组和代谢组学数据，系统考察了抗性淀粉对肠道菌群结构以及人体代谢的全方位影响。 2. 临床试验创新：研究采用随机、安慰剂对照的交叉试验设计，有效降低了混杂变量，提升了结果的可靠性，是目前食品干预体重管理领域较 为创新的研究思路。 研究背景： 本项研究聚焦于全球范围内日益严重的肥胖难题，探讨了抗性 ...

Core Viewpoint - The article discusses a recent study published in *Nature Metabolism* by a team from Shanghai Jiao Tong University, which demonstrates that resistant starch (RS) can significantly aid overweight or obese individuals in weight loss and improving metabolic health through modulation of gut microbiota and metabolic pathways [6][8]. Group 1: Research Highlights - The study integrates microbiome and metabolomics data to comprehensively assess the impact of resistant starch on gut microbiota structure and human metabolism [6]. - It employs a randomized, placebo-controlled crossover trial design, enhancing the reliability of results by minimizing confounding variables [6]. - The research reveals that resistant starch affects bile acid metabolism, reduces inflammation, repairs gut barriers, and inhibits lipid absorption, providing a new theoretical basis for obesity prevention and treatment [6][8]. Group 2: Study Methodology - The study included participants aged 18 to 55 years, classified as overweight or obese (BMI ≥ 24 kg/m²), and excluded those with acute diseases or recent antibiotic use [9]. - A randomized controlled crossover design was used to evaluate the effects of resistant starch on weight control and insulin resistance, combined with metagenomic and metabolomic techniques to analyze gut microbiota changes [10]. Group 3: Key Findings - The intervention with resistant starch resulted in significant weight loss, reduced fat mass, and improved insulin sensitivity among 37 overweight or obese participants over an 8-week period [11]. - Resistant starch increased the abundance of beneficial bacteria such as *Bifidobacterium*, enhancing gut barrier function and reducing inflammation [11][13]. - In animal models, the transplantation of gut microbiota from resistant starch-fed humans led to lower body weight and fat mass, indicating the effectiveness of RS-modulated gut microbiota in weight management [16]. Group 4: Mechanisms of Action - The study found that resistant starch-induced gut microbiota changes lowered systemic inflammation markers and improved gut barrier integrity, which is crucial for managing obesity-related chronic inflammation [18][19]. - The increase in *Bifidobacterium adolescentis* was closely linked to the alleviation of abdominal obesity, suggesting its potential role in metabolic health [21].

Core Viewpoint - The article emphasizes the increasing prevalence of obesity and related chronic diseases in China, highlighting the government's initiative to implement a "Weight Management Year" program starting in 2024 to promote healthy lifestyles and weight management awareness among the population [2][5][21]. Group 1: Government Initiatives - The National Health Commission and 16 other departments have developed a plan to establish a supportive environment for weight management, aiming for significant improvements in public awareness and skills related to weight management over the next three years [2][3]. - During the National People's Congress, the director of the National Health Commission reiterated the commitment to promote weight management and healthy lifestyle habits across society [2][3]. Group 2: Public Health Concerns - Obesity is identified as a major public health issue, with projections indicating that by 2030, the overweight and obesity rate among adults in China could reach 65.3%, leading to medical costs of approximately 418 billion yuan, which accounts for 21.5% of the total national medical expenses [5][21]. - The article stresses the urgent need for a multi-departmental and interdisciplinary approach to effectively address the obesity epidemic and its economic burden [5][21]. Group 3: Collaborative Efforts - The establishment of the China Obesity Alliance, initiated by leading experts, aims to enhance public health through various activities, including the China Obesity Conference and the "Scientific Weight Loss" campaign [6][7]. - The Southern Finance Media Group has actively engaged in social mobilization to promote healthy living and weight management, contributing to the "Healthy China 2030" initiative [3][5][21]. Group 4: Educational and Community Engagement - The article highlights various community events and initiatives, such as the "Weight Down, Health Up" campaign, aimed at encouraging public participation in weight management and healthy lifestyle practices [9][10]. - The Southern Finance Media Group has organized health education activities, including expert consultations and public health campaigns, to raise awareness about obesity and its management [13][19]. Group 5: Standardization and Professional Development - The article discusses the importance of establishing standardized weight management centers and multidisciplinary weight loss clinics to provide comprehensive care for obesity patients [22][24]. - Efforts are being made to enhance the professional skills of healthcare providers and to utilize digital tools for effective weight management [24][26].