肥胖防治

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Nature旗下子刊引爆热议:减肥潮流下,主食迎来新机遇!上海交通大学贾伟平团队重磅发布“肠道菌群联动代谢组”新突破
GLP1减重宝典· 2025-09-29 10:38
Core Viewpoint - The article discusses a recent study published in *Nature Metabolism* by a team from Shanghai Jiao Tong University, which demonstrates that resistant starch (RS) can significantly aid overweight or obese individuals in weight loss and improving metabolic health through modulation of gut microbiota and metabolic pathways [6][8]. Group 1: Research Highlights - The study integrates microbiome and metabolomics data to comprehensively assess the impact of resistant starch on gut microbiota structure and human metabolism [6]. - It employs a randomized, placebo-controlled crossover trial design, enhancing the reliability of results by minimizing confounding variables [6]. - The research reveals that resistant starch affects bile acid metabolism, reduces inflammation, repairs gut barriers, and inhibits lipid absorption, providing a new theoretical basis for obesity prevention and treatment [6][8]. Group 2: Study Methodology - The study included participants aged 18 to 55 years, classified as overweight or obese (BMI ≥ 24 kg/m²), and excluded those with acute diseases or recent antibiotic use [9]. - A randomized controlled crossover design was used to evaluate the effects of resistant starch on weight control and insulin resistance, combined with metagenomic and metabolomic techniques to analyze gut microbiota changes [10]. Group 3: Key Findings - The intervention with resistant starch resulted in significant weight loss, reduced fat mass, and improved insulin sensitivity among 37 overweight or obese participants over an 8-week period [11]. - Resistant starch increased the abundance of beneficial bacteria such as *Bifidobacterium*, enhancing gut barrier function and reducing inflammation [11][13]. - In animal models, the transplantation of gut microbiota from resistant starch-fed humans led to lower body weight and fat mass, indicating the effectiveness of RS-modulated gut microbiota in weight management [16]. Group 4: Mechanisms of Action - The study found that resistant starch-induced gut microbiota changes lowered systemic inflammation markers and improved gut barrier integrity, which is crucial for managing obesity-related chronic inflammation [18][19]. - The increase in *Bifidobacterium adolescentis* was closely linked to the alleviation of abdominal obesity, suggesting its potential role in metabolic health [21].
引领“体重管理年”,南方财经全媒体集团全方位构筑健康生态新格局
21世纪经济报道· 2025-03-12 10:35
Core Viewpoint - The article emphasizes the increasing prevalence of obesity and related chronic diseases in China, highlighting the government's initiative to implement a "Weight Management Year" program starting in 2024 to promote healthy lifestyles and weight management awareness among the population [2][5][21]. Group 1: Government Initiatives - The National Health Commission and 16 other departments have developed a plan to establish a supportive environment for weight management, aiming for significant improvements in public awareness and skills related to weight management over the next three years [2][3]. - During the National People's Congress, the director of the National Health Commission reiterated the commitment to promote weight management and healthy lifestyle habits across society [2][3]. Group 2: Public Health Concerns - Obesity is identified as a major public health issue, with projections indicating that by 2030, the overweight and obesity rate among adults in China could reach 65.3%, leading to medical costs of approximately 418 billion yuan, which accounts for 21.5% of the total national medical expenses [5][21]. - The article stresses the urgent need for a multi-departmental and interdisciplinary approach to effectively address the obesity epidemic and its economic burden [5][21]. Group 3: Collaborative Efforts - The establishment of the China Obesity Alliance, initiated by leading experts, aims to enhance public health through various activities, including the China Obesity Conference and the "Scientific Weight Loss" campaign [6][7]. - The Southern Finance Media Group has actively engaged in social mobilization to promote healthy living and weight management, contributing to the "Healthy China 2030" initiative [3][5][21]. Group 4: Educational and Community Engagement - The article highlights various community events and initiatives, such as the "Weight Down, Health Up" campaign, aimed at encouraging public participation in weight management and healthy lifestyle practices [9][10]. - The Southern Finance Media Group has organized health education activities, including expert consultations and public health campaigns, to raise awareness about obesity and its management [13][19]. Group 5: Standardization and Professional Development - The article discusses the importance of establishing standardized weight management centers and multidisciplinary weight loss clinics to provide comprehensive care for obesity patients [22][24]. - Efforts are being made to enhance the professional skills of healthcare providers and to utilize digital tools for effective weight management [24][26].