分析师 1: 大家好，欢迎参加东北医药首席说脑机接口深度报告。现在有请主讲人开始发言，谢谢。 分析师 2: 好的，各位投资者晚上好，欢迎大家参加脑接口的这个行业深度报告。然后我们今天的这 个主要汇报的内容的话，主要有这个底下七个方面。然后实际上脑机接口这个赛道的话， 从今年年初，一直是属于非常热门的一个赛道话题。那么其实我们站在我们的角度的话， 我们理解脑机接口这个赛道的投资机会，它其实并不是一个情绪和主题催化的一个赛道， 它更多的话是反映的是一个产业的这个核心趋势。这个核心的产业趋势的话，一方面核心 的一个投资逻辑的话，也是跟我们看到的战略顶层的支持相关。 其实今天的话，也释放出了一个信号。就是我们国家最高领导人的话，在最新的这个科技 创新相关产业的视察过程中的话，也有相关脑机接口所在的一些研究院的领导出席。所以 脑科学战略的话，一直是属于非常，国家顶级的话，顶层非常关注的这样一个细分赛道。 那么整个脑机接口的话，我们从概念的领域，脑机接口我们可以把它划分成为这个按照它 这个脑电信号采集的这个位置的话，可以划分为这个侵入、半侵入和这个非侵入几大类。 然后这几大类的话，实际上的话，按照整个传感器的这个装，安装 ...

近日，国家药监局批准《采用脑机接口技术的医疗器械 范式设计与应用规范 运动功能重建》《采用脑 机接口技术的医疗器械 侵入式设备 可靠性验证方法》等2项医疗器械行业标准制修订项目立项，为采用 脑机接口技术的医疗器械高质量发展提供标准支撑。 脑机接口标准化建设传来新消息。 脑机接口是一种在脑与外部设备之间建立直接的通信渠道。常用于辅助、增强、修复人体的感觉—运动 功能或提升人机交互能力，目前在医学领域应用较为广泛。根据植入条件，脑机接口可分为侵入式、非 侵入式和半侵入式三种。 近年来，随着神经信号处理、生物兼容材料、高性能芯片等一系列核心技术接连突破，脑机接口得以快 速发展。与此同时，相关支持政策不断落地，标准化建设成为规范行业发展、保障产品安全有效的关键 抓手。 健康通副总裁、首席发展官张畅向21世纪经济报道记者表示，此次2项标准的立项是对工信部等七部门 此前发布的《关于推动脑机接口产业创新发展的实施意见》（简称《实施意见》）中标准体系建设相关 内容的具体落实，同时也结合行业反馈的共性难题实现了空白填补。由此，也为医疗领域开展相关研 究、临床试验等后续"专业步骤"，迈出了有章可循的关键第一步。 强化标准建设 脑 ...

21世纪经济报道记者闫硕 脑机接口标准化建设传来新消息。 近日，国家药监局批准《采用脑机接口技术的医疗器械范式设计与应用规范运动功能重建》《采用脑机接口技术的医疗器械侵入式设备可靠性 验证方法》等2项医疗器械行业标准制修订项目立项，为采用脑机接口技术的医疗器械高质量发展提供标准支撑。 脑机接口是一种在脑与外部设备之间建立直接的通信渠道。常用于辅助、增强、修复人体的感觉–运动功能或提升人机交互能力，目前在医学 领域应用较为广泛。根据植入条件，脑机接口可分为侵入式、非侵入式和半侵入式三种。 近年来，随着神经信号处理、生物兼容材料、高性能芯片等一系列核心技术接连突破，脑机接口得以快速发展。与此同时，相关支持政策不断 落地，标准化建设成为规范行业发展、保障产品安全有效的关键抓手。 健康通副总裁、首席发展官张畅向21世纪经济报道记者表示，此次2项标准的立项是对工信部等七部门此前发布的《关于推动脑机接口产业创 新发展的实施意见》（简称《实施意见》）中标准体系建设相关内容的具体落实，同时也结合行业反馈的共性难题实现了空白填补。由此，也 为医疗领域开展相关研究、临床试验等后续"专业步骤"，迈出了有章可循的关键第一步。 强化标 ...

Summary of Neural Interface Technology Conference Industry Overview - The conference focused on the neural interface technology industry, particularly advancements made by Neuralink and domestic companies in China [1][3][4][5][10]. Key Points and Arguments Neuralink's Advancements - Neuralink has significantly reduced the cost of implantable devices, with fixture costs dropping by 95%, from approximately $5,000-$6,000 to a few hundred dollars [1][3][4]. - The electrode production cost remains high, at over $10,000 per electrode, but the implantation speed has improved from 20 seconds to 1.5 seconds per electrode, facilitating clinical applications [1][3][4]. - The company has entered clinical trials, utilizing BlackRock electrodes and developing its own implantation devices that combine electron microscopy and OCR systems for precise electrode placement [1][8][9]. Challenges in Neural Interface Technology - The industry faces challenges such as complex electrode production processes, low yield rates, and patent barriers, particularly regarding non-invasive puncture techniques patented by Musk [1][5][6]. - Domestic companies need breakthroughs in materials, processes, and patent strategies to compete effectively [1][5]. Comparison of Invasive and Semi-Invasive Techniques - Neuralink's fully invasive technology targets complex diseases, while domestic companies like BoruiKang focus on semi-invasive methods primarily for rehabilitation, which are less risky and costly [1][7][10]. - The main difference lies in the application: fully invasive techniques aim to treat severe conditions through deep neural stimulation, whereas semi-invasive methods are used for rehabilitation by repairing damaged nerves [1][7]. Domestic Industry Landscape - Domestic companies such as JieTi, Tiger Technology, and WeiLing have made progress in flexible electrodes but still lag behind international leaders like Neuralink in terms of channel count (128 channels vs. Neuralink's 1,024 channels) and other technical specifications [1][10]. - The downstream applications of the domestic neural interface industry account for 70% of the market share, focusing on rehabilitation devices and commercial products, while upstream investments in electrode and chip development are capital-intensive [1][10]. Clinical Applications and Future Directions - BoruiKang's semi-quantitative methods have been widely adopted in over 20 hospitals in China, with more than 200 clinical trials conducted in 2024 [12]. - The potential for interventionist neural interfaces is highlighted, with successful trials indicating a promising future if challenges like vascular blockage can be addressed [2][16]. Competitive Landscape - Companies like Medtronic have received FDA approval for their brain stimulators, showing significant efficacy in treating conditions like epilepsy, while competitors like Pinchi Medical face challenges due to patent restrictions [14][25]. - The market for deep brain stimulation (DBS) devices is still developing, with no fully mature embedded products available yet [25]. Additional Important Insights - The domestic neural interface industry is characterized by a high investment threshold in the upstream sector, with a typical investment ratio of 3:1 or 4:1 favoring downstream applications [10]. - The technology's application in treating neurological diseases is expanding, with potential uses in conditions like Alzheimer's and depression through adaptive neural regulation [19]. This summary encapsulates the key discussions and insights from the neural interface technology conference, highlighting both advancements and challenges within the industry.

Core Insights - The medical technology industry in November shows signs of change amidst cautious capital and an incomplete market recovery, with increasing information density and directional trends emerging [1] Capital Movements - High-tech fields such as AI, neurology, and cardiovascular are gaining traction, with early-stage financing showing signs of recovery [2][3] - Notable financing cases include over 50 million for a neuromedical technology company and nearly 1 billion for a slow obstructive lung disease treatment [4][9] - Investment interest is shifting towards under-served treatment areas like respiratory chronic diseases and minimally invasive gynecology [2][3] IPO Progress - IPO activity is showing clear differentiation under the pressure of centralized procurement, with companies that can cross the "profit verification line" continuing to advance [5][6] Policy and Regulation - November saw two key trends in policy: a multi-department push for medical device innovation and accelerated entry of domestic materials into regional procurement systems [6][11] New Product Approvals - The approval of AI monitoring and closed-loop brain pacemakers indicates a clear focus on technologies that enhance diagnostic and treatment efficiency [7][12] Exhibitions - Major exhibitions in November highlighted trends in robotic surgery and the integration of domestic innovations into clinical practice [13] Strategic Movements - November marked a significant surge in acquisition activity, with notable deals ranging from 3.3 billion to 149.3 billion, indicating a strategic repositioning among major players [16][18] - The industry is witnessing a structural shift towards "thousand-billion and hundred-billion" level acquisitions, reflecting a broader trend of consolidation and strategic realignment [16] Structural Signals - The integration of robotics, imaging, and materials into a "smart" ecosystem is becoming a consensus in the industry, as evidenced by the exhibitions [17]

Core Insights - The "14th Five-Year Plan" has led to significant growth in China's high-tech industries, with the added value of large-scale high-tech manufacturing increasing by 42% compared to the end of the "13th Five-Year Plan" [2] - The contribution of the "three new" economies to GDP has reached 18%, with emerging sectors like artificial intelligence and biotechnology becoming new growth points [2] Group 1: Traditional Industry Transformation - China is accelerating key technology breakthroughs in high-end equipment and advanced manufacturing, promoting the transformation of traditional industries towards high-end, intelligent, and green development [3] - The "Jinghua" super-large diameter shield machine has set a new record by tunneling 542 meters in a month, with a diameter exceeding 16 meters and no disturbance to surface buildings [3] - The "Dream" deep-sea drilling vessel, China's first independently designed and built deep-sea drilling ship, can reach depths of 11,000 meters, showcasing global technological leadership [3] - Artificial intelligence, IoT, and big data are revolutionizing factories, with China having the highest number of "lighthouse factories" globally, accounting for 40% of the total [3] Group 2: Emerging Industry Development - Continuous integration of technology and industry has led to significant breakthroughs in new-generation information technology and renewable energy, driving the growth of emerging industries [4] - Approximately 4.6 million 5G base stations have been built in China, leading the world in both technology and user numbers [4] - The cumulative sales of new energy vehicles in China have surpassed 40 million, maintaining the global lead for ten consecutive years, with 2024 sales projected to be 9.5 times that of 2020 [4] Group 3: Future Industry Foundations - China is proactively investing in cutting-edge fields such as artificial intelligence and brain-computer interfaces to gain a competitive edge in future industries [6] - Over 1,500 large models in artificial intelligence have been released, with many achieving advanced global standards and accuracy rates exceeding 95% [7] - Brain-computer interface technology has significantly improved the quality of life for patients, with domestic brain pacemakers now in use in 400 hospitals across eight countries [7] Group 4: Strategic Vision - The focus on technological innovation is seen as a core element in developing new productive forces and building a modern industrial system, which is crucial for overall economic development [7] - The achievements during the "14th Five-Year Plan" period highlight the importance of technological innovation in driving high-quality development [7] - Looking ahead to the "15th Five-Year Plan," the emphasis on integrating technological and industrial innovation is expected to continue fueling robust economic growth [7]

Group 1: Achievements in Technology Innovation - During the "14th Five-Year Plan" period, China's technological innovation capabilities have steadily improved, with a solid foundation for becoming a technology powerhouse [1] - By 2024, China's total R&D investment is expected to exceed 3.6 trillion yuan, a 48% increase from 2020, with an R&D intensity of 2.68%, surpassing the EU average [1] - The total number of R&D personnel in China ranks first in the world, and basic research funding is projected to reach 249.7 billion yuan in 2024, a growth of over 70% from 2020 [1] Group 2: Industrial Transformation and Upgrading - The Ministry of Science and Technology emphasizes that technological and industrial innovation are essential paths for developing new productive forces [2] - Key technological breakthroughs in high-end equipment and advanced manufacturing are being pursued to facilitate the transformation of traditional industries towards high-end, intelligent, and green development [2] - The "Jinghua" shield machine has set a record of 542 meters of excavation in a month, and the domestically designed "Dream" deep-sea drilling vessel has been successfully launched, capable of drilling to depths of 11,000 meters [2] Group 3: Development of Emerging Industries - China is deepening the integration of technology and industry, achieving significant breakthroughs in new generation information technology and renewable energy [3] - Approximately 4.6 million 5G base stations have been built, maintaining global leadership in technology and user numbers [3] - Cumulative sales of new energy vehicles have surpassed 40 million, with production and sales leading the world for ten consecutive years [3] Group 4: Systematic Layout for Breakthrough Achievements - The Ministry of Science and Technology has set systematic goals for achieving a better environment, food security, faster transportation, and improved health [4] - Significant progress has been made in environmental pollution prevention, with PM2.5 concentrations in the Beijing-Tianjin-Hebei region decreasing by 18% [5] - The CR450 train can reach operational speeds of 400 km/h, and the C919 aircraft has received over 1,000 domestic and international orders [6] Group 5: Health Innovations - The focus on health has led to the development of advanced medical equipment and new drug creation, including the world's first 5.0T full-body MRI scanner [7] - A dual-antibody drug for solid tumors has been approved and included in the national medical insurance directory, providing new treatment options for cervical cancer patients [7]

Core Viewpoint - The article highlights the achievements in technological innovation during the "14th Five-Year Plan" period, emphasizing the role of technology in driving new productive forces and the application of key core technologies in various fields [1]. Group 1: Technological Achievements - Significant breakthroughs have been made in humanoid robotics, with advancements in whole machine technology, multi-modal perception, and brain-cerebellum models, facilitating deep integration with embodied intelligence [1]. - The application of humanoid robots is accelerating in industries such as automotive manufacturing, logistics handling, and power inspection, laying a solid foundation for the future trillion-level industry [1]. Group 2: Brain-Computer Interface Developments - The brain-computer interface field has seen advancements that assist paraplegic patients in standing and walking, and help blind individuals regain light perception [1]. - Domestic brain stimulators have achieved full commercialization, with implantation conducted in 400 hospitals across 8 countries, benefiting 30,000 Parkinson's disease patients by improving motor functions [1].

Group 1 - The core viewpoint of the article emphasizes the achievements in technological innovation during the "14th Five-Year Plan" period, highlighting the role of technology in driving new quality productivity [1] - The Ministry of Science and Technology has focused on key core technology breakthroughs and application of results to lead the development of new quality productivity [1] Group 2 - Traditional industries are being empowered for transformation and upgrading, with advancements in high-end equipment and manufacturing technologies leading to higher quality and efficiency [1] - The "Jinghua" 16.07-meter ultra-large diameter shield machine set a new record of 542 meters of excavation in a month and has been successfully applied in projects without disturbing surface buildings [1] - The first domestically designed and built "Dream" deep-sea drilling ship has been officially launched, with an internationally leading drilling system capable of reaching depths of 11,000 meters [1] Group 3 - Emerging industries are experiencing significant growth, with major technological breakthroughs in new generation information technology and renewable energy [2] - Approximately 4.6 million 5G base stations have been built in China, maintaining global leadership in technology and user numbers, facilitating digital upgrades across various industries [2] - Cumulative sales of new energy vehicles in China have surpassed 40 million, maintaining the world's highest production and sales for ten consecutive years, contributing to global carbon reduction goals [2] Group 4 - Future industries are being solidified through advanced layouts in artificial intelligence and brain-computer interfaces, creating new advantages [3] - Multiple general models in artificial intelligence have emerged, with some achieving accuracy rates exceeding 95%, leading to over a hundred benchmark application scenarios [3] - The domestic brain pacemaker has been fully commercialized, helping 30,000 Parkinson's disease patients improve motor functions across 400 hospitals in eight countries [3]

Group 1 - The core viewpoint emphasizes the importance of technological innovation in driving high-quality development during the "14th Five-Year Plan" period in China [1] - The country has made significant advancements in key core technologies and their applications, leading to positive outcomes in various sectors [1] Group 2 - In the high-end equipment sector, China has developed the "Jinghua" 16.07-meter ultra-large diameter shield tunneling machine and the first domestically designed and built "Dream" deep-sea drilling vessel [2] - In advanced manufacturing, technologies such as artificial intelligence, the Internet of Things, and big data are facilitating the transition from traditional manufacturing to intelligent manufacturing, with China having the largest number of "lighthouse factories" globally, accounting for over 40% [2] - Approximately 4.6 million 5G base stations have been established in China, maintaining a global lead in technology and user numbers, which supports digital upgrades across various industries [2] - In the renewable energy sector, China has continuously broken world records for the efficiency of photovoltaic silicon batteries, with new installations of solar and wind power exceeding 100 million kilowatts for four consecutive years; cumulative sales of new energy vehicles have surpassed 40 million, maintaining the world's highest production and sales for ten consecutive years [2] Group 3 - China is proactively laying out plans for future industries, focusing on cutting-edge technologies such as artificial intelligence and brain-computer interfaces to create new advantages [3] - In the field of artificial intelligence, several domestic general models have reached internationally advanced levels, with some achieving accuracy rates exceeding 95%, leading to the development of over a hundred benchmark application scenarios [3] - Breakthroughs in humanoid robot technology, including multi-modal perception and brain-cerebellum models, are accelerating the application of humanoid robots in sectors like automotive manufacturing, logistics, and power inspection, laying a solid foundation for the development of a trillion-dollar industry [3] - The brain-computer interface technology has enabled paraplegic patients to stand and walk, and blind individuals to regain light perception; domestically produced brain stimulators are now fully commercialized, helping 30,000 Parkinson's disease patients improve motor functions across 400 hospitals in eight countries [3]