Core Viewpoint - The article discusses the innovative strategies employed by Baiaosaitu in antibody drug development, focusing on their dual-core platform of a human antibody library and a humanized mouse model library, which addresses key challenges in the industry and enhances drug development efficiency [6][12][33]. Group 1: Antibody Drug Development Challenges - The majority of failures in antibody drug development stem from mismatches between candidate antibody molecules and the complex human environment, as well as between preclinical animal models and actual disease mechanisms [5]. - Successful antibody drug development requires high-quality antibody molecules and humanized mouse models that accurately simulate human pathophysiological processes [6][10]. Group 2: Baiaosaitu's Innovative Approaches - Baiaosaitu's "Thousand Mice and Ten Thousand Antibodies" initiative aims to create a comprehensive human antibody sequence library, significantly improving the drug discovery process [8][10]. - The company has developed over 1,000 gene-edited models, including more than 1,700 humanized mouse models, establishing a leading position in the global market [16][18]. Group 3: Financial Performance and Growth - Baiaosaitu's revenue has shown a compound annual growth rate of 40.2% since 2020, with projected revenue of 980 million in 2024, reflecting strong growth [23][27]. - The company achieved profitability for the first time in 2024, with a net profit of 114 million in the first three quarters of 2025, indicating improved financial health [27][30]. Group 4: Market Position and Collaborations - Baiaosaitu has established partnerships with over 950 global clients, including all top ten pharmaceutical companies, highlighting its strong market presence [16][18]. - The company’s humanized mouse model library supports various disease areas, making it a crucial partner for pharmaceutical companies in preclinical evaluations [16][19].

1.4980D ，a。 科创板投资风险提示：本次股票发行后拟在科创板市场上市，该市场具有较高的投 资风险。科创板公司具有研发投入大、经营风险高、业绩不稳定、退市风险高等特 点，投资者面临较大的市场风险。投资者应充分了解科创板市场的投资风险及本公 司所披露的风险因素，审慎作出投资决定。 百奥赛图（北京）医药科技股份有限公司 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. （北京市大兴区中关村科技园区大兴生物医药产业基地宝参南街 12 号院） 首次公开发行股票并在科创板上市 招股说明书 保荐人（主承销商） 百奥赛图（北京）医药科技股份有限公司 招股说明书 声明 中国证监会、交易所对本次发行所作的任何决定或意见，均不表明其对注册申请文 件及所披露信息的真实性、准确性、完整性作出保证，也不表明其对发行人的盈利能力、 投资价值或者对投资者的收益作出实质性判断或保证。任何与之相反的声明均属虚假不 实陈述。 根据《证券法》的规定，股票依法发行后，发行人经营与收益的变化，由发行人自 行负责；投资者自主判断发行人的投资价值，自主作出投资决策，自行承担股票依法发 行后因发行人经营与收 ...

1.4980D ，a。 科创板投资风险提示：本次股票发行后拟在科创板市场上市，该市场具有较高的投 资风险。科创板公司具有研发投入大、经营风险高、业绩不稳定、退市风险高等特 点，投资者面临较大的市场风险。投资者应充分了解科创板市场的投资风险及本公 司所披露的风险因素，审慎作出投资决定。 百奥赛图（北京）医药科技股份有限公司 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. （北京市大兴区中关村科技园区大兴生物医药产业基地宝参南街 12 号院） 首次公开发行股票并在科创板上市 招股意向书 保荐人（主承销商） 北京市朝阳区建国门外大街 1 号国贸大厦 2 座 27 层及 28 层 一、发行人上市的目的 发行人是一家创新药临床前 CRO 及生物技术公司，自成立以来，发行人始终以创 新为公司之本，坚持不懈推进公司基因编辑技术、抗体发现平台、创新动物模型以及药 理药效评价等研发活动，研发投入水平相对较高。通过本次首次公开发行股票并上市， 发行人能够通过搭配使用债权融资以及股权融资工具，优化财务结构，降低财务风险， 为公司未来创造更加稳健的经营环境，提升公司经营业绩，从而进一步提 ...

Core Viewpoint - The company, BaiOsaite (688796.SH), has announced its initial public offering (IPO) on the Sci-Tech Innovation Board, planning to issue 47.5 million shares, which represents 10.63% of the total share capital post-issue [1] Group 1: Company Overview - Established in 2009, the company operates as a preclinical Contract Research Organization (CRO) and biotechnology firm, focusing on gene editing technology to provide innovative model animals and preclinical drug development services [1] - The company has developed the RenMice platform, which includes various series of fully human antibodies/TCR mice, aimed at large-scale drug discovery targeting over a thousand potential drug targets [1] - The company has evolved into a comprehensive entity with four technical platforms: gene-edited model animal preparation, innovative model animal breeding and supply, preclinical pharmacology and efficacy evaluation, and antibody drug discovery [1] Group 2: Business Performance - As of the reporting period, the company has completed approximately 5,300 customized gene editing projects and developed over 4,300 types of gene-edited animals and cell line models [2] - The company’s innovative model animals and cell products include humanized mouse models targeting immune checkpoints and cytokines, severe immunodeficient mice, various spontaneous disease models, and human-derived cell lines, covering areas such as tumors, autoimmune diseases, metabolism, and neurology [2] - The company's main business revenues for the reporting periods were 533 million yuan, 716 million yuan, 980 million yuan, and 621 million yuan, with a compound annual growth rate of 35.56% from 2022 to 2024 [2] Group 3: Fundraising and Investment Plans - The funds raised from the IPO, after deducting issuance costs, will be allocated to several projects in order of priority: early drug development service platform construction, antibody drug research and evaluation, preclinical research projects, and supplementing working capital, with a total investment amount of 1.185 billion yuan [3]