Core Viewpoint - Haofan Bio, a leader in the domestic peptide synthesis reagent sector, has shown significant growth and is well-positioned to capitalize on the expanding global biopharmaceutical market, particularly in peptide drugs [2][6]. Financial Performance - In the first half of 2025, Haofan Bio reported a revenue of 270 million yuan, representing a year-on-year growth of 20.1%, and a net profit attributable to shareholders of 75.88 million yuan, up 15.3% year-on-year [2]. R&D and Capacity Upgrades - Following its listing on the ChiNext board in 2023, Haofan Bio has accelerated its dual upgrades in R&D and production capacity, with a 30% increase in R&D personnel and the construction of three production bases to alleviate capacity constraints [3][6]. - The company has also established a new R&D building and introduced advanced research and testing equipment [3]. Technology and Product Development - Haofan Bio has developed a comprehensive range of peptide synthesis reagents, from the first to the fourth generation, becoming one of the few global manufacturers to cover the entire series [4][5]. - The company is actively expanding its product system to include general molecular building blocks and pharmaceutical reagents for liposomes and lipid nanoparticles, with over 120 types of these reagents in small-scale research and some entering small batch production [5]. Market Opportunities and Challenges - The global peptide drug market is expected to exceed $100 billion by 2027, presenting significant opportunities for Haofan Bio, although capacity shortages remain a critical issue [6]. - The company plans to address this by acquiring Foster Pharmaceutical for 160 million yuan, which will provide additional production capacity and facilitate the transition of new products from small-scale trials to mass production [6]. Strategic Focus - Haofan Bio emphasizes a strategy of solidifying its core product quality and maintaining market position while providing comprehensive support to clients throughout their development stages [7]. - The company aims to avoid blind pursuit of trends and instead focus on steady innovation to serve the global market effectively [7].

Core Insights - The article highlights the growth and strategic direction of Haofan Bio, a leader in the peptide synthesis reagent sector, emphasizing its commitment to innovation and market stability in the global biopharmaceutical landscape [2][3][4]. Financial Performance - In the first half of 2025, Haofan Bio reported a revenue of 270 million yuan, representing a year-on-year increase of 20.1%, and a net profit attributable to shareholders of 75.88 million yuan, up 15.3% year-on-year [2]. Market Position and Strategy - Haofan Bio has been deeply engaged in the peptide synthesis reagent market for over 20 years, successfully developing first to fourth generation reagents, which positions the company as one of the few global manufacturers covering the entire series [2][4]. - The company aims to build a technological "moat" in the peptide sector, focusing on high-quality products and maintaining its market position through steady innovation [2][4]. R&D and Capacity Expansion - Following its listing on the ChiNext board in 2023, Haofan Bio has accelerated its R&D and production capacity upgrades, including the construction of a new R&D building and the introduction of advanced equipment, increasing its R&D personnel by 30% [3][6]. - The company is also expanding its production bases to alleviate capacity constraints, with plans to establish 3 to 5 workshops at its Huai'an production base by next year [6]. Acquisition Strategy - A key part of Haofan Bio's strategy to address capacity issues includes the planned acquisition of Hangzhou Foster Pharmaceutical for 160 million yuan, which will provide additional production capacity and facilitate the transition of new products from small-scale to larger-scale production [6][7]. Future Outlook - The global peptide drug market is expected to exceed 100 billion USD by 2027, presenting significant growth opportunities for Haofan Bio, although the company acknowledges the challenges posed by rapid changes in pharmaceutical demand [6][7]. - The company emphasizes a cautious approach to future expansions, preferring to focus on solidifying its core product quality and maintaining a stable market position rather than pursuing aggressive acquisitions [6][7].

Group 1 - The core viewpoint of the news is that Haofan Bio experienced a decline in stock price and trading volume, with significant financing and margin trading activities indicating high investor interest and potential volatility [1][2][3] Group 2 - As of September 23, Haofan Bio's stock price fell by 2.15%, with a trading volume of 120 million yuan. The net financing buy was -3.15 million yuan, indicating more selling than buying on that day [1] - The financing balance for Haofan Bio reached 144 million yuan, accounting for 5.21% of its market capitalization, which is above the 80th percentile of the past year, suggesting a high level of leverage [1] - On the same day, Haofan Bio had a margin trading balance of 448,400 yuan, with a margin sell of 500 shares, indicating a relatively high level of short selling activity [1] Group 3 - As of June 30, Haofan Bio had 11,400 shareholders, an increase of 7.24% from the previous period, while the average number of circulating shares per shareholder decreased by 6.75% [2] - For the first half of 2025, Haofan Bio reported a revenue of 270 million yuan, representing a year-on-year growth of 20.10%, and a net profit of 75.88 million yuan, up 15.31% year-on-year [2] Group 4 - Since its A-share listing, Haofan Bio has distributed a total of 95.54 million yuan in dividends [3] - As of June 30, 2025, the sixth largest circulating shareholder of Haofan Bio is Huatai-PineBridge Healthcare Mixed Fund, holding 602,500 shares as a new shareholder, while two other funds exited the top ten list [3]

Investment Rating - The report assigns a "Buy" rating for the company, indicating that the stock price is expected to outperform the benchmark index by more than 15% [13]. Core Insights - The company's main business of peptide synthesis reagents shows steady growth, with a significant contribution from overseas markets [2][4]. - In 2024, the company achieved a revenue of 452 million yuan, a year-on-year increase of 16.22%, and a net profit attributable to the parent company of 134 million yuan, up 35.44% year-on-year [1]. - The company has a robust product reserve and customer base, which helps in building a competitive moat [4][5]. Financial Performance - In 2024, the sales of peptide synthesis reagents amounted to 354 million yuan, a year-on-year increase of 17.42%, while the sales of general molecular building blocks decreased by 22.02% to 58 million yuan [2]. - The company's gross margin for 2024 was 40.28%, an increase of 1.73 percentage points year-on-year, with the gross margin for peptide synthesis reagents at 41.55%, up 3.04 percentage points [3]. - The company expects revenues of 581 million yuan, 723 million yuan, and 871 million yuan for 2025, 2026, and 2027 respectively, with net profits projected at 173 million yuan, 216 million yuan, and 260 million yuan for the same years [7]. Product and Market Position - The company has developed over 160 types of novel peptide synthesis reagents and has a comprehensive product system with more than 800 types of general molecular building blocks [4]. - The company serves over 1,900 pharmaceutical R&D and production enterprises, with a significant increase in procurement from CDMO clients in 2024 [5]. - The company’s self-built production capacity is expected to enhance its production capabilities, with a project in Anhui expected to produce 1,002 tons of peptide reagents annually [5].

股票简称：昊帆生物 股票代码：301393 首次公开发行股票并在创业板上市 之 上市公告书 保荐人（主承销商） 苏州昊帆生物股份有限公司 Suzhou Highfine Biotech Co., Ltd. （苏州高新区鸿禧路 32 号 F-12 标准厂房） （中国（上海）自由贸易试验区浦明路 8 号） 二零二三年七月 特别提示 苏州昊帆生物股份有限公司（以下简称"昊帆生物"、"本公司"或"发行 人"、"公司"）股票将于 2023 年 7 月 12 日在深圳证券交易所创业板上市，该 市场具有较高的投资风险。创业板公司具有业绩不稳定、经营风险高、退市风险 大等特点，投资者面临较大的市场风险。投资者应充分了解创业板市场的投资风 险及本公司所披露的风险因素，审慎做出投资决定。 本公司提醒投资者应充分了解股票市场风险以及本公司披露的风险因素，在 新股上市初期切忌盲目跟风"炒新"，应当审慎决策、理性投资。 如无特别说明，本上市公告书中的简称或名词的释义与本公司首次公开发行 股票并在创业板上市招股说明书中的相同。 1 | 特别提示 1 | | | --- | --- | | 目 录 2 | | | 第一节 重要声明与提示 ...

本次发行股票拟在创业板上市，创业板公司具有创新投入大、新旧产业融合 存在不确定性、尚处于成长期、经营风险高、业绩不稳定、退市风险高等特 点，投资者面临较大的市场风险。投资者应充分了解创业板的投资风险及本 公司所披露的风险因素，审慎作出投资决定。 苏州昊帆生物股份有限公司 Suzhou Highfine Biotech Co., Ltd. （苏州高新区鸿禧路 32 号 F-12 标准厂房） 首次公开发行股票并在创业板上市 招股说明书 保荐人（主承销商） （中国（上海）自由贸易试验区浦明路 8 号） 苏州昊帆生物股份有限公司 招股说明书 声明 中国证监会、交易所对本次发行所作的任何决定或意见，均不表明其对发行 人注册申请文件及所披露信息的真实性、准确性、完整性作出保证，也不表明其 对发行人的盈利能力、投资价值或者对投资者的收益作出实质性判断或保证。任 何与之相反的声明均属虚假不实陈述。 根据《证券法》的规定，股票依法发行后，发行人经营与收益的变化，由发 行人自行负责；投资者自主判断发行人的投资价值，自主作出投资决策，自行承 担股票依法发行后因发行人经营与收益变化或者股票价格变动引致的投资风险。 1-1-1 苏州昊 ...

苏州昊帆生物股份有限公司 首次公开发行股票并在创业板上市发行公告 保荐人（主承销商）： 特别提示 苏州昊帆生物股份有限公司（以下简称"昊帆生物"、"发行人"或"公司"）根据中 国证券监督管理委员会（以下简称"中国证监会"）《证券发行与承销管理办法》（证 监会令[第 208 号]）（以下简称"《管理办法》"）、《首次公开发行股票注册管理办 法》（证监会令[第 205 号]）、深圳证券交易所（以下简称"深交所"）《深圳证券交 易所首次公开发行证券发行与承销业务实施细则》（深证上[2023]100 号）（以下简 称"《实施细则》"）、《深圳市场首次公开发行股票网上发行实施细则》（深证上 〔2018〕279 号）（以下简称"《网上发行实施细则》"）、《深圳市场首次公开发行 股票网下发行实施细则（2023 年修订）》（深证上〔2023〕110 号）（以下简称"《网 下发行实施细则》"）、《深圳证券交易所创业板投资者适当性管理实施办法（2020 年修订》（以下简称"《投资者适当性管理办法》"）和中国证券业协会（以下简 称"证券业协会"）《首次公开发行证券承销业务规则》（中证协发〔2023〕18 号）、 《首次公开发行证券 ...

苏州昊帆生物股份有限公司 Suzhou Highfine Biotech Co., Ltd. （苏州高新区鸿禧路 32 号 F-12 标准厂房） 首次公开发行股票并在创业板上市 本次发行股票拟在创业板上市，创业板公司具有创新投入大、新旧产业融合 存在不确定性、尚处于成长期、经营风险高、业绩不稳定、退市风险高等特 点，投资者面临较大的市场风险。投资者应充分了解创业板的投资风险及本 公司所披露的风险因素，审慎作出投资决定。 招股意向书 保荐人（主承销商） （中国（上海）自由贸易试验区浦明路 8 号） 苏州昊帆生物股份有限公司 招股意向书 声明 中国证监会、交易所对本次发行所作的任何决定或意见，均不表明其对发行 人注册申请文件及所披露信息的真实性、准确性、完整性作出保证，也不表明其 对发行人的盈利能力、投资价值或者对投资者的收益作出实质性判断或保证。任 何与之相反的声明均属虚假不实陈述。 根据《证券法》的规定，股票依法发行后，发行人经营与收益的变化，由发 行人自行负责；投资者自主判断发行人的投资价值，自主作出投资决策，自行承 担股票依法发行后因发行人经营与收益变化或者股票价格变动引致的投资风险。 1-1-1 苏州昊 ...

本次发行股票拟在创业板上市，创业板公司具有创新投入大、新旧产业融合 存在不确定性、尚处于成长期、经营风险高、业绩不稳定、退市风险高等特 点，投资者面临较大的市场风险。投资者应充分了解创业板的投资风险及本 公司所披露的风险因素，审慎作出投资决定。 苏州昊帆生物股份有限公司 Suzhou Highfine Biotech Co., Ltd. （苏州高新区鸿禧路 32 号 F-12 标准厂房） 首次公开发行股票并在创业板上市 招股说明书 （注册稿） 本公司的发行申请尚需经深圳证券交易所和中国证监会履行相应程序。本招 股说明书不具有据以发行股票的法律效力，仅供预先披露之用。投资者应当 以正式公告的招股说明书作为投资决定的依据。 保荐人（主承销商） （中国（上海）自由贸易试验区浦明路 8 号） 苏州昊帆生物股份有限公司 招股说明书 声明 中国证监会、交易所对本次发行所作的任何决定或意见，均不表明其对发行 人注册申请文件及所披露信息的真实性、准确性、完整性作出保证，也不表明其 对发行人的盈利能力、投资价值或者对投资者的收益作出实质性判断或保证。任 何与之相反的声明均属虚假不实陈述。 根据《证券法》的规定，股票依法发行后， ...

本次发行股票拟在创业板上市，创业板公司具有创新投入大、新旧产业融合 存在不确定性、尚处于成长期、经营风险高、业绩不稳定、退市风险高等特 点，投资者面临较大的市场风险。投资者应充分了解创业板的投资风险及本 公司所披露的风险因素，审慎作出投资决定。 苏州昊帆生物股份有限公司 Suzhou Highfine Biotech Co., Ltd. （苏州高新区鸿禧路 32 号 F-12 标准厂房） 首次公开发行股票并在创业板上市 招股说明书 （注册稿） 本公司的发行申请尚需经深圳证券交易所和中国证监会履行相应程序。本招 股说明书不具有据以发行股票的法律效力，仅供预先披露之用。投资者应当 以正式公告的招股说明书作为投资决定的依据。 保荐人（主承销商） （中国（上海）自由贸易试验区浦明路 8 号） 苏州昊帆生物股份有限公司 招股说明书 重要声明与承诺 中国证监会、交易所对本次发行所作的任何决定或意见，均不表明其对注册 申请文件及所披露信息的真实性、准确性、完整性作出保证，也不表明其对发行 人的盈利能力、投资价值或者对投资者的收益作出实质性判断或保证。任何与之 相反的声明均属虚假不实陈述。 根据《证券法》的规定，股票依法发行 ...