Core Viewpoint - The planned 500 million yuan private placement by Guanhao Biotech has been officially terminated after more than two years of planning due to changes in the market environment and considerations of the company's overall development strategy [2][6]. Group 1: Private Placement Details - The private placement was initially approved by the shareholders in April 2023, but the company delayed the implementation multiple times, extending the validity of the resolution [3]. - In January 2024, Guanhao Biotech submitted the application to the Shenzhen Stock Exchange, which was accepted, but the company again extended the resolution's validity in March 2024 [4]. - The termination of the private placement comes after the company had planned to issue up to 55,803,571 shares at a price of 8.96 yuan per share, while the current stock price is 16.41 yuan per share, representing an increase of over 80% [5]. Group 2: Financial Implications - The company has a funding gap of 623 million yuan, which includes minimum cash reserves, repayment of short-term loans, and future large expenditures [6]. - As of the first quarter of 2024, Guanhao Biotech reported cash holdings of 122 million yuan against current liabilities of 146 million yuan [7]. Group 3: Business Performance - Guanhao Biotech's revenue dropped significantly by 22.84% in 2022 to 377 million yuan, with a net loss of 308 million yuan, but there was a recovery in 2023 [8]. - However, in 2024, both revenue and net profit are projected to decline again, with revenue decreasing by 6.60% to 377 million yuan and net profit down by 11.57% to 27.42 million yuan [8]. - The decline in revenue is attributed to decreased income from core products, particularly in the medical device and pharmaceutical sectors [8]. Group 4: Strategic Focus - Guanhao Biotech is shifting its focus towards the cell therapy sector, having established a research and application platform for cell and stem cell technology since 2013 [9]. - The company is currently developing projects in the cell field, including a bioartificial liver and mesenchymal stem cell therapy, both of which are in preclinical research [9]. - The termination of the private placement raises concerns about the viability of the company's "cell strategy," especially as R&D expenditures have been declining for three consecutive years [9].

4月22日晚间，冠昊生物（300238）(300238.SZ)披露2024年年度报告及2025年一季报。在行业变革等因 素影响下，2024年公司收入利润同比小幅下滑，营业收入实现3.77亿元，归母净利润2741.69万元。至 2025年一季度，公司收入利润恢复正增长，营业收入同比增长3.67%，实现9479.71万元，归母净利润同 比增长3.30%，实现1486.61万元，经营状况有所改善。 更值得一提的是公司在干细胞领域的布局。近年来，细胞行业在全球范围内持续蓬勃发展，展现出巨大 的潜力与活力。国内方面，尤其在2024年，国家药监局药审中心相继发布多项文件，如《免疫细胞治疗 产品临床试验技术指导原则(试行)》《人源干细胞产品药学研究与评价技术指导原则(试行)》等，从监 管政策层面为细胞治疗产业化明晰方向，规范细胞产品的药学研发与临床试验流程。政策环境的优化， 为细胞创新技术和产品的转化落地创造了有利条件。 此外，年报披露，公司在研的生物人工肝项目，目前正推进细胞药物的药学研究和体外支持装置等第三 类医疗器械性能研究工作，公司正积极与相关医院等多方合作申请开展临床前研究。若相关研发后续顺 利实现商业化，或将为 ...