证券日报网讯昊帆生物（301393）11月18日在互动平台回答投资者提问时表示，根据已披露的2024年 报，公司2024年度直接销往亚洲、欧洲、美洲的境外销售收入占公司营业收入总额的比例分别为 22.13%、10.04%、4.09%。公司主要产品是以多肽合成试剂为主的特色化学原料，处于医药产业链的上 游位置，产品种类丰富，用途广泛，每年服务的客户达上千家，具有较强的抗风险能力。但若后续医药 行业整体情况发生重大变化，或是下游主要客户情况发生重大变化，公司亦有可能受到间接影响，请投 资者注意投资风险。此外，公司于2025年1月在德国注册成立了全资子公司，主要面向欧洲市场的 CDMO和制剂类客户，以求进一步开拓欧洲市场业务，抓住市场机遇。 ...

（文章来源：证券日报） 证券日报网讯昊帆生物11月18日在互动平台回答投资者提问时表示，公司服务众多医药研发与生产企 业，为下游客户提供以多肽合成试剂和分子砌块为主的各类特色化学试剂。 ...

Core Insights - The peptide synthesis reagent industry is experiencing rapid growth driven by the expanding global peptide drug market, which is projected to reach $110.7 billion in 2024 and $121.7 billion in 2025, with the U.S. holding a dominant share and China showing significant potential [1][6][8] - China's peptide drug market is expected to grow from approximately 55.44 billion yuan in 2024 to 61.2 billion yuan in 2025, providing a solid demand foundation for upstream reagent industries [1][8] - The Chinese peptide synthesis reagent market is projected to grow from about 2.44 billion yuan in 2024 to 2.68 billion yuan in 2025, with strong growth in the ion-type condensation reagent segment [1][9] Industry Overview - Peptide synthesis reagents are specialized chemical agents that facilitate the formation of peptide bonds between amino acids, protect active groups, and suppress side reactions, making them essential in peptide drug development and biomedical research [2][3] - The industry is transitioning from traditional fermentation and extraction methods to chemical synthesis and gene recombination methods, which now dominate the market [5][6] Market Dynamics - The global peptide drug market is expanding due to advancements in synthesis and modification technologies, with a notable increase in demand for innovative therapies targeting chronic diseases [6][8] - In China, the rapid development of the peptide drug market is supported by policy initiatives, clinical demand, and technological advancements, with a projected market size of approximately 554.4 billion yuan in 2024 [8][9] Competitive Landscape - The Chinese peptide synthesis reagent industry features a fragmented competitive landscape with a mix of specialized and comprehensive companies, where most focus on specific types of reagents [10][11] - Leading companies like Haofan Bio are establishing a strong position by offering a full range of peptide synthesis reagents, while other firms focus on niche markets [11][12] Development Trends - The industry is moving towards technological innovation, with a focus on green and efficient synthesis methods, and a shift from single-function to multifunctional reagents [12][13] - Domestic companies are increasingly penetrating high-end markets, breaking the monopoly of international brands in high-purity and low racemization reagents [13][14] - The competitive landscape is evolving from fragmented product competition to an ecosystem of collaborative competition, with leading firms building comprehensive product matrices and enhancing vertical integration [14]

Core Viewpoint - Haofan Bio, a leading company in the peptide synthesis reagent sector, was established in December 2003 and went public on July 12, 2023, in Shenzhen, with its headquarters in Suzhou, Jiangsu Province [1] Group 1: Business Overview - Haofan Bio specializes in the research and sales of peptide synthesis reagents, protein crosslinkers, and molecular building blocks, with a focus on peptide drugs, innovative drugs, and biopharmaceuticals [1] - The company has a differentiated advantage in technology and customer resources [1] Group 2: Financial Performance - In Q3 2025, Haofan Bio reported revenue of 435 million yuan, ranking 24th among 34 companies in the industry, while the industry leader, Changchun High-tech, had revenue of 9.807 billion yuan [2] - The net profit for the same period was approximately 99.24 million yuan, placing the company 16th in the industry, with the top performer, Tonghua Dongbao, reporting a net profit of 1.188 billion yuan [2] Group 3: Financial Ratios - As of Q3 2025, Haofan Bio's debt-to-asset ratio was 7.86%, significantly lower than the industry average of 26.88%, indicating strong solvency [3] - The company's gross profit margin was 38.75%, which is below the industry average of 70.17%, suggesting room for improvement in profitability [3] Group 4: Shareholder Information - As of September 30, 2025, the number of A-share shareholders decreased by 12.14% to 10,000, while the average number of circulating A-shares held per shareholder increased by 19.09% to 4,200.4 [5] - The fifth largest circulating shareholder, Huatai-PB Health Mixed Fund, increased its holdings by 26,430 shares [5] Group 5: Future Outlook - The company is expected to maintain steady growth, with projected net profits of 166 million, 208 million, and 268 million yuan for 2025 to 2027, respectively, and corresponding EPS of 1.54, 1.93, and 2.48 yuan [5] - Haofan Bio has established a presence in over 1,900 pharmaceutical-related enterprises globally and is actively expanding into the European market [5] - The company is enhancing its production capacity through self-built facilities and acquisitions, with ongoing projects in Anhui and Huai'an expected to resolve capacity issues by mid-2026 [5]

Core Viewpoint - Haofan Bio, a leader in the domestic peptide synthesis reagent sector, has shown significant growth and is well-positioned to capitalize on the expanding global biopharmaceutical market, particularly in peptide drugs [2][6]. Financial Performance - In the first half of 2025, Haofan Bio reported a revenue of 270 million yuan, representing a year-on-year growth of 20.1%, and a net profit attributable to shareholders of 75.88 million yuan, up 15.3% year-on-year [2]. R&D and Capacity Upgrades - Following its listing on the ChiNext board in 2023, Haofan Bio has accelerated its dual upgrades in R&D and production capacity, with a 30% increase in R&D personnel and the construction of three production bases to alleviate capacity constraints [3][6]. - The company has also established a new R&D building and introduced advanced research and testing equipment [3]. Technology and Product Development - Haofan Bio has developed a comprehensive range of peptide synthesis reagents, from the first to the fourth generation, becoming one of the few global manufacturers to cover the entire series [4][5]. - The company is actively expanding its product system to include general molecular building blocks and pharmaceutical reagents for liposomes and lipid nanoparticles, with over 120 types of these reagents in small-scale research and some entering small batch production [5]. Market Opportunities and Challenges - The global peptide drug market is expected to exceed $100 billion by 2027, presenting significant opportunities for Haofan Bio, although capacity shortages remain a critical issue [6]. - The company plans to address this by acquiring Foster Pharmaceutical for 160 million yuan, which will provide additional production capacity and facilitate the transition of new products from small-scale trials to mass production [6]. Strategic Focus - Haofan Bio emphasizes a strategy of solidifying its core product quality and maintaining market position while providing comprehensive support to clients throughout their development stages [7]. - The company aims to avoid blind pursuit of trends and instead focus on steady innovation to serve the global market effectively [7].

Core Insights - The article highlights the growth and strategic direction of Haofan Bio, a leader in the peptide synthesis reagent sector, emphasizing its commitment to innovation and market stability in the global biopharmaceutical landscape [2][3][4]. Financial Performance - In the first half of 2025, Haofan Bio reported a revenue of 270 million yuan, representing a year-on-year increase of 20.1%, and a net profit attributable to shareholders of 75.88 million yuan, up 15.3% year-on-year [2]. Market Position and Strategy - Haofan Bio has been deeply engaged in the peptide synthesis reagent market for over 20 years, successfully developing first to fourth generation reagents, which positions the company as one of the few global manufacturers covering the entire series [2][4]. - The company aims to build a technological "moat" in the peptide sector, focusing on high-quality products and maintaining its market position through steady innovation [2][4]. R&D and Capacity Expansion - Following its listing on the ChiNext board in 2023, Haofan Bio has accelerated its R&D and production capacity upgrades, including the construction of a new R&D building and the introduction of advanced equipment, increasing its R&D personnel by 30% [3][6]. - The company is also expanding its production bases to alleviate capacity constraints, with plans to establish 3 to 5 workshops at its Huai'an production base by next year [6]. Acquisition Strategy - A key part of Haofan Bio's strategy to address capacity issues includes the planned acquisition of Hangzhou Foster Pharmaceutical for 160 million yuan, which will provide additional production capacity and facilitate the transition of new products from small-scale to larger-scale production [6][7]. Future Outlook - The global peptide drug market is expected to exceed 100 billion USD by 2027, presenting significant growth opportunities for Haofan Bio, although the company acknowledges the challenges posed by rapid changes in pharmaceutical demand [6][7]. - The company emphasizes a cautious approach to future expansions, preferring to focus on solidifying its core product quality and maintaining a stable market position rather than pursuing aggressive acquisitions [6][7].

Group 1 - The core viewpoint of the news is that Haofan Bio experienced a decline in stock price and trading volume, with significant financing and margin trading activities indicating high investor interest and potential volatility [1][2][3] Group 2 - As of September 23, Haofan Bio's stock price fell by 2.15%, with a trading volume of 120 million yuan. The net financing buy was -3.15 million yuan, indicating more selling than buying on that day [1] - The financing balance for Haofan Bio reached 144 million yuan, accounting for 5.21% of its market capitalization, which is above the 80th percentile of the past year, suggesting a high level of leverage [1] - On the same day, Haofan Bio had a margin trading balance of 448,400 yuan, with a margin sell of 500 shares, indicating a relatively high level of short selling activity [1] Group 3 - As of June 30, Haofan Bio had 11,400 shareholders, an increase of 7.24% from the previous period, while the average number of circulating shares per shareholder decreased by 6.75% [2] - For the first half of 2025, Haofan Bio reported a revenue of 270 million yuan, representing a year-on-year growth of 20.10%, and a net profit of 75.88 million yuan, up 15.31% year-on-year [2] Group 4 - Since its A-share listing, Haofan Bio has distributed a total of 95.54 million yuan in dividends [3] - As of June 30, 2025, the sixth largest circulating shareholder of Haofan Bio is Huatai-PineBridge Healthcare Mixed Fund, holding 602,500 shares as a new shareholder, while two other funds exited the top ten list [3]

Group 1 - The core viewpoint of the news is that Haofan Bio has seen a significant increase in its stock price, rising by 5.33% to 57.15 CNY per share, with a total market capitalization of 6.172 billion CNY as of September 15 [1] - Haofan Bio, established on December 2, 2003, and listed on July 12, 2023, specializes in the research and sales of peptide synthesis reagents, protein crosslinkers, and molecular building blocks [1] - The revenue composition of Haofan Bio's main business includes peptide synthesis reagents at 81.89%, general molecular building blocks at 10.99%, protein reagents at 6.11%, and other products at 1.01% [1] Group 2 - Among the top circulating shareholders of Haofan Bio, a fund under Huatai PineBridge has entered the top ten, with the Huatai Medical and Health Mixed Fund (470006) holding 602,500 shares, representing 1.5% of the circulating shares [2] - The Huatai Medical and Health Mixed Fund (470006) was established on September 21, 2010, with a latest scale of 2.358 billion CNY, achieving a year-to-date return of 38.91% and a one-year return of 46.74% [2] - The fund manager of Huatai Medical and Health Mixed Fund is Zheng Lei, who has a tenure of 10 years and 276 days, with the fund's total asset scale at 7.072 billion CNY [3]

Core Viewpoint - Haofan Bio experienced a 5.23% increase in stock price, reaching 58.20 CNY per share, with a trading volume of 116 million CNY and a turnover rate of 4.82%, resulting in a total market capitalization of 6.286 billion CNY [1] Company Overview - Suzhou Haofan Bio Co., Ltd. is located at Changting Road 1, Suzhou High-tech Zone, Jiangsu Province, and was established on December 2, 2003. The company went public on July 12, 2023. Its main business involves the research and sales of peptide synthesis reagents, protein crosslinkers, and molecular building blocks [1] Shareholder Information - Among the top ten circulating shareholders of Haofan Bio, a fund under Huatai PineBridge holds a position. The Huatai Medical and Health Mixed Fund (470006) entered the top ten circulating shareholders in the second quarter, holding 602,500 shares, which accounts for 1.5% of the circulating shares. It is estimated that the fund has earned approximately 1.7411 million CNY in floating profit today [2] - The Huatai Medical and Health Mixed Fund (470006) was established on September 21, 2010, with a latest scale of 2.358 billion CNY. Year-to-date returns stand at 35.59%, ranking 1703 out of 8254 in its category; the one-year return is 41.87%, ranking 3403 out of 8037; and since inception, the return is 171.31% [2] - The fund manager of Huatai Medical and Health Mixed Fund (470006) is Zheng Lei, who has a cumulative tenure of 10 years and 262 days. The total asset scale under his management is 7.072 billion CNY, with the best fund return during his tenure being 53.42% and the worst being -21.99% [2]

Core Insights - Suzhou has successfully listed 7 companies in July, matching the total number of new listings in the first half of the year, positioning the city among the top in the nation [1][2] - The total number of listed companies in Suzhou has reached 254, with 210 on A-shares, ranking fifth nationally, and 51 on the Sci-Tech Innovation Board, ranking third among cities [1][2] - The city aims to exceed 300 listed companies by 2025, with a target of over 100 new technology listings and the creation of more than five companies with a market value of over 100 billion [2][4] Company Listings - Notable companies listed in July include Langwei Electronics, Haofan Bio, Yinghuate, and Guangge Technology, contributing to the surge in new listings [2][3] - Haofan Bio, a leader in peptide synthesis reagents, raised 1.827 billion yuan in its IPO, while Guangge Technology focuses on fiber optic sensing networks [2][3] - Yinghuate has become the largest domestic manufacturer of refrigeration scroll compressors, breaking foreign monopolies, and expanding its product range post-listing [3] Financial Ecosystem - The growth of listed companies is supported by a robust financial ecosystem, with policies aimed at integrating finance with innovation and supporting industrial clusters [4][5] - Suzhou has established a comprehensive financial service system to facilitate direct financing and attract capital, including the launch of a 100 billion yuan fund cluster [5][6] - Recent initiatives include the establishment of service bases for major national capital market platforms to enhance support for innovative enterprises [6]