神经系统 整合了 免疫 、 内分泌 和 循环系统 ，以协调复杂的生理反应。它通过与癌细胞和免疫细胞的相 互作用以及调控 肿瘤微环境 （TME） 和 肿瘤宏环境 （TMaE） 内的代谢过程，影响肿瘤的进展和治疗抵 抗。 2026 年 2 月 27 日， 复旦大学附属中山医院 樊嘉 院士、 季彤 教授、 孙云帆 教授等 （ 张誉 、 庄伟杰 、 朱浩东 为第一作者 ） ，在 Cell 子刊 Cell Metabolism 上 发表了题为： Neuroimmunometabolic co- evolution in the tumor micro- and macroenvironment 的综述论文。 该综述全面概述了 肿瘤微环境 （TME） 和 肿瘤宏环境 （TMaE） 内的神经免疫代谢的协同进化。在 TME 尺度上，讨论了外周神经系统 （PNS） ，包括交感神经、副交感神经和感觉神经元，在调控代谢过 程和免疫细胞功能方面的作用。在 TMaE 尺度上，强调了癌细胞如何利用脑-体相互作用来重编程全身代 谢和免疫反应，从而创造有利于肿瘤进展的条件。此外，该综述还描述了 PNS 如何作为肿瘤与远端器官之 间长距离通信 ...

Core Insights - The article emphasizes the risks associated with overusing pain relief medications for migraine sufferers, potentially leading to medication overuse headache (MOH) [1][2][3] - It highlights the importance of timely treatment for migraines and the dangers of both under-treatment and over-treatment [2][3] Group 1: Migraine and Its Implications - Migraine is characterized by recurrent, often unilateral, moderate to severe pulsating headaches, accompanied by symptoms such as nausea and sensitivity to light and sound [2] - The condition can lead to various comorbidities, including sleep disorders, anxiety, and depression, and significantly increases the risk of cardiovascular diseases, with studies showing a 1.73 times higher risk of stroke [2][3] Group 2: Medication Overuse Headache (MOH) - MOH occurs when patients experience worsening headaches due to excessive use of acute pain relief medications, which can lead to a vicious cycle of increased headache frequency and severity [2][3] - A clear warning sign for potential MOH is using non-steroidal anti-inflammatory drugs (NSAIDs) more than 15 days a month or triptans over 10 days a month [2][3] Group 3: Healthcare Initiatives and Solutions - In China, approximately 130 million migraine patients exist, with only 52.9% seeking medical attention, indicating a significant gap in treatment [4] - The establishment of headache centers and a national headache prevention network aims to improve diagnosis and treatment, with 740 centers already set up across 30 provinces [4] - The "MOH Zero Project" initiated by the Chinese People's Liberation Army General Hospital aims to reduce the risk of MOH through a comprehensive approach to screening, diagnosis, and treatment [4][5]