TPN171是一款PDE5抑制剂，于2022年9月在乌兹别克斯坦获批上市，商品名为Onvita ，于2025年7月在 中国获批上市，商品名为昂伟达 ，获批适应症均为男性勃起功能障碍（ED)。在中国，PDE5抑制剂于 2024年的市场价值为人民币93亿元，且预计于2035年达到人民币150亿元。 旺山旺水董事长兼总经理田广辉博士表示："旺山旺水成功在港股上市，是公司发展史上的重要里程 碑，将为公司带来新的资本助力，加快在研产品的研发进程，助力昂伟达 市场拓展和商业化进程，为 公司的长期可持续发展奠定坚实基础。" 今年以来，已有维昇药业、映恩生物、拨康视云等苏州生物医药企业登陆港交所。据苏州市委金融办消 息，截至10月末，苏州共有14家上市后备企业拟申报港交所，其中5家公司已经完成证监会国际司备 案，其他9家均在证监会备案中。截至目前，苏州已有上市公司280家。其中，境内A股226家，数量位 居全国第五。今年以来，苏州全市新增境内外上市公司15家，其中境内上市8家。 旺山旺水成立于2013年，是一家综合一体化创新小分子药物公司，总部位于苏州工业园区。自成立以 来，旺山旺水以创新改善患者的健康和生活质量为使命，致力 ...

Core Viewpoint - The article discusses the potential IPO of Wangshan Wangshui, focusing on its flagship product "domestic Viagra" Angweida, while highlighting the company's broader portfolio of nine innovative assets in three key areas: antiviral, neuropsychiatric, and reproductive health [2][3]. Group 1: Company Overview - Wangshan Wangshui has a valuation of 4.45 billion yuan and is preparing for an accelerated IPO process after submitting its prospectus to the Hong Kong Stock Exchange [2][3]. - The company faces significant challenges, including tight cash flow, idle production capacity, high debt levels, and a concentrated customer base [3][11]. Group 2: Market Trends - The core trends in the industry include innovative drug development targeting RNA viruses and new antidepressant mechanisms, international expansion leveraging the Belt and Road Initiative, and increasing price pressures due to dynamic adjustments in the national medical insurance catalog [5][6]. Group 3: Competitive Landscape - The antiviral drug market is projected to grow from 203 billion yuan in 2024 to 403 billion yuan in 2035, with a compound annual growth rate (CAGR) of 6.3%, while the neuropsychiatric and reproductive health sectors face intense competition with lower growth rates [7]. - Wangshan Wangshui's reliance on a single major customer, which accounted for over 70% of its revenue, poses a significant risk [11][12]. Group 4: Financial Performance - The company reported a net profit of 6.4 million yuan in 2023, primarily from licensing income, but is projected to incur a net loss of 218 million yuan in 2024 due to increased R&D expenses and the termination of licensing income [16]. - Cash flow has deteriorated, with operating cash flow turning negative in 2024, and total liabilities increasing from 488 million yuan in 2023 to 641 million yuan in 2025 [17][16]. Group 5: R&D and Commercialization - Wangshan Wangshui's R&D spending is only 10% of the industry average, and it has significantly fewer patents compared to leading competitors [13]. - The company plans to use IPO proceeds primarily for product development and capacity expansion, including clinical trials for its core products [19][20]. Group 6: Risks and Challenges - The company faces potential issues such as underutilization of existing production capacity, long R&D cycles without core product approvals, and a heavy reliance on self-research and production strategies [22][23]. - Historical examples from peers indicate that unprofitable biotech companies face stringent valuation scrutiny, raising concerns about Wangshan Wangshui's ability to navigate similar challenges [24].