Core Viewpoint - The report outlines the ongoing supervision and assessment of Shenzhen Huada Intelligent Manufacturing Co., Ltd. (华大智造) by CITIC Securities during its initial public offering and listing on the Sci-Tech Innovation Board, emphasizing compliance with regulatory requirements and the absence of significant issues during the review period [1][3][32]. Group 1: Continuous Supervision Overview - CITIC Securities has established a continuous supervision work system and a corresponding work plan, clarifying the requirements for on-site inspections [1]. - The sponsor has signed a sponsorship agreement with the company, which specifies the rights and obligations of both parties during the supervision period [1]. Group 2: Findings and Issues - During the supervision period, no significant issues were identified by the sponsor or the representative [3]. - The company faces risks related to significant performance declines or losses due to high R&D investments and market expansion costs, particularly if international relations worsen or macroeconomic conditions deteriorate [4]. Group 3: Core Competitiveness Risks - The company operates in a technology-intensive life sciences sector, facing risks related to product upgrades and technological updates, which require substantial R&D investments [5][6]. - Risks include the potential loss of core technical talent and the leakage of core technologies, which could adversely affect the company's long-term development [6]. - The company is also exposed to intellectual property litigation risks, particularly from competitors like Illumina, which could limit its market expansion in affected regions [7]. Group 4: Operational Risks - The global gene sequencing industry is rapidly evolving with increasing competition, particularly from established players like Illumina and Thermo Fisher [8]. - The company has developed a diverse product matrix but faces challenges due to economic downturns and regulatory pressures affecting market growth [9]. - New business and customer expansion efforts are critical, as the company must adapt to market demands and regulatory environments [10]. Group 5: Financial Risks - The company has adjusted its pricing strategy in response to competitive pressures, which has led to fluctuations in gross margins [12]. - There is a risk of bad debts from accounts receivable, despite measures taken to manage credit risk [13]. - Inventory levels are high, and potential declines in market demand could lead to significant write-downs [14]. Group 6: Macro Environment Risks - Geopolitical tensions and international trade protectionism pose risks to the company's product sales and market access [15]. - The company relies on overseas suppliers for some raw materials, making it vulnerable to supply chain disruptions due to trade conflicts [16]. Group 7: Financial Performance Indicators - The company's net profit attributable to shareholders has shown a significant reduction in losses, with a decrease of 65.28% year-on-year [16]. - The basic earnings per share also reflect a similar trend, indicating improved financial management and cost reduction efforts [16]. Group 8: Core Competitiveness - The company has developed a comprehensive product matrix in gene sequencing, leveraging its proprietary DNBSEQ technology to enhance its market position [18][19]. - The focus on intelligent automation and AI-driven solutions is expected to drive innovation and operational efficiency in laboratory settings [21][23]. Group 9: Research and Development - R&D expenditures have increased, with a higher proportion of costs being capitalized compared to the previous year [30]. - The company is actively pursuing various R&D projects to enhance its technological capabilities and product offerings [30]. Group 10: Compliance and Governance - The company has established a robust system for managing and utilizing raised funds, ensuring compliance with regulatory requirements [32]. - There are no significant changes in the shareholding status of major stakeholders during the supervision period [34].

Core Insights - The company reported a revenue of 1.114 billion yuan for the first half of 2025, a year-on-year decline of 7.90%, with a net profit attributable to shareholders of -104 million yuan and a non-recurring net profit of -203 million yuan, indicating a reduction in losses [1] - The company has strategically upgraded its three main business segments to align with advancements in life sciences and AI, resulting in a revenue of 894 million yuan from the full-length sequencing segment, a decline of 12.15%, while the smart automation segment saw a slight increase of 0.39% to 112 million yuan, and the multi-omics segment grew by 40.01% to 85 million yuan [1] Business Performance - The sequencing business faced short-term pressure due to geopolitical factors, macroeconomic conditions, clinical transformation cycles, and price competition, with instrument revenue down 23.18% to 297.66 million yuan and reagent revenue down 6.30% to 554.56 million yuan [2] - Despite these challenges, the company achieved a historical high in sales of over 700 full-length sequencers, a year-on-year increase of 60.35%, with cumulative global sales exceeding 5,300 units in the first half of 2025 [2] Market Expansion - The company has expanded its overseas market presence by introducing 12 new distributors and establishing 30 DCS Lab laboratories, serving over 3,560 users [3] - In the domestic market, sequencer sales increased by 82.47% to over 600 units, with reaction counts exceeding 35,000, a growth of over 200% [3] - The Asia-Pacific region saw the addition of 22 new gene sequencing customers, while in Europe and Africa, 15 new CE certifications were obtained, and 22 new customers were added across several countries [3] Future Outlook - The company is expected to benefit from a global interest rate decline, increased research funding, and the release of demand for self-built sequencing platforms in hospitals, which may drive the industry back to double-digit growth [2] - The company maintains a strong competitive position as a leading domestic supplier of gene sequencers, with a positive outlook for overseas business growth [3]

Group 1: 华大智造 - 华大智造's Q1 2025 revenue decline is primarily due to seasonal fluctuations and market uncertainties, with expectations for revenue from platform replacement orders in Q2 [1] - Increased industry competition has led to a decline in average selling prices of core products, impacting gross margins; the company is implementing measures such as domestic material substitution and optimizing revenue structure to improve gross margins [1] - Revenue is expected to increase in Q4 2024, but losses are anticipated due to promotional discounts, increased new business contributions, and expense provisions, with cost logic still applicable due to scale effects [1] - The company is focused on cost reduction and efficiency improvement, optimizing budget management, organizational structure, and R&D projects, with significant reductions in expense ratios expected [1] - U.S. tariffs are affecting gross margins, with low overseas procurement ratios and reliance on imported components; domestic substitution is ongoing [1] - The company is preparing inventory to mitigate short-term impacts and is planning overseas factories for reagent supply, with limited effects from countermeasures [1] - There are 3,000 existing Illumina instruments, with 750 switch intentions received for high-performance alternatives provided by the company [1] - In reagent consumables, AI technology is being leveraged to optimize enzymes, enhancing sequencing speed and quality, and developing energy-efficient transportation methods [1] - The overseas commercialization strategy is tailored to local markets, focusing on mature markets in Europe and the U.S., while also paying attention to Asia-Pacific and emerging markets [1] - Domestically, the company is advancing NIPT upgrades, infectious disease testing, cancer early screening, rare disease detection, and innovations in the research field [1] Group 2: ST华通 - ST华通 is focusing on evergreen game categories such as SLG and match-3 games, emphasizing innovation and scalability [2] - The company believes that the future trend for SLG games is promising due to their ease of operation and strong user engagement, although successful teams are limited [2] - 盛趣游戏 plans to return to traditional advantages through cost reduction and efficiency improvements, exploring IP potential and seeking overseas markets [2] - Regarding the "Apple tax," the company sees the breaking of Apple payment restrictions as beneficial, though the short-term impact is expected to be minimal [2] - The company is providing competitive bonuses for team incentives, with the business team in a positive cycle [2] - ST华通 is optimistic about the long-term development of AI games, hosting innovation competitions while remaining cautious in the short term [2] - The company aims to leverage classic IP potential, relying on core users to launch new works [2]