Core Viewpoint - The article commemorates the 60th anniversary of the first artificial synthesis of bovine insulin in China, highlighting the enduring spirit of scientific innovation and the importance of passing this legacy to future generations of researchers [1][2]. Group 1: Historical Significance - The artificial synthesis of bovine insulin is regarded as a milestone in the journey to uncover the essence of life, marking a significant leap in the history of life sciences [1]. - The project began in December 1958, three years after the first determination of the primary structure of insulin, and faced immense challenges in a scientific "no man's land" [1]. Group 2: Scientific Spirit - The perseverance and dedication of the pioneering scientists, who worked under extremely challenging conditions, exemplified the spirit of innovation, rigor, and collaboration [2]. - The successful synthesis of crystalline bovine insulin in September 1965 represented the first instance of artificially creating a protein with the same chemical structure and biological activity as its natural counterpart [2]. Group 3: Call to Action - Current scientists are encouraged to learn from the insulin synthesis team, striving to reach new scientific heights and embrace their responsibilities in advancing national strategic technological capabilities [3]. - The emphasis is placed on integrating personal pursuits with national development goals, aiming for more original breakthroughs in technology [2][3].

Core Viewpoint - The 60th anniversary of the artificial total synthesis of crystalline bovine insulin is celebrated as a significant milestone in life sciences, marking a leap in understanding the essence of life and showcasing the innovative spirit of Chinese scientists [2][3]. Group 1: Historical Significance - The artificial total synthesis of crystalline bovine insulin is recognized as a milestone following the first artificial synthesis of an organic molecule, urea, in 1828, highlighting its eternal significance in the history of life sciences [2]. - The project was officially initiated in December 1958, three years after the first determination of the primary structure of insulin, under a national secret research program code-named "601," indicating it as the primary task of the 1960s [2]. Group 2: Scientific Achievement - In September 1965, a collaborative effort among the Chinese Academy of Sciences' Biochemistry Research Institute, the Organic Chemistry Research Institute, and Peking University led to the world's first artificial synthesis of a protein with the same chemical structure and complete biological activity as the natural molecule—crystalline bovine insulin [2][3]. Group 3: Inspirational Messages - The process of synthesizing artificial crystalline bovine insulin reflects the innovative confidence and scientific ambition of Chinese scientists to challenge the frontiers of life sciences [3]. - The event emphasized the connection between scientific exploration and revolutionary exploration, showcasing the shared spirit of great achievements in both fields [3]. Group 4: Call to Action - Current scientists are encouraged to learn from the team behind the artificial total synthesis of crystalline bovine insulin, aiming to reach new heights in technology and contribute significantly to the nation [5].

Core Viewpoint - The event commemorates the 60th anniversary of the artificial total synthesis of crystalline bovine insulin, highlighting its significance in the history of life sciences and the spirit of scientific exploration in China [1][3]. Group 1: Historical Significance - The artificial total synthesis of crystalline bovine insulin is considered a milestone in revealing the essence of life, following the first artificial synthesis of an organic molecule, urea, in 1828 [1][3]. - The project to synthesize insulin was officially established in December 1958, three years after the first determination of the primary structure of protein insulin, under a national secret research plan code-named "601" [3]. Group 2: Scientific Achievement - In September 1965, a collaboration among the Chinese Academy of Sciences' Biochemistry Research Institute, the Organic Chemistry Research Institute, and Peking University led to the world's first artificial synthesis of a protein with the same chemical structure and complete biological activity as the natural molecule—crystalline bovine insulin [3][5]. - This achievement is regarded as a model of cutting-edge research and remains one of the most significant scientific accomplishments of Chinese scientists today [5]. Group 3: Inspirational Messages - The event emphasized the need for contemporary scientists to learn from the insulin synthesis team, encouraging them to tackle challenging scientific frontiers with the same spirit of dedication and innovation [5][7]. - The connection between scientific exploration and revolutionary exploration was highlighted, showcasing the intertwined legacy of the great founding spirit of the Communist Party and the spirit of scientists [5].