Core Viewpoint - The article discusses the safety of antihistamines and nasal steroids used for allergy treatment, clarifying that they do not cause addiction and emphasizing the importance of consistent medication use to prevent worsening allergy symptoms [1][3]. Group 1: Antihistamines and Nasal Steroids - The main types of antihistamines available in the market are second-generation antihistamines, such as cetirizine and loratadine, which do not affect the central nervous system [3]. - Nasal steroids, commonly used for allergies, act locally and do not enter systemic circulation, further ensuring their safety [3]. Group 2: Side Effects and Precautions - Some antihistamines may cause drowsiness and impaired concentration, which poses risks for individuals engaged in high-concentration tasks such as operating machinery or driving [5].

Core Viewpoint - Chronic sinusitis with nasal polyps is a prevalent condition in China, affecting approximately 100 million people, with 20 to 30 million patients experiencing nasal polyps, which significantly impacts their quality of life [1][2]. Group 1: Disease Prevalence and Symptoms - The prevalence of chronic sinusitis in China is estimated to be around 8%, translating to about 100 million patients [1]. - Common symptoms include nasal congestion, purulent nasal discharge, olfactory/taste reduction, and facial pain, which can severely affect patients' quality of life [1][2]. Group 2: Treatment Approaches - The primary treatment strategy combines corticosteroid medication and surgical intervention, but the management of chronic sinusitis with nasal polyps is challenging due to high recurrence rates [1][3]. - Surgical removal of nasal polyps aims to restore normal airflow and drainage, but it does not guarantee a permanent solution, necessitating ongoing medication and follow-up care [3][4]. Group 3: Advances in Treatment - The emergence of biologic therapies represents a significant advancement in treatment, allowing for more precise and effective management of the disease by targeting the underlying inflammatory mechanisms [4][5]. - Biologic agents focus on key inflammatory pathways associated with type 2 inflammation, which is relevant for patients with chronic sinusitis, nasal polyps, asthma, and other comorbidities [5].