Financial Data and Key Metrics Changes - In Q4 2025, total revenue was approximately $12.5 billion, flat year-over-year, while the growth portfolio revenue increased by 15% to $7.4 billion, representing nearly 60% of total revenue [14][15] - For the full year, the growth portfolio grew 17%, offsetting a decline of roughly $4 billion in revenue from the legacy portfolio [6][7] - Adjusted diluted earnings per share for Q4 were $1.26, and for the full year, it was $6.15, both including a net charge related to in-process R&D and licensing income [20] Business Line Data and Key Metrics Changes - Opdivo revenue grew 7% to nearly $2.7 billion in Q4, driven by new indications and share growth in first-line non-small cell lung cancer [15] - Reblozyl achieved 21% growth, reflecting solid uptake across MDS-associated anemia patients [16] - Breyanzi's revenue increased by 47% in Q4, driven by strong demand across its approved indications [16] - Eliquis revenue was nearly $3.5 billion in Q4, up 6%, supported by demand growth and market share gains [16] Market Data and Key Metrics Changes - The U.S. market for Eliquis saw a 4% revenue increase, contributing to its overall growth [16] - Camzyos revenue grew 57% to $353 million in Q4, benefiting from global demand growth [17] - Sotyktu's global revenue grew 3%, with upcoming PDUFA dates for psoriatic arthritis and phase III readouts for lupus and Sjögren's disease [17] Company Strategy and Development Direction - The company aims to deliver industry-leading sustainable growth into the 2030s, focusing on executing its growth strategy and advancing its pipeline [11][23] - A multi-year plan is in place to rewire the company for long-term growth, with expectations to introduce over 10 new medicines and 30 meaningful launch opportunities by 2030 [9][10] - The company is expanding the use of AI to enhance operational efficiency and reinvest strategically in growth [11] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the growth portfolio's ability to drive revenue despite anticipated declines in the legacy portfolio due to ongoing LOE impacts [12] - The company expects 2026 revenue in the range of $46-$47.5 billion, with a projected decline of 12%-16% in the legacy portfolio [12][21] - Management highlighted the importance of maintaining a strong say-to-do ratio and delivering on commitments as part of the company culture [11] Other Important Information - The company completed a targeted $10 billion debt paydown ahead of schedule and generated strong cash flow from operations of approximately $2 billion in Q4 [20] - The effective tax rate for Q4 was 22.1%, reflecting a one-time non-tax deductible in-process R&D charge related to the Orbital acquisition [19] Q&A Session Summary Question: Insights on pivotal catalysts for 2026 - Management highlighted the potential for over 10 phase III data readouts this year, with a focus on products like Milvexian and Admilparant [25][28] Question: Eliquis dynamics for 2026 - Eliquis is expected to grow 10%-15% in 2026, driven by market share gains and pricing strategy adjustments [39] Question: Business development priorities - The company is focused on deepening its presence in existing therapeutic areas while remaining opportunistic for new opportunities [37] Question: Milvexian AFib study updates - The study is progressing well, with a focus on demonstrating non-inferiority to Eliquis and potential benefits in bleeding risks [46] Question: Admilparant's hypotension risk - Management indicated that the hypotension risk is being well managed in the phase three studies, with a focus on higher dosing [89]

Summary of Bristol-Myers Squibb Company (NYSE:BMY) FY Conference Call Company Overview - **Company**: Bristol-Myers Squibb Company (BMY) - **Event**: 44th Annual JPMorgan Healthcare Conference - **Date**: January 12, 2026 Core Industry Insights - **Focus**: The company aims to build a financially strong organization capable of delivering sustainable growth into the 2030s and beyond [2][16] - **Growth Portfolio**: Increased by 17% in the first nine months of 2025, with four products each generating over $1 billion in annual sales [3][2] - **Key Products**: - Opdualag (melanoma) - Breyanzi (CAR-T therapy for lymphoma) - Camzyos (treatment for obstructive HCM) - Reblozyl (annualizing over $2 billion in sales) [3][2] Financial Performance - **Debt Management**: Achieved a $10 billion debt paydown ahead of schedule, resulting in a stronger balance sheet [5][4] - **Cost Optimization**: On track to deliver $2 billion in cost savings, enhancing financial discipline [4][18] - **Shareholder Returns**: Returned over $22 billion to shareholders in the last three years and increased dividends for 17 consecutive years [15][16] Pipeline and R&D Developments - **Pipeline Progress**: Significant advancements in the pipeline with multiple late-stage assets expected to deliver value [5][11] - **Key Late-Stage Assets**: - **Cobenfy**: Approved for schizophrenia; pivotal studies in Alzheimer's disease psychosis expected to read out this year [6][11] - **Milvexian**: A Factor XIa inhibitor with potential in atrial fibrillation and secondary stroke prevention; phase III results anticipated [6][11] - **Admilparant**: Targeting pulmonary fibrosis with phase III results expected [7][11] - **Iberdomide and Mezigdomide**: Oral CELMoDs in multiple myeloma, with promising data leading into phase III trials [9][11] Strategic Focus Areas - **Business Development**: Completed $30 billion in deals over the past 24 months, with a focus on enhancing the growth profile [16][26] - **Execution and R&D**: Emphasis on improving execution across the organization, leveraging AI and machine learning to enhance R&D efficiency [13][30] - **Therapeutic Areas**: Continued focus on building depth in core therapeutic areas while exploring opportunities in adjacent markets [27][28] Market Position and Competitive Landscape - **Confidence in Product Portfolio**: Strong confidence in the existing product portfolio, with Eliquis continuing to perform well despite patent expirations [21][22] - **Diversified Pipeline**: The company has a diversified set of assets, reducing reliance on any single product for growth [23][24] - **Regulatory Engagement**: Positive engagement with the administration regarding Medicaid and pricing strategies, aiming to simplify the healthcare ecosystem [49][50] Conclusion - **Outlook for 2026**: The company is positioned for a busy year with multiple data readouts and product launches expected, focusing on commercial execution and maintaining financial discipline [47][48] - **Long-Term Vision**: Aiming for sustained growth through a diversified portfolio and strategic investments in R&D and business development [12][16]